Imidazolesulfonamide derivatives and herbicides

ABSTRACT

There is disclosed imidazolesulfonamide derivatives represented by the general formula (I): ##STR1## wherein Q, m, R, B, D and T represent a group as specified in the specification and 
     herbicides containing the same as an active ingredient.

BACKGROUND OF THE INVENTION

This invention relates to a novel imidazolesulfonamide derivative, aprocess for preparing the compound and a herbicide containing thecompound as an active ingredient.

In order to protect important crops such as rice plants, wheat, corn,soybean, cotton, beat, etc. from damages by weeds to achieve anincreased yield, it is indispensable to use a herbicide. In recent yearsin particular, a herbicide having selectivity (or discriminativity) issought after as it can kill only weeds selectively without damages tocrops even when a foliage treatment with the herbicide is appliedsimultaneously on crops and weeds in a cultivated land wherein usefulcrops and weeds are grown together. Also, from viewpoints of preventionof environmental pollution, the transportation, and the economical costreduction in application of chemicals, studies and researches have beenmade over many years on such compounds that may achieve a higherherbicidal activity with use of chemicals in a lower amount. Some of thecompounds having such a property are presently used as the herbicidehaving selectivity. Still, however, there are further demands for newcompounds having such a property.

SUMMARY OF THE INVENTION

The present inventors have made researches over many years to developherbicides having the selectivity on important crops, and have examinedherbicidal properties of a number of compounds to create compoundshaving a higher herbicidal effect and the selectivity. As a result, itwas found that an imidazolesulfonamide derivative represented by generalFormula (I) (hereinafter referred to as "the compound of thisinvention): ##STR2## wherein Q represents a group of; ##STR3## whereinR¹, R² and R³ each independently represent a hydrogen atom, a halogenatom, a nitro group, a lower alkyl group, a halogenated lower alkylgroup, a cyano group, a group of COOR¹⁰, a group of S(O)_(n) R¹¹, agroup of NR¹² R¹³, a lower alkoxy group, a group of SO₂ NR⁸ R⁹, a groupof SO₂ OR¹¹ or a phenyl group which may be substituted (the substituentis selected from a halogen atom, a nitro group, a group of COOR¹⁰, alower alkoxy group and a lower alkyl group);

R⁴ and R⁵ each independently represent a hydrogen atom, a halogen atom,a lower alkyl group, a halogenated loweralkyl group, a nitro group, acyano group, a group of COOR¹⁰, a group of S(O)_(n) R¹¹, a lower alkoxygroup or a phenyl group which may be substituted (the substituent isselected from a halogen atom, a group of COOR¹⁰, a nitro group, a loweralkoxy group and a lower alkyl group);

R⁶ and R⁷ each independently represent a hydrogen atom, a halogen atom,a lower alkyl group, a lower alkoxy group, a nitro group or a group ofCOOR¹⁰ ;

R⁸ and R⁹ each independently represent a hydrogen atom, a lower alkylgroup or a phenyl group;

W¹ represents an oxygen atom, a sulfur atom or a group of N--R¹⁰ ;

R¹⁰ represents a hydrogen atom or a lower alkyl group;

R¹¹ represents a lower alkyl group and n represents an integer of 0, 1or 2; and

R¹² and R¹³ each independently represent a hydrogen atom or a loweralkyl group,

m represents an integer of 0, 1 or 2;

R repesents a hydrogen atom or a lower alkyl group;

B and D each independently represent a hydrogen atom, a halogen atom, anitro group, a lower alkyl group, an aralkyl group, a lower alkoxygroup, a halogenated alkyl group, a halogenated alkenyl group, a loweralkoxyalkyl group, an alkylcarbonyl group, a group of COOR¹⁴, a group ofCONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group of NR¹⁸ R¹⁹,a group of SO₂ NR²⁰ R²¹ , a hydroxy group, a benzoyl group which may besubstituted (the substituent is selected from a halogen atom and a loweralkyl group) or a phenyl group which may substituted (the substituent isselected from a halogen atom, a nitro group, a group of COOR¹⁰, a loweralkoxy group and a lower alkyl group);

R¹⁴ represents a hydrogen atom, a lower alkyl group which may besubstituted (the substituent is selected from a lower alkoxy group whichmay be substituted by a group of OR¹⁰, a halogen atom, a halogenatedlower alkoxy group, a cyano group, a phenoxy group, a loweralkoxycarbonyl group, a group of NR¹⁰ R¹¹, a lower cycloalkyl group, alower alkylthio group and a lower alkylcarbonyl group), a lower alkenylgroup, a halogenated lower alkenyl group, a lower alkynyl group, ahalogenated lower alkynyl group, a halogenated lower cycloalkyl group ora benzyl group;

R¹⁵ represents a hydrogen atom, a lower alkyl group or a phenyl group;and R¹⁶ represents a hydrogen atom, a lower alkyl group or a loweralkoxy group;

R¹⁷ represents a lower alkyl group, a lower alkoxy group, a phenylgroup, a halogenated alkyl group, a lower alkenyloxy group or a loweralkynyloxy group; and n represents an integer of 0, 1 or 2;

R¹⁸ and R¹⁹ each independently represent a hydrogen atom, a lower alkylgroup, a lower alkylcarbonyl group or a lower alkylsulfonyl group;

R²⁰ and R²¹ each independently represent a hydrogen atom, a lower alkylgroup, a lower alkenyl group or a lower alkynyl group;

T represents a group of ##STR4## E represents a hydrogen atom, a loweralkyl group, a lower alkenyl group, a lower alkynyl group or a loweralkoxy group;

G represents a group of; ##STR5## wherein X and Y each independentlyrepresent a hydrogen atom, a halogen atom, a lower alkyl group, a loweralkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, ahalogenated lower alkoxy group, a group of NR²⁴ R²⁵, a group ofOCH(R¹⁰)COOR¹⁰, a group of COOR¹⁰, a cyclopropyl group, a group ofCH(OR²⁶)₂, a lower alkylthio group or a halogenated lower alkylthiogroup,

R²⁴ and R²⁵ each independently represents a hydrogen atom, a lower alkylgroup or a lower alkoxy group;

R²⁶ represents a lower alkyl group;

X¹ and Y¹ each independently represent a hydrogen atom, a halogen atom,a lower alkyl group, a halogenated alkyl group or a lower alkoxy group;

X² represents a lower alkyl group, a lower alkylthio group or a loweralkoxy group, and Y² represents a lower alkyl group;

Z represents a nitrogen atom or a group of C--R²⁷,

R²⁷ represents a hydrogen atom, a lower alkyl group, a halogenated loweralkyl group, a halogen atom, a lower alkoxy group or a 5-membered ringstructure containing an oxygen atom together with Y or Y¹ ;

X³ represents a lower alkyl group, a lower alkoxy group, a loweralkoxyalkyl group or a halogen atom;

Y³ represents a lower alkyl group, a lower alkoxy group, a halogen atom,a monoalkylamino group or a dialkylamino group;

Y⁴ represents a cyano group, a group of CO₂ R¹⁰, a nitro group, a groupof S(O)_(n) R¹¹, an alkyl group or a halogenated alkyl group;

Z¹ represents a nitrogen atom or a group of CH;

X⁴ and Y⁵ each independently represent a lower alkyl group or a loweralkoxy group;

W represents an oxygen atom, a sulfur atom or a group of N--R²⁸ (whereinR²⁸ represents a hydrogen atom or a lower alkoxy group);

W² represents an oxygen atom or a sulfur atom;

R²² represents a lower alkyl group;

Az represents a halogen atom, a nitro group, or an imidazolyl group, animidazolynyl group, a pyrazolyl group, a triazolyl group or abenzimidazolyl group each of which may be mono-, di- or tri-substitutedby a lower alkyl group;

J represents a lower alkyl group or a group of ##STR6## wherein Q, R, m,B and D have the same meanings as defined above; and R²³ represents ahydrogen atom, a lower alkyl group or a lower alkoxy group,

has a strong herbicidal effect to various weeds while retaining highsafety to the important crops in either case of the soil treatment orthe foliage treatment, whereby this invention has been accomplished. Thecompound of this invention shows a high herbicidal activity in anapplication of a very low amount of the active ingredient as comparedwith the conventional herbicides, and accordingly it is useful also as aherbicide for orchards and uncultivated lands.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

As a prior technique, for example, Japanese Provisional PatentPublication No. 162587/1983 and No. 1480/1984 discloseimidazolesulfonylurea which has the structure similar to the compound ofthis invention. However, there has been disclosed no compound wherein aheterocyclic ring is substituted on an imidazole ring as the compound ofthis invention. Thus, the compound of this invention can be said to be anovel one.

In the present invention, preferred componds represented by the formula(I) are as follows: ##STR7## wherein R₁ represents a hydrogen atom, amethyl group, a halogen atom or a nitro group; R represents a methylgroup or an ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9,Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138Q142, Q188,Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 andQ250 as mentioned on pages 45 to 57 hereinbelow;

X and Y are each independently a halogen atom, a methyl group, a methoxygroup; and Z is --CH═ or --N═.

The compound of this invention, represented by general formula (I) canbe readily prepared by selecting any of reaction schemes 1 to 7 shownbelow. ##STR8## wherein B, D, E, G, Q, R, W² and m have the samemeanings as defined above.

More specifically, the imidazolesulfonyl(thio)isocyanate derivative (II)is dissolved in a sufficiently dried inert solvent such as dioxane andacetonitrile and thereto is added a pyrimidine, triazine or triazolederivative represented by Formula (III), with stirring. Thus, thereactants generally are reacted with each other rapidly to give thecompound (I)' which is part of the compound of this invention. In caseswhere it is difficult for the reaction to proceed, a trace or smallamount of suitable base, such as triethylamine, triethylenediamine,pyridine, a sodium alkoxide, sodium hydride and the like, may be addedto the reaction system to allow the reaction to proceed readily.##STR9## wherein B, D, E, G, Q, R, W² and m have the same meanings asdefined above. R²⁹ represents a lower alkyl group or a phenyl group.

More specifically, the imidazolesulfonamide derivative (V) is reactedwith a chloroformic acid (thio)ester or a carbonic acid (thio)ester in asolvent such as acetone, methyl ethyl ketone and acetonitrile in thepresence of a base such as potassium carbonate to give the compound(IV). Subsequently, the resulting (IV) is heated with the compound (III)in a solvent such as tolune to give the compound (I)' which is a part ofthe compound of this invention. ##STR10## wherein B, D, E, G, Q, R, W²and m have the same meanings as defined above. R²⁹ represents a loweralkyl group or a phenyl group.

More specifically, by reacting the imidazolesulfonamide derivative (V)with an N-heterocylic carbamate (III)' in the presence of an inorganicsalts such as hydroxides, hydrides, etc., or an organic bases such asalkylamine, pyridine, 1,8-diazabicyclo(5.4.0)-7-undecene in an inertsolvent such as methylene chloride, tetrahydrofuran, acetonitrile, etc.,the compound (I)' which is a part of the compound of this invention canbe obtained. ##STR11## wherein B, D, E, G, Q, R, m, R²² and R²³ have thesame meanings as defined above. ##STR12## wherein Az, B, D, E, G, Q, R,W², m, R²² and R²³ have the same meanings as defined above. ##STR13##wherein Az, B, D, E, G, Q, R and m have the same meanings as definedabove.

More specifically, the above imidazolesulfonamide derivative in any ofReaction schemes 4 to 6, which is a part of the compound of thisinvention can be synthesized in accordance with the process disclosed inJapanese Provisional Patent Publications No. 167570/1984, No. 6654/1985,No. 36467/1985, No. 60670/1986, No. 60684/1986 and No. 72783/1986.##STR14## wherein B, D, E, G, Q, R, W and m have the same meanings asdefined above; and Hal represents a halogen atom.

More specifically, 1H-imidazolesulfonylurea is reacted with aHal--(CHR)_(m) --Q in the presence of an appropriate base to give thecompound (I)' which is a part of the compound of this invention. Benoted that in case where m is 0, Q desirably has an electron attractivegroup such as a nitro group, CF₃, a halogen atom or the like as asubstituent therefor in many occasions and the Hal-group is required tohave high reactivity.

The starting material, the imidazolesulfonyl(thio)isocyanate (II) or theimidazolesulfonyl(thio)carbamate derivative (IV) which is used inReaction schemes 1 and 2 may be synthesized by optionally selecting themethods as will be described hereinafter to synthesize theimidazolesulfonamide (V) and further converting the resulting product tothe desired product with reference to the methods as described inEuropean Patent Publication No. 87,780 (EP-A0 087 780) and JapaneseProvisional Patent Publication No. 13266/1980.

The imidazolesulfonamide which is an intermediate to be used in thepresent invention is also a novel compound, which can be obtained byoptionally selecting one of the following Reaction schemes 8 to 12 andthe methods described in Japanese Provisional Patent Publications No.162587/1983, No. 1480/1984, etc. ##STR15##

(a) NaNO₂.HCl or NaNO₂.HBr

(b) SO₂.Cu salt

(c) NH₄ OH or ammonium carbonate

(d) Cu salt

(e) NaSH

(f) NaOH.NH₄ OH/NaOCl

(g) Oxidizing agent

(h) NaSCH₂ Ph

(i) Cl₂ /CH₃ CO₂ H.H₂ O or NaOCl/HCl

(j)

(1) ClSO₃ H

(2) SOCl₂ or PCl₅

(k)

(1) BuLi or LiN(i-Pr)₂

(2) SO₂

(3) N-chlorosuccinimide

(l) Q--(CHR)_(m) --Hal/base

In Reaction schemes 8 to 12, B, D, Q, R and m have the same meanings asdefined above; and Hal represents a halogen atom.

The imidazolesulfonamide (V) may usually be obtained by reacting acorresponding imidazolesulfonyl chloride with an aqueous ammonia orammonium carbonate. In order to introduce a sulfonyl group into animidazole ring, there may be adopted such methods as follows:

(1) The amino group is subjected to diazonium decomposition in thepresence of sulfur dioxide to give a imidazolesulfonyl chloride;

(2) A sulfur atom is introduced into the imidazole ring by anucleophilic substitution reaction with a halogen atom or the like andoptionally the resulting compound is further oxidized to given animidazolesulfonyl chloride;

(3) A carbanion of an imidazole is formed by using a base and sulfurdioxide is reacted therewith followed by halogenation to give animidazolesulfonyl chloride; and

(4) Chlorosulfonic acid or the like is used to directly give animdazolesulfonyl chloride in an electrophilic substitution reaction.

More specifically, (1) according to Reaction scheme 8, an aminoimidazoleis converted into a diazonium salt by using sodium nitrite or the likein hydrochloric acid, hydrobromic acid or the like and then sulfurdioxide is reacted with the resulting diazonium salt in the presence ofa catalyst which is usually used for diazonium decomposition such as acopper salt or the like, to afford a corresponding imidazolesulfonylchloride. With the resulting compound was reacted an aqueous ammonia togive the desired pyrazolesulfonamide (V).

(2) According to Reaction scheme 9, a halogenated imidazole is treatedwith sodium hydrosulfide, sodium salt of benzylmercaptan or the like tointroduce a sulfur atom into the imidazole ring, followed by oxidationwith chlorine in a solvent such as acetic acid/water to give animidazolesulfonyl chloride. As in Reaction scheme 8, a reaction with anaqueous ammonia gives the desired pyrazolesulfonamide (V). The desiredimidazolesulfonamide may also be obtained by converting the intermediateof mercaptopyrazole into a sulfenamide which is then oxidized. Thestarting material, the halogenated imidazole, may be obtained bydiazo-decomposition of an aminopyrazole; by the reaction of ahydroxyimidazole with phosphorus oxychloride or phosphorus oxybromide;or by formation of an anion by using a strong base such as butyllithium, lithium diisopropylamide or the like, followed by halogenation.

(3) According to Reaction scheme 11, an anion may be formed by using astrong base such as butyl lithium, lithium diisopropylamide or the like,and the resulting anion may further be treated with sulfur dioxide andsubsequently with an N-halogenosuccinimide to form an imidazolesulfonylchloride which is then treated with an aqueous ammonia to give thedesired imidazolesulfonamide (V).

(4) According to Reaction scheme 10, use of chlorosulfonic acid may givedirectly an imidazolesulfonyl chloride.

In addition to the above schemes, according to Reaction scheme 12, thedesired imidazolesufonamide (V) may be obtained by allowing animidazolesulfonamide having no substituent on the 1-position to reactwith an appropriate halogen derivative Hal--(CHR)_(m) --Q (wherein Q, R,m and Hal have the same meanings as defined above) in the presence of asuitable base. The reaction may be carried out in accordance withReaction scheme 7. In reactions in Reaction schemes 10 to 12, isomersmay possibly be formed in admixture with the desired compound dependingupon occasion. However, such isomers may be separated byrecrystallization, column chromatography or the like and used as anintermediate for the compound of this invention. General literatures forthe chemistry on the imidazoles used as starting materials in theabove-mentioned reactions include the following ones. M. R. Grimmett,Advanced Heterocyclic Chemistry, Vol. 12, p. 104 (1970); R. C.Elderfield, Heterocyclic Compounds, Vol. V, p. 194 (1957), published byJohn Wiley and Sons, Inc., New York; K. Schofield, M. R. Grimmett and B.R. T. Keene, Heteroaromatic Nitrogen Compounds The Azoles, published byCambridge University Press, (1976); M. R. Grimmett, ComprehensiveHeterocyclic Chemistry, Vol. 5, p. 345 (1984), published by PergamonPress.

The mercaptoimidazole derivative, for example, may be synthesized, asshown in Reaction scheme 13, according to methods described in R. G.Jones, E. C. Kornfeld, K. C. McLaughlin and R. C. Anderson, J. Am. Chem.Soc., Vol. 71, p. 4000 (1949). ##STR16## wherein Q, R, R¹¹ and m havethe same meanings as defined above; and B and D each independentlyrepresent a hydrogen atom or a lower alkyl group. ##STR17## wherein Q,R, R¹¹, W², m and Hal have the same meanings as defined above; Brepresents a hydrogen atom, a lower alkyl group or a lower alkylmercaptogroup; D represents an alkylcarbonyl group, a benzoyl group, a cyanogroup, an alkylsulfonyl group, a phenylsulfonyl group, a group of COOR¹⁴or a group of CONR¹⁵ R¹⁶ ; wherein R¹⁴, R¹⁵ and R¹⁶ have the samemeanings as defined above. ##STR18## wherein Q, R, R¹¹ and m have thesame meanings as defined above; B represents a hydrogen atom or a loweralkyl group; D represents a hydrogen atom, an alkylcarbonyl group, abenzoyl group, a cyano group, an alkylsulfonyl group, a phenylsulfonylgroup, a group of COOR¹⁴ or a group of CONR¹⁵ R¹⁶, in which R¹⁴, R¹⁵ andR¹⁶ have the same meanings as defined above.

An aminoimidazole may be synthesized, as shown in Reaction scheme 14,according to methods described in K. Gewald and G. Heinhold, Monatsh.Chem., Vol. 107, p. 1413 (1976), specification of East German Pat. No.118,640 and A. Edenhofer, Helv. Chim. Acta., Vol. 58, p. 2192 (1975) togive 4-aminoimidazole derivatives having various substituents. Also,5-aminoimidazole may be synthesized, as shown in Reaction scheme 15,according to methods described in D. H. Robinson and G. Shaw, J. Chem.Soc., Perkin Trans. I, p. 1715 (1972).

Further, a heterocyclic isothiocyanate which is a raw material to beused in a reaction of Reaction scheme 13 may be synthesized, for exampleas shown in Reaction scheme 16, according to methods desribed in D. J.LeCount, D. J. Dewsbury and W. Grundy, Synthesis, p. 582 (1977).##STR19## wherein Q, R and m have the same meanings as defined above.

Generally, a person skilled in the art would be able to obtain anintermediate for the compound of the present invention by investigatingexperimental conditions and the like taking into consideration the abovedescriptions and the prior art technologies as mentioned above.Hereinafter, there will be described Synthesis examples of the presentcompounds and the intermediate imidazolesulfonamide therefor by way ofExamples or Reference examples, which, however, should not be construedto limit the present invention.

REFERENCE EXAMPLE 1 Synthesis of 1-methyl-3-pyrazolylisothiocyanate

To a mixture of 29.1 g of 3-amino-1-methylpyrazole and 45 ml oftriethylamine was added dropwise 18 ml of carbon disulfide and theresulting mixture was stirred at 40° C. for 30 minutes to precipitatesolids. To the reaction mixture was added ether, followed bypulverization of solids. After filtration, the thus pulverized solidswere washed with ether to give 67 g of triethylamine salt of1-methyl-3-pyrazolyldithiocarbamic acid (melting point: 79° to 82° C.)31.8 g of the thus obtained triethylamine salt of dithiocarbamic acidand 11.7 g of triethylamine were dissolved in 150 ml of methylenechloride. To the resulting solution was added at one time 34.5 g offerric chloride 6 hydrate dissolved in 100 ml of water, followed byvigorous stirring for 10 minutes. The reaction mixture was filtered toremove insoluble solids. The organic layer was separated and then theaqueous layer was extracted with methylene chloride. After the organiclayers were combined, washed with water and dried, the solvent wasdistilled off under reduced pressure. To the thus obtained residue wasadded ether to filter the insoluble solids off and the filtrate wasconcentrated under reduced pressure to give 9.0 g of oil. The thusobtained oil was evaporated under reduced pressure to give 6.5 g of thedesired compound. b.p.: 135° to 138° C./23 mmHg.

REFERENCE EXAMPLE 2 Synthesis of1-(1-methylpyrazol-3-yl)imidazole-2-thiol

To 6.6 g of 2,2-diethoxyethylamine dissolved in 100 ml of ethanol wasadded 6.3 g of 1-methyl-3-pyrzolylisothiocyanate, followed by stirringat room temperature over night. Crystals precipitated were filtered outand washed with a small amount of ethanol to give 10.3 g ofN-2,2-diethoxyethyl-N'-(1-methylpyrazol-3-yl)thiourea (m.p.: 152° to155° C.). 10.0 g of the crystals thus obtained were suspended in 70 mlof water. To the resulting suspension was added 15 ml of conc.hydrochloric acid, followed by stirring under reflux with heating for 30minutes. The reaction mixture was cooled and adjusted to pH to 4 to 6with use of 50% aqueous sodium hydroxide solution to precipitatecrystals. The crystals precipitated were filtered out, washed with waterand dried to give 6.0 g of the desired compound. m.p.: 126° to 128° C.

REFERENCE EXAMPLE 3 Synthesis of1-(4-chloro-1-methylpyrazol-3-yl)imidazole- 2-sulfonamide

To a mixture of 5.8 g of 1-(1-methylpyrazol-3-yl)imidazole-2-thiol, 30ml of water, 60 ml of chloroform and 27 g of conc. hydrochloric acid wasadded dropwise 192 g of aqueous sodium hypochlorite solution (content of6%) under vigorous stirring at -10° to 0° C. over about 4 hours. Aftercompletion of the dropwise addition, the resulting mixture was stirredat the same temperature for 1 hour. Then, the organic layer wasseparated and the aqueous layer was extracted with chloroform. Theorganic layers were combined and washed with water. Then, to the organiclayer was added dropwise 20 ml of 28% aqueous ammonia under ice-cooling,followed by stirring at room temperature for 1.5 hours. Crystalsprecipitated by concentrating the resulting mixture under reducedpressure, were filtered out, washed with water and subsequently withether to give 2.9 g of the desired compound. m.p.: 208° to 210° C.

REFERENCE EXAMPLE 4 Synthesis of 1-methyl-5-pyrazolylisothiocyanate

Using 5-amino-1-methylpyrazole as a starting material, triethylaminesalt of 1-methyl-5-pyrazolyldithiocarbamic acid (m.p.: 89° to 94° C.)was synthesized, following the procedures described in ReferenceExample 1. Ferric chloride was allowed to act upon the resulting productto yield the desired compound. Oily substance.

REFERENCE EXAMPLE 5 Synthesis of1-(1-methylpyrazol-5-yl)imidazole-2-thiol

Using 1-methyl-5-pyrazolylisothiocyanate as a starting material, thedesired compound was obtained viaN-2,2-diethoxyethyl-N'-(1-methylpyrazol-5-yl)thiourea (m.p.: 148° to149° C.) as an intermediate, following the procedures described inReference Example 2. m.p.: 247° to 251° C.

REFERENCE EXAMPLE 6 Synthesis of1-(1-methylpyrazol-5-yl)imidazole-2-sulfonamide

To a mixture of 5.0 g of 1-(1-methylpyrazol-5-yl)imidazole-2-thiol, 30ml of water, 60 ml of chloroform and 23 g of conc. hydrochloric acid,was added dropwise 100 g of aqueous sodium hypochlorite (content of 6%)under vigorous stirring at -10° to 0° C. over 2.5 hours. Aftercompletion of the dropwise addition, the resulting mixture was stirredat the same temperature for 0.5 hour. Then the organic layer wasseparated and the aqueous layer was extracted with chloroform. After theorganic layers were combined and washed with water, to the organic layerwas added dropwise 20 ml of 28% aqueous ammonia under ice-cooling,followed by stirring at room temperature for 1.5 hours. Crystalsprecipitated by concentrating the resulting mixture under reducedpressure, were filtered out, washed with water and subsequently withether to give 3.4 g of the desired compound. m.p.: 230° to 233° C.

REFERENCE EXAMPLE 7 Synthesis of5-amino-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole

In 200 ml of acetonitrile, 6.7 g of ethyl-aminocyanoacetate, 8.5 g ofethyl orthoformate and 5.6 g of 3-amino-1-methylpyrazole were refluxedunder heating for 4.5 hours. After completion of the reaction, thesolvent was distilled off under reduced pressure. Crystals precipitatedwas filtered out, followed by washing with ether to give 7.5 g of thedesired compound. m.p.: 168° to 170° C.

REFERENCE EXAMPLE 8 Synthesis of5-chloro-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole

7.4 g of 5-amino-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole wasdissolved in 40 ml of conc. hydrochloric acid and the resulting solutionwas cooled to -5° C. Subsequently, 2.6 g of sodium nitrite was dissolvedin 10 ml of water and the resulting solution was added dropwise to thepreviously prepared solution while maintaining the temperature at -5° C.or lower. After completion of the dropwise addition, the resultingmixture was stirred at the same temperature for 0.5 hour. The thusobtained solution was added dropwise at around 5° C. to 120 ml of asolution of chloroform containing 0.5 g of cuprous chloride and 17 g ofsulfur dioxide. After the resulting mixture was stirred at roomtemperature for 1 hour, was added thereto 200 ml of water and theorganic layer was separated. The aqueous layer was extracted withchloroform and the organic layers were combined, washed with water anddried. The solvent was then removed by distillation to give 8.0 g of5-chloro-6-ethoxycarbonyl-1-(1-methylpyrazol- 3-yl)imidazole as an oil.

REFERENCE EXAMPLE 9 Synthesis of1-(4-chloro-1-methylpyrazol-3-yl)-4-ethoxycarbonylimidazole-5-sulfonamide

7.5 g of 5-chloro-4-ethoxycarbonyl-1-(1-methylpyrazol-3-yl)imidazole wasdissolved in 30 ml of dimethylformamide. To the resulting solution wasadded 5.9 g of sodium hydrosulfide (content of 70%), followed bystirring of the resulting mixture at 70° to 80° C. for 1.5 hours. Aftercompletion of the reaction, 100 ml of ice-cold water was added to thereaction mixture and the resulting mixture was made weakly acidic withuse of conc. hydrochloric acid. Subsequently, 100 ml of chloroform wasadded to the mixture and chlorine was introduced into the resultingmixture little by little at -10° to 0° C. over 2 hours. After completionof the reaction, the organic layer was separated and the aqueous layerwas extracted with chloroform. After the organic layers were combinedand washed with water, 20 ml of 28% aqueous ammonia was added dropwiseunder ice-cooling, followed by stirring of the resulting mixture at roomtemperature for 1.5 hours. Crystals precipitated by concentrating thereaction mixture under reduced pressure were filtered out and washedwith water and subsequently with ether to give 7.6 g of the desiredcompound. m.p.: 167° to 168° C.

REFERENCE EXAMPLE 10 Synthesis of5-amino-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole

Following the procedure described in Reference Example 7, the desiredcompound was synthesized using ethyl α-aminocyanoacetate, ethylorthoformate and 2-aminothiazole as raw materials. m.p.: 120° to 123° C.

REFERENCE EXAMPLE 11 Synthesis of5-chloro-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole

Following the procedure described in Reference Example 8, the desiredcompound was synthesized using5-amino-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole as a raw material.m.p.: 128° to 131° C.

REFERENCE EXAMPLE 12 Synthesis of4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole-5-thiol

8.0 g of 5-chloro-4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole wasdissolved in 30 ml of dimethylformamide. To the resulting solution wasadded 6.2 g of sodium hydrosulfide (content of 70%), followed bystirring of the resulting mixture at 60° C. for 1 hour. After completionof the reaction, the reaction mixture was poured into ice water and theresulting solution was made weakly acidic with conc. hydrochloric acid.Crystals precipitated were filtered out, washed and dried to give 7.5 gof the desired compound. m.p.: 155° to 158° C.

REFERENCE EXAMPLE 13 Synthesis of4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole-5-sulfonamide

The desired compound was synthesized following the procedures describedin Reference Example 6 by using4-ethoxycarbonyl-1-(thiazol-2-yl)imidazole-5-thiol as a raw material.m.p.: 84° to 85° C.

REFERENCE EXAMPLE 14 Synthesis of5-amino-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole

The desired compound was synthesized following the procedures describedin Reference Example 7 by using ethyl α-aminocyanoacetate, ethylorthoformate and 2-amino-4-methylthiazole as raw materials. m.p.: 152°to 155° C.

REFERENCE EXAMPLE 15 Synthesis of5-chloro-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole

The desired compound was synthesized following the procedures describedin Reference Example 8 by using5-amino-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as a rawmaterial. m.p.: 98° to 101° C.

REFERENCE EXAMPLE 16 Synthesis of4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole-5-thiol

The desired compound was synthesized following the procedures describedin Reference Example 12 by using5-chloro-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as a rawmaterial. m.p.: 193° to 195° C.

REFERENCE EXAMPLE 17 Synthesis of4-ethoxycarbonyl-1-(5-chloro-4-methylthiazol-2-yl)imidazole-5-sulfonamide

A mixture consisting of 4.2 g of4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole-5-thiol, 3.2 g ofanhydrous potassium carbonate, 2.2 g of benzyl chloride, 20 ml ofdimethylformamide and 100 ml of acetonitrile was stirred at roomtemperature for 2 hours. After the reaction, solid materials wereseparated by filtration, and the filtrate was condensed under reducedpressure to obtain crude5-benzylthio-4-ethoxycarbonyl-1-(4-methylthiazol-2-yl)imidazole as oilyproduct. The resulting oily product was dissolved in 100 ml ofchloroform and after addition of 13 g of conc. hydrochloric acid and 30ml of water, 28 g of a 10% sodium hypochlorite solution was addeddropwise to the mixture at -10° C. to -5° C. over 15 minutes. After thereaction mixture was stirred at 0° C. or lower for 20 minutes, anorganic layer was separated and an aqueous layer was extracted withchloroform. After the organic layers were combined and washed withwater, 60 ml of tetrahydrofuran was added to the organic layer and then20 ml of a 28% aqueous ammonia was added dropwise under icc-cooling, andthe mixture was stirred at room temperature for 1.5 hours. After thereaction mixture was concentrated under reduced pressure, ethyl acetateand water were added thereto, an organic layer was separated and anaqueous layer was extracted with ethyl acetate. The organic layers werecombined and dried, and then concentrated under reduced pressure toobtain oily product. The resulting oily product was identified as5-benzylsulfinyl-4-ethoxycarbonyl-1-(5-chloro-4-methylthiazol-2-yl)imidazoleby NMR and MS analyses.

The resulting oily product was again treated with sodium hypochlorite inaccordance with the above-mentioned method, and reacted with an aqueousammonia to obtain 0.86 g of the title compound. m.p.: 136° to 139° C.

REFERENCE EXAMPLE 18 Synthesis of5-amino-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole

The desired compound was synthesized following the procedures describedin Reference Example 7 by using ethyl α-aminocyanoacetate, ethylorthoformate and 2-amino-1,3,4-thiadiazole as raw materials. m.p.: 181°to 183° C.

REFERENCE EXAMPLE 19 Synthesis of5-chloro-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole

The desired compound was synthesized following the procedures describedin Reference Example 8 by using5-amino-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole as a rawmaterial. m.p.: 184° to 185° C.

REFERENCE EXAMPLE 20 Synthesis of4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-thiol

The desired compound was synthesized following the procedures describedin Reference Example 12 by using5-chloro-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole as a rawmaterial. m.p.: 182° to 185° C.

REFERENCE EXAMPLE 21 Synthesis of4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide

The desired compound was synthesized following the precedures describedin Reference Example 17 by using4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-thiol as a rawmaterial and via 5-benzylthio-4-ethoxycarbonyl-b1-(1,3,4-thiadiazol-2-yl)imidazole (m.p.: 113° to 115° C.) as anindermediate. m.p.: 168° to 171° C.

REFERENCE EXAMPLE 22 Synthesis of 1-(thiazol-2-yl)imidazole-2-thiol

To 200 ml of acetonitrile, 14.6 g ofN-(thiazol-2-yl)methyldithiocarbamate and 12 g of 2,2-diethoxyethylaminewere added and the mixture was refluxed under heating for 12 hours.After removing acetonitrile, diisopropyl ether was added to the residueand precipitated crystals were collected by filtration to obtain 9.5 gof N-2,2-diethoxyethyl-N'-(thiazol-2-yl)thiourea (m.p.: 118° to 119°C.). In 55 ml of water was suspended 8.5 g of the resulting crystals,and 25 ml of conc. hydrochloric acid was added thereto and then themixture was refluxed under heating for 5 hours. The reaction mixture wascooled and then the precipitated crystals were collected by filtration.The resulting crystals were dissolved in 30 ml of a 20% aqueous sodiumhydroxide solution and a pH thereof was adjusted to 7 to 6 toprecipitate crystals. The precipitated crystals were collected byfiltration, washed with water and then dried to obtain 5.0 g of thetitle compound. m.p.: 211° to 213° C.

REFERENCE EXAMPLE 23 Synthesis of1-(thiazol-2-yl)imidazole-2-sulfonamide

The desired compound was synthesized following the procedures describedin Reference Example 6 by using 1-(thiazol-2-yl)imidazole-2-thiol as araw material. m.p.: 157° to 162° C.

REFERENCE EXAMPLE 24 Synthesis of 1-(2-pyridyl)imidazole-2-sulfonamide

(1) Synthesis of 1-(2-pyridyl)imidazole-2-thiol

To a solution of 11.1 g of 2-pyridylisothiocyanate dissolved in 100 mlof ethanol, was added 10.0 g of aminoacetaldehyde diethylacetal,followed by stirring of the resulting mixture under reflux with heatingfor 40 minutes. After completion of the reaction, the solvent wasdistilled off under reduced pressure. Crystals precipitated werecollected by filtration to give 13.8 g ofN-2,2-diethoxyethyl-N'-(2-pyridyl)thiourea (m.p.: 132° to 133° C.). Tothe thus obtained crystals was added 120 ml of 10% diluted hydrochloricacid, followed by stirring of the resulting mixture under reflux withheating for 30 minutes. The reaction mixture was cooled and adjusted topH of 5 to 6 with use of 50% aqueous sodium hydroxide to precipitatecrystals. The crystals precipitated were filtered out, washed with waterand dried to give 8.3 g of the desired compound. m.p.: 162° to 163° C.

(2) Synthesis of 1-(2-pyridyl)imidazole-2-sulfonamide

A mixture consisting of 5.1 g of 1-(2-pyridyl)imidazole-2-thiol, 5.2 gof anhydrous potassium carbonate, 3.7 g of benzyl chloride and 50 ml ofacetonitrile was stirred at room temperature for 4 hours. Aftercompletion of the reaction, solids were filtered off and the filtratewas concentrated under reduced pressure. Crystals precipitated werecollected by filtration to give 7.1 g of2-benzylthio-1-(2-pyridyl)imidazole (m.p.: 76° to 77° C.). To a mixtureconsisting of 7.1 g of the thus obtained crystals, 50 ml of methylenechloride, 50 ml of water and 22 g of conc. hydrochloric acid was addeddropwise 80 g of 6% sodium hypochlorite solution under vigorous stirringat -10° to 0° C. over 1 hour. After completion of the dropwise addition,the resulting mixture was stirred at the same temperature for 30minutes. Then, the organic layer was separated and the aqueous layer wasextracted with methylene chloride. After the organic layers werecombined and washed with water, to the organic layer was added dropwise10 ml of a 28% aqueous ammonia under ice-cooling while vigorousstirring. After completion of the dropwise addition, the resultingmixture was stirred at room temperature for 1.5 hours. The reactionmixture was concentrated to dryness and the thus obtained concentratedresidue was extracted with ethyl acetate. The organic layer wasconcentrated under reduced pressure to give 3.0 g of a crude product ofthe desired compound. Crystals precipitated from the resulting crudeproduct were collected by filtration to give 0.8 g of the desiredcompound. m.p.: 187° to 188° C.

REFERENCE EXAMPLE 25 Synthesis of4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-sulfonamide

(1) Synthesis of 5-amino-4-ethoxycarbonyl-1-(2-pyridyl)imidazole

In 230 ml of acetonitrile, 8.5 g of ethyl α-aminocyanoacetate, 10.8 g ofethyl orthoformate and 6.2 g of 2-aminopyridine were heated under refluxfor 1.5 hours. After completion of the reaction, the solvent wasdistilled off under reduced pressure and crystals precipitated werefiltered off and washed with benzene to give 11.0 g of the desiredcompound. m.p.: 129° to 131° C.

(2) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-thiol

11.0 g of 5-amino-4-ethoxycarbonyl-1-(2-pyridyl)imidazole was dissolvedin 60 ml of conc. hydrochloric acid and the resulting solution wascooled to -5° C. Subsequently, 3.9 g of sodium nitrite was dissolved in10 ml of water and the resulting solution was added dropwise to thepreviously prepared solution while maintaining the temperature at -5° C.or lower. After completion of the dropwise addition, the resultingmixture was stirred at the same temperature for 0.5 hour. The thusobtained solution was added dropwise at around 5° C. to 150 ml of asolution of chloroform containing 1.0 g of cuprous chloride and 12 g ofsulfur dioxide. After the resulting mixture was stirred at roomtemperature for 1 hour, was added thereto 300 ml of water and theorganic layer was separated. The aqueous layer was extracted withchloroform and the organic layers were combined, washed with water anddried. The solvent was then removed by distillation to give 11.6 g of5-chloro-4-ethoxycarbonyl-1-(2-pyridyl)imidazole as an oil.

The thus obtained 11.6 g of 5-chloroimidazole derivative was dissolvedin 30 ml of dimethylformamide. To the resulting solution was added 9.2 gof sodium hydrosulfide (content of 70%), followed by stirring of theresulting mixture at room temperature for 1 hour. The reaction mixturewas poured into ice water and insolubles were filtered out. Then thefiltrate was made weakly acidic with use of conc. hydrochloric acid.Crystals precipitated were collected by filtration, washed with waterand dried to give 10.6 g of the desired compound. m.p.: 84° to 87° C.

(3) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-sulfonamide

To a mixture consisting of 10.6 g of4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-thiol, 50 ml of water, 100 mlof chloroform and 35.5 g of conc. hydrochloric acid, was added dropwise128 g of sodium hypochlorite solution (content of 6%) under vigorousstirring at -10° to 0° C. over 1 hour. After completion of the dropwiseaddition, the resulting mixture was stirred at the same temperature for0.5 hour. Then, the organic layer was separated and the aqueous layerwas extracted with chloroform. After the organic layers were combinedand washed with water, to the organic layer was added dropwise 10 ml of28% aqueous ammonia under ice-cooling, followed by stirring of theresulting mixture at room temperature for 1.5 hours. The reactionmixture was concentrated to dryness under reduced pressure and theresidue was extracted with ethyl acetate.

After the solvent was distilled off, crystals precipitated werecollected by filtration to give 4.1 g of the desired compound. m.p.:138° to 139° C.

Specific examples of synthesizing the present compounds using theintermediate obtained in the above Reference Examples will be givenbelow.

EXAMPLE 1 Synthesis ofN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-(4-chloro-1-methylpyrazol-3-yl)imidazole-2-sulfonamide

In 50 ml of acetonitrile, 2.8 g of1-(4-chloro-1-methylpyrazol-3-yl)imidazole-2-sulfonamide, 1,4 g of ethylchloroformate and 2.2 g of anhydrous potassium carbonate were heatedunder reflux for 2 hours. After completion of the reaction, the solventwas removed by distillation under reduced pressure and ice water wasadded to the residue and then extracted with chloroform. The aqueouslayer was separated and was made acidic with diluted hydrochloric acid.Crystals thus precipitated were filtered, washed with water and dried togive 2.1 g ofN-[1-(4-chloro-1-methylpyrazol-3-yl)imidazole-2-sulfonyl]ethylcarbamate. m.p.: 150° to 151° C.

0.7 g of ethyl carbamate thus obtained and 0.32 g of2-amino-4,6-dimethoxypyrimidine were refluxed under heating in 30 ml oftoluene for 2 hours while removing toluene by distillation little bylittle. After completion of the reaction, the residue was left forcooling and crystals precipitated were filtered out and washed withbenzene to give 0.6 g of the desired compound. m.p.: 164° to 165° C.

EXAMPLE 2 Synthesis ofN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-1-(2-pyridyl)imidazole-2-sulfonamide

In 15 ml of acetonitrile, 0.8 g of 1-(2-pyridyl)imidazole-2-sulfonamide,0.5 g of methyl chloroformate and 0.75 g of anhydrous potassiumcarbonate were refluxed under heating for 1 hour. After the reaction,the solvent was removed by distillation under reduced pressure and icewater was added to the residue, followed by extraction with methylenechloride. The aqueous layer was made weakly acidic with use of dilutedhydrochloric acid and concentrated under reduced pressure to precipitatecrystals. Crystals thus precipitated were filtered, washed with waterand dried to give 0.46 g of N-[1-(2-pyridyl)imidazole-2-sulfonyl]methylcarbamate. m.p.: 154° to 156° C.

0.46 g of methyl carbamate thus obtained and 0.25 g of2-amino-4,6-dimethoxypyrimidine were refluxed under heating in 30 ml oftoluene for 1.5 hours while removing toluene little by little bydistillation. After the reaction, the filtration was carried out duringhot. Crystals precipitated from the filtrate were filtered out to give0.3 g of the desired compound. m.p.: 146° to 149° C.

EXAMPLE 3 Synthesis ofN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide

0.23 g of 1,8-diazobicyclo(5,4,0)-7-undecene was added dropwise to amixture of 0.45 g of4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide, 0.41g of N-(4,6-dimethoxypyrimidine-2-yl)phenylcarbamate and 5 ml ofacetonitrile. After stirring the reaction mixture at room temperaturefor 20 minutes, 20 ml of ice water was added thereto and the mixture wasfiltered. The filtrate was made acidic with use of conc. hydrochloricacid, and resulting precipitated crystals were collected by filtration,washed with water and ethyl ether, and dried to obtain 0.45 g of thetitle compound. m.p.: 169° to 171° C.

Chemical structures and physical properties of compounds synthesizedaccording to Examples in addition to the compound synthesized inExamples will be given below. ##STR20##

Examples of compounds to be included in the compound of this inventionare shown below in Table 1 to Table 15 in addition to the compoundssynthesized in the above Example, which, however, should not beconstrued to limit this invention.

Be noted that the symbols in Tables have the meanings as shown below.

Me: methyl group, Et: ethyl group, Pr-n: n-propyl group, Pr-i: isopropylgroup, Ph: phenyl group

Gn represents the following groups.

Ga=G1 to G35, Gb=G1 to G6, Gc=G1 to G3 ##STR21##

Qn have the following meanings. ##STR22##

J1 to J14 each represent the following groups. ##STR23##

                  TABLE 1                                                         ______________________________________                                        A              B        D           Gn                                        ______________________________________                                        Q1             H        H           Gb                                        CH.sub.2 - Q1  H        H           Gc                                        CHMe- Q1       H        H           G3                                        Q2             H        H           Gb                                        Q3             H        H           Gb                                        Q4             H        H           Gb                                        Q5             H        H           Ga                                        CH.sub.2 - Q5  H        H           Gc                                        CHMe - Q5      H        H           G3                                        Q6             H        H           G3                                        Q7             H        H           G3                                        Q8             H        H           G3                                        Q9             H        H           Gc                                        CH.sub.2 - Q9  H        H           Gc                                        Q10            H        H           Gc                                        Q11            H        H           G3                                        Q12            H        H           G3                                        Q13            H        H           G3                                        Q14            H        H           G1                                        Q15            H        H           G3                                        Q16            H        H           Gc                                        Q17            H        H           Gc                                        Q18            H        H           G3                                        Q19            H        H           Gc                                        Q20            H        H           Gc                                        Q21            H        H           Gc                                        Q22            H        H           G3                                        Q23            H        H           Gc                                        CH.sub.2 - Q23 H        H           G3                                        Q24            H        H           Gc                                        Q25            H        H           Gb                                        Q26            H        H           Gb                                        CH.sub.2 - Q26 H        H           G3                                        CHMe - Q26     H        H           G3                                        Q27            H        H           G3                                        Q28            H        H           G3                                        Q29            H        H           Gc                                        CH.sub.2 - Q29 H        H           G3                                        Q30            H        H           G3                                        Q31            H        H           Gc                                        Q32            H        H           Gc                                        CH.sub.2 - Q32 H        H           G3                                        Q33            H        H           G3                                        Q34            H        H           G3                                        Q35            H        H           G3                                        Q36            H        H           G3                                        Q37            H        H           Gc                                        Q38            H        H           Gc                                        Q39            H        H           G3                                        Q40            H        H           Gc                                        Q41            H        H           Gc                                        Q42            H        H           Gc                                        Q43            H        H           G3                                        Q44            H        H           Gc                                        Q45            H        H           Gc                                        Q46            H        H           Gc                                        Q47            H        H           Gc                                        Q48            H        H           Gc                                        Q49            H        H           G3                                        Q50            H        H           Gc                                        CH.sub.2 - Q50 H        H           G3                                        Q51            H        H           Gc                                        Q52            H        H           G3                                        Q53            H        H           G3                                        Q54            H        H           Gc                                        Q55            H        H           Gc                                        Q56            H        H           Gc                                        Q57            H        H           G3                                        Q58            H        H           Gc                                        Q59            H        H           Gc                                        CH.sub.2 - Q59 H        H           G3                                        Q60            H        H           Gc                                        Q61            H        H           Ga                                        CH.sub.2 - Q61 H        H           Gb                                        CHMe - Q61     H        H           Gc                                        Q62            H        H           Gc                                        Q63            H        H           Gc                                        Q64            H        H           Gb                                        CH.sub.2 - Q64 H        H           G3                                        CHMe - Q64     H        H           G3                                        Q65            H        H           G3                                        Q66            H        H           G3                                        Q67            H        H           G3                                        Q68            H        H           G3                                        Q69            H        H           Gc                                        Q70            H        H           Gc                                        Q71            H        H           Gc                                        Q72            H        H           Gc                                        CH.sub.2 - Q72 H        H           G3                                        CHMe - Q72     H        H           G3                                        Q73            H        H           Gc                                        CH.sub.2 - Q73 H        H           G3                                        Q74            H        H           Gc                                        Q75            H        H           G3                                        Q76            H        H           G3                                        Q77            H        H           Gc                                        CH.sub.2 - Q77 H        H           G3                                        Q78            H        H           Gc                                        Q79            H        H           Gc                                        Q80            H        H           Gc                                        Q81            H        H           G3                                        Q82            H        H           G3                                        Q83            H        H           G1                                        Q84            H        H           G2                                        Q85            H        H           G3                                        Q86            H        H           Gc                                        Q87            H        H           G2                                        Q88            H        H           Gc                                        Q89            H        H           Gc                                        Q90            H        H           Gc                                        Q91            H        H           Gc                                        Q92            H        H           G3                                        Q93            H        H           Gc                                        Q94            H        H           G3                                        Q95            H        H           Gc                                        Q96            H        H           G3                                        Q97            H        H           Gc                                        Q98            H        H           Gc                                        Q99            H        H           Gc                                        Q100           H        H           Gc                                        Q101           H        H           Gc                                        CH.sub.2 - Q101                                                                              H        H           G3                                        Q102           H        H           G3                                        Q103           H        H           G3                                        Q104           H        H           G3                                        Q105           H        H           Gc                                        Q106           H        H           G3                                        Q107           H        H           Gc                                        Q108           H        H           G1                                        Q109           H        H           G3                                        Q110           H        H           G3                                        Q111           H        H           G3                                        Q112           H        H           Gc                                        Q113           H        H           Gc                                        Q114           H        H           Gc                                        Q115           H        H           G2                                        Q116           H        H           Gc                                        Q117           H        H           Gc                                        Q118           H        H           G3                                        Q119           H        H           Gc                                        Q120           H        H           Gc                                        Q121           H        H           G2                                        Q122           H        H           Gc                                        Q123           H        H           Gc                                        Q124           H        H           Gc                                        Q125           H        H           Gc                                        Q126           H        H           Gc                                        Q127           H        H           Gc                                        Q128           H        H           Gc                                        Q129           H        H           Gc                                        Q130           H        H           G2                                        Q131           H        H           Gc                                        Q132           H        H           Gc                                        Q133           H        H           G3                                        Q134           H        H           G3                                        Q135           H        H           Gc                                        Q136           H        H           G3                                        Q137           H        H           G1                                        Q138           H        H           Gc                                        CH.sub.2 - Q138                                                                              H        H           G3                                        Q139           H        H           G3                                        Q140           H        H           G1                                        Q141           H        H           G3                                        Q142           H        H           Gc                                        Q143           H        H           Gc                                        CH.sub.2 - Q143                                                                              H        H           G3                                        Q144           H        H           G3                                        Q145           H        H           Gc                                        Q146           H        H           Gc                                        Q147           H        H           G3                                        Q148           H        H           G1                                        Q149           H        H           G3                                        Q150           H        H           G3                                        Q151           H        H           G2                                        Q152           H        H           G1                                        Q153           H        H           Gc                                        Q154           H        H           Gc                                        Q155           H        H           G3                                        Q156           H        H           G3                                        Q157           H        H           Gc                                        Q158           H        H           Gc                                        CH.sub.2 - Q158                                                                              H        H           G3                                        CHMe - Q158    H        H           G3                                        Q159           H        H           G3                                        Q160           H        H           Gc                                        Q161           H        H           Gc                                        Q162           H        H           Gc                                        Q163           H        H           G3                                        Q164           H        H           Gc                                        Q165           H        H           Gc                                        Q166           H        H           Gc                                        Q167           H        H           G3                                        Q168           H        H           G3                                        Q169           H        H           Gc                                        CH.sub.2 - Q169                                                                              H        H           G3                                        CHMe - Q169    H        H           G3                                        Q170           H        H           Gc                                        Q171           H        H           Gc                                        Q172           H        H           Gc                                        Q173           H        H           Gc                                        Q174           H        H           Gc                                        Q175           H        H           Gc                                        Q176           H        H           Gc                                        Q177           H        H           Gc                                        CH.sub.2 - Q177                                                                              H        H           G3                                        CHMe - Q177    H        H           G3                                        Q178           H        H           G3                                        Q179           H        H           G3                                        Q180           H        H           Gc                                        CH.sub.2 - Q180                                                                              H        H           G3                                        Q181           H        H           G1                                        Q182           H        H           G3                                        Q183           H        H           G3                                        Q184           H        H           Gc                                        CH.sub.2 - Q184                                                                              H        H           G3                                        CHMe - Q184    H        H           G3                                        Q185           H        H           G3                                        Q186           H        H           G3                                        Q187           H        H           G3                                        Q188           H        H           Gb                                        Q189           H        H           Gb                                        Q1             H        Me          G3                                        Q2             H        Me          G3                                        Q4             H        Me          G3                                        Q5             H        Me          G3                                        Q7             H        Me          G3                                        Q9             H        Me          G3                                        Q10            H        Me          G3                                        Q19            H        Me          G3                                        Q23            H        Me          G3                                        Q26            H        Me          G3                                        Q32            H        Me          G3                                        Q41            H        Me          G3                                        Q45            H        Me          G3                                        Q50            H        Me          G3                                        Q61            H        Me          G3                                        Q69            H        Me          G3                                        Q79            H        Me          G3                                        Q83            H        Me          G3                                        Q96            H        Me          G3                                        Q124           H        Me          G3                                        Q131           H        Me          G3                                        Q132           H        Me          G3                                        Q135           H        Me          G3                                        Q138           H        Me          G3                                        Q142           H        Me          G3                                        Q157           H        Me          G3                                        Q158           H        Me          G3                                        Q159           H        Me          G3                                        Q177           H        Me          G3                                        Q180           H        Me          G3                                        Q184           H        Me          G3                                        Q188           H        Me          Gb                                        Q189           H        Me          Gb                                        Q1             Me       H           G3                                        Q2             Me       H           G3                                        Q4             Me       H           G3                                        Q5             Me       H           G3                                        Q7             Me       H           G3                                        Q9             Me       H           G3                                        Q10            Me       H           G3                                        Q19            Me       H           G3                                        Q23            Me       H           G3                                        Q26            Me       H           G3                                        Q32            Me       H           G3                                        Q41            Me       H           G3                                        Q45            Me       H           G3                                        Q50            Me       H           G3                                        Q61            Me       H           G3                                        Q69            Me       H           G3                                        Q79            Me       H           G3                                        Q83            Me       H           G3                                        Q96            Me       H           G3                                        Q124           Me       H           G3                                        Q131           Me       H           G3                                        Q132           Me       H           G3                                        Q135           Me       H           G3                                        Q138           Me       H           G3                                        Q142           Me       H           G3                                        Q157           Me       H           G3                                        Q158           Me       H           G3                                        Q159           Me       H           G3                                        Q177           Me       H           G3                                        Q180           Me       H           G3                                        Q184           Me       H           G3                                        Q188           Me       H           Gb                                        Q189           Me       H           Gb                                        Q4             Me       Me          G3                                        Q5             Me       Me          G3                                        Q7             Me       Me          G3                                        Q9             Me       Me          G3                                        Q23            Me       Me          G3                                        Q26            Me       Me          G3                                        Q32            Me       Me          G3                                        Q61            Me       Me          G3                                        Q96            Me       Me          G3                                        Q142           Me       Me          G3                                        Q158           Me       Me          G3                                        Q188           Me       Me          Gb                                        Q189           Me       Me          Gb                                        Q201           H        H           Ga                                        CH.sub.2 - Q201                                                                              H        H           Ga                                        CHMe - Q201    H        H           Gc                                        Q202           H        H           Gb                                        Q203           H        H           Gb                                        Q204           H        H           Gb                                        Q205           H        H           Gb                                        CH.sub.2 - Q205                                                                              H        H           Gc                                        Q206           H        H           G3                                        Q207           H        H           Gc                                        Q208           H        H           G3                                        Q209           H        H           Gc                                        CH.sub.2 - Q209                                                                              H        H           Gc                                        Q210           H        H           Gc                                        Q211           H        H           G3                                        Q212           H        H           Gc                                        Q213           H        H           Gc                                        Q214           H        H           G1                                        Q215           H        H           Gc                                        Q216           H        H           Gc                                        Q217           H        H           Gc                                        Q218           H        H           G3                                        Q219           H        H           Gc                                        Q220           H        H           Gc                                        Q221           H        H           G2                                        Q222           H        H           Gb                                        CH.sub.2 - Q222                                                                              H        H           Gc                                        Q223           H        H           G3                                        Q224           H        H           Gc                                        Q225           H        H           Gb                                        CH.sub.2 - Q225                                                                              H        H           Gc                                        Q226           H        H           G3                                        Q227           H        H           Gc                                        Q228           H        H           Gc                                        Q229           H        H           Gb                                        CH.sub.2 - Q229                                                                              H        H           Gc                                        Q230           H        H           Gc                                        Q231           H        H           Gc                                        CH.sub.2 - Q231                                                                              H        H           Gc                                        Q232           H        H           Gc                                        Q233           H        H           G3                                        Q234           H        H           Gc                                        Q235           H        H           Gc                                        Q236           H        H           G1                                        Q237           H        H           Gc                                        Q238           H        H           Gc                                        Q239           H        H           G3                                        Q240           H        H           Gc                                        Q241           H        H           Gc                                        Q242           H        H           Gc                                        Q243           H        H           G3                                        Q244           H        H           Gc                                        Q245           H        H           Gc                                        Q246           H        H           Gb                                        CH.sub.2 - Q246                                                                              H        H           Gc                                        Q247           H        H           Gc                                        Q248           H        H           G2                                        Q249           H        H           Gc                                        Q250           H        H           Gc                                        CH.sub.2 - Q250                                                                              H        H           Gc                                        Q251           H        H           Gc                                        Q252           H        H           G3                                        Q253           H        H           Gc                                        Q254           H        H           Gc                                        Q255           H        H           Gc                                        Q256           H        H           G2                                        Q257           H        H           Gc                                        Q258           H        H           Gc                                        Q259           H        H           Gc                                        CH.sub.2 - Q259                                                                              H        H           G3                                        Q260           H        H           Gc                                        CH.sub.2 - Q60 H        H           Gc                                        Q261           H        H           G1                                        Q262           H        H           Gc                                        Q263           H        H           Gc                                        Q264           H        H           G1                                        Q201           H        Me          Gc                                        Q202           H        Me          G3                                        Q205           H        Me          Gc                                        Q209           H        Me          G1                                        Q222           H        Me          Gc                                        Q225           H        Me          G3                                        Q229           H        Me          Gc                                        Q231           H        Me          Gc                                        Q246           H        Me          G3                                        Q260           H        Me          Gc                                        Q201           Me       H           Gc                                        Q202           Me       H           G3                                        Q205           Me       H           Gc                                        Q209           Me       H           Gc                                        Q222           Me       H           Gc                                        Q225           Me       H           G2                                        Q229           Me       H           Gc                                        Q231           Me       H           Gc                                        Q246           Me       H           G1                                        Q260           Me       H           Gc                                        Q201           Me       Me          Gc                                        Q202           Me       Me          G3                                        Q205           Me       Me          Gc                                        Q209           Me       Me          G3                                        Q222           Me       Me          Gc                                        Q225           Me       Me          Gc                                        Q229           Me       Me          Gc                                        Q231           Me       Me          G1                                        Q246           Me       Me          Gc                                        Q260           Me       Me          G3                                        Q201           C1       H           Gc                                        Q205           C1       H           Gc                                        Q222           C1       H           G3                                        Q229           C1       H           Gc                                        Q201           H        C1          Gc                                        Q205           H        C1          G1                                        Q201           C1       Me          Gc                                        Q205           C1       Me          Gc                                        Q201           C1       C1          Gc                                        Q205           C1       C1          Gc                                        Q222           C1       C1          G3                                        Q229           C1       C1          Gc                                        Q201           Br       H           Gc                                        Q205           Br       H           Gc                                        Q222           Br       H           G2                                        Q229           Br       H           Gc                                        Q201           H        Br          Gc                                        Q205           H        Br          G3                                        Q201           Br       Me          Gc                                        Q205           Br       Me          G3                                        Q201           Br       Br          Gc                                        Q205           Br       Br          G3                                        Q6             H        Me          Gb                                        Q15            H        Me          Gc                                        Q21            H        Me          G3                                        Q29            H        Me          Gb                                        Q54            H        Me          Gb                                        Q68            H        Me          Gb                                        Q88            H        Me          G3                                        Q127           H        Me          G3                                        Q204           H        Me          G3                                        Q230           H        Me          G3                                        Q250           H        Me          G3                                        Q5             H        C1          G3                                        Q6             H        C1          G3                                        Q7             H        C1          G3                                        Q9             H        C1          G3                                        Q15            H        C1          G3                                        Q21            H        C1          G3                                        Q26            H        C1          G3                                        Q29            H        C1          G3                                        Q32            H        C1          G3                                        Q50            H        C1          G3                                        Q54            H        C1          G3                                        Q61            H        C1          G3                                        Q68            H        C1          G3                                        Q88            H        C1          G3                                        Q127           H        C1          G3                                        Q138           H        C1          G3                                        Q142           H        C1          G3                                        Q188           H        C1          G3                                        Q189           H        C1          G3                                        Q202           H        C1          G3                                        Q204           H        C1          G3                                        Q209           H        C1          G3                                        Q222           H        C1          G3                                        Q225           H        C1          G3                                        Q229           H        C1          G3                                        Q230           H        C1          G3                                        Q246           H        C1          G3                                        Q250           H        C1          G3                                        Q5             H        NO.sub.2    G3                                        Q6             H        NHCOMe      G3                                        Q7             H        NO.sub.2    G3                                        Q9             H        NO.sub.2    G3                                        Q15            H        NMe.sub.2   G3                                        Q21            H        NMe.sub.2   G3                                        Q26            H        NHCOMe      G3                                        Q29            H        NO.sub.2    G3                                        Q32            H        NMe.sub.2   G3                                        Q50            H        NO.sub.2    G3                                        Q54            H        NMe.sub.2   G3                                        Q61            H        NO.sub.2    G3                                        Q68            H        NO.sub.2    G3                                        Q88            H        NO.sub.2    G3                                        Q127           H        NMe.sub.2   G3                                        Q138           H        NHCOMe      G3                                        Q142           H        NO.sub.2    G3                                        Q188           H        NO.sub.2    G3                                        Q189           H        NO.sub.2    G3                                        Q201           H        NMe.sub.2   G3                                        Q202           H        NHCOMe      G3                                        Q204           H        NO.sub.2    G3                                        Q205           H        NHCOMe      G3                                        Q209           H        NMe.sub.2   G3                                        Q222           H        NO.sub.2    G3                                        Q225           H        NMe.sub.2   G3                                        Q229           H        NHCOMe      G3                                        Q230           H        NO.sub.2    G3                                        Q246           H        NMe.sub.2   G3                                        Q250           H        NO.sub.2    G3                                        ______________________________________                                    

                  TABLE 2                                                         ______________________________________                                         ##STR24##                                                                    A            B        D              Gn                                       ______________________________________                                        Q1           H        COOMe          Gb                                       CH.sub.2 - Q1                                                                              H        COOMe          Gc                                       CHMe - Q1    H        COOMe          G3                                       Q2           H        COOMe          Gb                                       Q3           H        COOMe          Gb                                       Q4           H        COOMe          Gb                                       Q5           H        COOMe          Ga                                       CH.sub.2 - Q5                                                                              H        COOMe          Gc                                       CHMe - Q5    H        COOMe          G3                                       Q6           H        COOMe          G3                                       Q7           H        COOMe          G3                                       Q8           H        COOMe          G3                                       Q9           H        COOMe          Gc                                       CH.sub.2 - Q9                                                                              H        COOMe          Gc                                       Q10          H        COOMe          Gc                                       Q11          H        COOMe          G3                                       Q12          H        COOMe          G3                                       Q13          H        COOMe          G3                                       Q14          H        COOMe          G1                                       Q15          H        COOMe          G3                                       Q16          H        COOMe          Gc                                       Q17          H        COOMe          Gc                                       Q18          H        COOMe          G3                                       Q19          H        COOMe          Gc                                       Q20          H        COOMe          Gc                                       Q21          H        COOMe          Gc                                       Q22          H        COOMe          G3                                       Q23          H        COOMe          Gc                                       CH.sub.2 - Q23                                                                             H        COOMe          G3                                       Q24          H        COOMe          Gc                                       Q25          H        COOMe          Gb                                       Q26          H        COOMe          Ga                                       CH.sub.2 - Q26                                                                             H        COOMe          G3                                       CHMe - Q26   H        COOMe          G3                                       Q27          H        COOMe          G3                                       Q28          H        COOMe          G3                                       Q29          H        COOMe          Gc                                       CH.sub.2 - Q29                                                                             H        COOMe          G3                                       Q30          H        COOMe          G3                                       Q31          H        COOMe          Gc                                       Q32          H        COOMe          Gc                                       CH.sub.2 - Q32                                                                             H        COOMe          G3                                       Q33          H        COOMe          G3                                       Q34          H        COOMe          G3                                       Q35          H        COOMe          G3                                       Q36          H        COOMe          G3                                       Q37          H        COOMe          Gc                                       Q38          H        COOMe          Gc                                       Q39          H        COOMe          G3                                       Q40          H        COOMe          Gc                                       Q41          H        COOMe          Gc                                       Q42          H        COOMe          Gc                                       Q43          H        COOMe          G3                                       Q44          H        COOMe          Gc                                       Q45          H        COOMe          Gc                                       Q46          H        COOMe          Gc                                       Q47          H        COOMe          Gc                                       Q48          H        COOMe          Gc                                       Q49          H        COOMe          G3                                       Q50          H        COOMe          Gc                                       CH.sub.2 - Q50                                                                             H        COOMe          G3                                       Q51          H        COOMe          Gc                                       Q52          H        COOMe          G3                                       Q53          H        COOMe          G3                                       Q54          H        COOMe          Gc                                       Q55          H        COOMe          Gc                                       Q56          H        COOMe          Gc                                       Q57          H        COOMe          G3                                       Q58          H        COOMe          Gc                                       Q59          H        COOMe          Gc                                       CH.sub.2 - Q59                                                                             H        COOMe          G3                                       Q60          H        COOMe          Gc                                       Q61          H        COOMe          Ga                                       CH.sub.2 - Q61                                                                             H        COOMe          Gb                                       CHMe - Q61   H        COOMe          Gc                                       Q62          H        COOMe          Gc                                       Q63          H        COOMe          Gc                                       Q64          H        COOMe          Gb                                       CH.sub.2 - Q64                                                                             H        COOMe          G3                                       CHMe - Q64   H        COOMe          G3                                       Q65          H        COOMe          G3                                       Q66          H        COOMe          G3                                       Q67          H        COOMe          G3                                       Q68          H        COOMe          G3                                       Q69          H        COOMe          Gc                                       Q70          H        COOMe          Gc                                       Q71          H        COOMe          Gc                                       Q72          H        COOMe          Gc                                       CH.sub.2 - Q72                                                                             H        COOMe          G3                                       CHMe - Q72   H        COOMe          G3                                       Q73          H        COOMe          Gc                                       CH.sub.2 - Q73                                                                             H        COOMe          G3                                       Q74          H        COOMe          Gc                                       Q75          H        COOMe          G3                                       Q76          H        COOMe          G3                                       Q77          H        COOMe          Gc                                       CH.sub.2 - Q77                                                                             H        COOMe          G3                                       Q78          H        COOMe          Gc                                       Q79          H        COOMe          Gc                                       Q80          H        COOMe          Gc                                       Q81          H        COOMe          G3                                       Q82          H        COOMe          G3                                       Q83          H        COOMe          G1                                       Q84          H        COOMe          G2                                       Q85          H        COOMe          G3                                       Q86          H        COOMe          Gc                                       Q87          H        COOMe          G2                                       Q88          H        COOMe          Gc                                       Q89          H        COOMe          Gc                                       Q90          H        COOMe          Gc                                       Q91          H        COOMe          Gc                                       Q92          H        COOMe          G3                                       Q93          H        COOMe          Gc                                       Q94          H        COOMe          G3                                       Q95          H        COOMe          Gc                                       Q96          H        COOMe          G3                                       Q97          H        COOMe          Gc                                       Q98          H        COOMe          Gc                                       Q99          H        COOMe          Gc                                       Q100         H        COOMe          Gc                                       Q101         H        COOMe          Gc                                       CH.sub. 2 - Q101                                                                           H        COOMe          G3                                       Q102         H        COOMe          G3                                       Q103         H        COOMe          G3                                       Q104         H        COOMe          G3                                       Q105         H        COOMe          Gc                                       Q106         H        COOMe          G3                                       Q107         H        COOMe          Gc                                       Q108         H        COOMe          G1                                       Q109         H        COOMe          G3                                       Q110         H        COOMe          G3                                       Q111         H        COOMe          G3                                       Q112         H        COOMe          Gc                                       Q113         H        COOMe          Gc                                       Q114         H        COOMe          Gc                                       Q115         H        COOMe          G2                                       Q116         H        COOMe          Gc                                       Q117         H        COOMe          Gc                                       Q118         H        COOMe          G3                                       Q119         H        COOMe          Gc                                       Q120         H        COOMe          Gc                                       Q121         H        COOMe          G2                                       Q122         H        COOMe          Gc                                       Q123         H        COOMe          Gc                                       Q124         H        COOMe          Gc                                       Q125         H        COOMe          Gc                                       Q126         H        COOMe          Gc                                       Q127         H        COOMe          Gc                                       Q128         H        COOMe          Gc                                       Q129         H        COOMe          Gc                                       Q130         H        COOMe          G2                                       Q131         H        COOMe          Gc                                       Q132         H        COOMe          Gc                                       Q133         H        COOMe          G3                                       Q134         H        COOMe          G3                                       Q135         H        COOMe          Gc                                       Q136         H        COOMe          G3                                       Q137         H        COOMe          G1                                       Q138         H        COOMe          Gc                                       CH.sub.2 - Q138                                                                            H        COOMe          G3                                       Q139         H        COOMe          G3                                       Q140         H        COOMe          G1                                       Q141         H        COOMe          G3                                       Q142         H        COOMe          Gc                                       Q143         H        COOMe          Gc                                       CH.sub.2 - Q143                                                                            H        COOMe          G3                                       Q144         H        COOMe          G3                                       Q145         H        COOMe          Gc                                       Q146         H        COOMe          Gc                                       Q147         H        COOMe          G3                                       Q148         H        COOMe          G1                                       Q149         H        COOMe          G3                                       Q150         H        COOMe          G3                                       Q151         H        COOMe          G2                                       Q152         H        COOMe          G1                                       Q153         H        COOMe          Gc                                       Q154         H        COOMe          Gc                                       Q155         H        COOMe          G3                                       Q156         H        COOMe          G3                                       Q157         H        COOMe          Gc                                       Q158         H        COOMe          Ga                                       CH.sub.2 - Q158                                                                            H        COOMe          G3                                       CHMe - Q158  H        COOMe          G3                                       Q159         H        COOMe          G3                                       Q160         H        COOMe          Gc                                       Q161         H        COOMe          Gc                                       Q162         H        COOMe          Gc                                       Q163         H        COOMe          G3                                       Q164         H        COOMe          Gc                                       Q165         H        COOMe          Gc                                       Q166         H        COOMe          Gc                                       Q167         H        COOMe          G3                                       Q168         H        COOMe          G3                                       Q169         H        COOMe          Gc                                       CH.sub.2 - Q169                                                                            H        COOMe          G3                                       CHMe - Q169  H        COOMe          G3                                       Q170         H        COOMe          Gc                                       Q171         H        COOMe          Gc                                       Q172         H        COOMe          Gc                                       Q173         H        COOMe          Gc                                       Q174         H        COOMe          Gc                                       Q175         H        COOMe          Gc                                       Q176         H        COOMe          Gc                                       Q177         H        COOMe          Gc                                       CH.sub.2 - Q177                                                                            H        COOMe          G3                                       CHMe - Q177  H        COOMe          G3                                       Q178         H        COOMe          G3                                       Q179         H        COOMe          G3                                       Q180         H        COOMe          Gc                                       CH.sub.2 - Q180                                                                            H        COOMe          G3                                       Q181         H        COOMe          G1                                       Q182         H        COOMe          G3                                       Q183         H        COOMe          G3                                       Q184         H        COOMe          Gc                                       CH.sub.2 - Q184                                                                            H        COOMe          G3                                       CHMe - Q184  H        COOMe          G3                                       Q185         H        COOMe          G3                                       Q186         H        COOMe          G3                                       Q187         H        COOMe          G3                                       Q188         H        COOMe          Gb                                       Q189         H        COOMe          Gb                                       Q1           H        COOEt          Gb                                       CH.sub.2 - Q1                                                                              H        COOEt          Gc                                       CHMe - Q1    H        COOEt          G3                                       Q2           H        COOEt          Gb                                       Q3           H        COOEt          Gb                                       Q4           H        COOEt          Gb                                       Q5           H        COOEt          Ga                                       CH.sub.2 - Q5                                                                              H        COOEt          Gc                                       CHMe - Q5    H        COOEt          G3                                       Q6           H        COOEt          G3                                       Q7           H        COOEt          G3                                       Q8           H        COOEt          G3                                       Q9           H        COOEt          Gc                                       CH.sub.2 - Q9                                                                              H        COOEt          Gc                                       Q10          H        COOEt          Gc                                       Q11          H        COOEt          G3                                       Q12          H        COOEt          G3                                       Q13          H        COOEt          G3                                       Q14          H        COOEt          G1                                       Q15          H        COOEt          G3                                       Q16          H        COOEt          Gc                                       Q17          H        COOEt          Gc                                       Q18          H        COOEt          G3                                       Q19          H        COOEt          Gc                                       Q20          H        COOEt          Gc                                       Q21          H        COOEt          Gc                                       Q22          H        COOEt          G3                                       Q23          H        COOEt          Gc                                       CH.sub.2 - Q23                                                                             H        COOEt          G3                                       Q24          H        COOEt          Gc                                       Q25          H        COOEt          Gb                                       Q26          H        COOEt          Ga                                       CH.sub.2 - Q26                                                                             H        COOEt          G3                                       CHMe - Q26   H        COOEt          G3                                       Q27          H        COOEt          G3                                       Q28          H        COOEt          G3                                       Q29          H        COOEt          Gc                                       CH.sub.2 - Q29                                                                             H        COOEt          G3                                       Q30          H        COOEt          G3                                       Q31          H        COOEt          Gc                                       Q32          H        COOEt          Gc                                       CH.sub.2 - Q32                                                                             H        COOEt          G3                                       Q33          H        COOEt          G3                                       Q34          H        COOEt          G3                                       Q35          H        COOEt          G3                                       Q36          H        COOEt          G3                                       Q37          H        COOEt          Gc                                       Q38          H        COOEt          Gc                                       Q39          H        COOEt          G3                                       Q40          H        COOEt          Gc                                       Q41          H        COOEt          Gc                                       Q42          H        COOEt          Gc                                       Q43          H        COOEt          G3                                       Q44          H        COOEt          Gc                                       Q45          H        COOEt          Gc                                       Q46          H        COOEt          Gc                                       Q47          H        COOEt          Gc                                       Q48          H        COOEt          Gc                                       Q49          H        COOEt          G3                                       Q50          H        COOEt          Gc                                       CH.sub.2 - Q50                                                                             H        COOEt          G3                                       Q51          H        COOEt          Gc                                       Q52          H        COOEt          G3                                       Q53          H        COOEt          G3                                       Q54          H        COOEt          Gc                                       Q55          H        COOEt          Gc                                       Q56          H        COOEt          Gc                                       Q57          H        COOEt          G3                                       Q58          H        COOEt          Gc                                       Q59          H        COOEt          Gc                                       CH.sub.2 - Q59                                                                             H        COOEt          G3                                       Q60          H        COOEt          Gc                                       Q61          H        COOEt          Ga                                       CH.sub.2 - Q61                                                                             H        COOEt          Gb                                       CHMe - Q61   H        COOEt          Gc                                       Q62          H        COOEt          Gc                                       Q63          H        COOEt          Gc                                       Q64          H        COOEt          Gb                                       CH.sub. 2 - Q64                                                                            H        COOEt          G3                                       CHMe - Q64   H        COOEt          G3                                       Q65          H        COOEt          G3                                       Q66          H        COOEt          G3                                       Q67          H        COOEt          G3                                       Q68          H        COOEt          G3                                       Q69          H        COOEt          Gc                                       Q70          H        COOEt          Gc                                       Q71          H        COOEt          Gc                                       Q72          H        COOEt          Gc                                       CH.sub.2 - Q72                                                                             H        COOEt          G3                                       CHMe - Q72   H        COOEt          G3                                       Q73          H        COOEt          Gc                                       CH.sub.2 - Q73                                                                             H        COOEt          G3                                       Q74          H        COOEt          Gc                                       Q75          H        COOEt          G3                                       Q76          H        COOEt          G3                                       Q77          H        COOEt          Gc                                       CH.sub.2 - Q77                                                                             H        COOEt          G3                                       Q78          H        COOEt          Gc                                       Q79          H        COOEt          Gc                                       Q80          H        COOEt          Gc                                       Q81          H        COOEt          G3                                       Q82          H        COOEt          G3                                       Q83          H        COOEt          G1                                       Q84          H        COOEt          G2                                       Q85          H        COOEt          G3                                       Q86          H        COOEt          Gc                                       Q87          H        COOEt          G2                                       Q88          H        COOEt          Gc                                       Q89          H        COOEt          Gc                                       Q90          H        COOEt          Gc                                       Q91          H        COOEt          Gc                                       Q92          H        COOEt          G3                                       Q93          H        COOEt          Gc                                       Q94          H        COOEt          G3                                       Q95          H        COOEt          Gc                                       Q96          H        COOEt          G3                                       Q97          H        COOEt          Gc                                       Q98          H        COOEt          Gc                                       Q99          H        COOEt          Gc                                       Q100         H        COOEt          Gc                                       Q101         H        COOEt          Gc                                       CH.sub.2 - Q101                                                                            H        COOEt          G3                                       Q102         H        COOEt          G3                                       Q103         H        COOEt          G3                                       Q104         H        COOEt          G3                                       Q105         H        COOEt          Gc                                       Q106         H        COOEt          G3                                       Q107         H        COOEt          Gc                                       Q108         H        COOEt          G1                                       Q109         H        COOEt          G3                                       Q110         H        COOEt          G3                                       Q111         H        COOEt          G3                                       Q112         H        COOEt          Gc                                       Q113         H        COOEt          Gc                                       Q114         H        COOEt          Gc                                       Q115         H        COOEt          G2                                       Q116         H        COOEt          Gc                                       Q117         H        COOEt          Gc                                       Q118         H        COOEt          G3                                       Q119         H        COOEt          Gc                                       Q120         H        COOEt          Gc                                       Q121         H        COOEt          G2                                       Q122         H        COOEt          Gc                                       Q123         H        COOEt          Gc                                       Q124         H        COOEt          Gc                                       Q125         H        COOEt          Gc                                       Q126         H        COOEt          Gc                                       Q127         H        COOEt          Gc                                       Q128         H        COOEt          Gc                                       Q129         H        COOEt          Gc                                       Q130         H        COOEt          G2                                       Q131         H        COOEt          Gc                                       Q132         H        COOEt          Gc                                       Q133         H        COOEt          G3                                       Q134         H        COOEt          G3                                       Q135         H        COOEt          Gc                                       Q136         H        COOEt          G3                                       Q137         H        COOEt          G1                                       Q138         H        COOEt          Gc                                       CH.sub.2 - Q138                                                                            H        COOEt          G3                                       Q139         H        COOEt          G3                                       Q140         H        COOEt          G1                                       Q141         H        COOEt          G3                                       Q142         H        COOEt          Gc                                       Q143         H        COOEt          Gc                                       CH.sub.2 - Q143                                                                            H        COOEt          G3                                       Q144         H        COOEt          G3                                       Q145         H        COOEt          Gc                                       Q146         H        COOEt          Gc                                       Q147         H        COOEt          G3                                       Q148         H        COOEt          G1                                       Q149         H        COOEt          G3                                       Q150         H        COOEt          G3                                       Q151         H        COOEt          G2                                       Q152         H        COOEt          G1                                       Q153         H        COOEt          Gc                                       Q154         H        COOEt          Gc                                       Q155         H        COOEt          G3                                       Q156         H        COOEt          G3                                       Q157         H        COOEt          Gc                                       Q158         H        COOEt          Ga                                       CH.sub.2 - Q158                                                                            H        COOEt          G3                                       CHMe - Q158  H        COOEt          G3                                       Q159         H        COOEt          G3                                       Q160         H        COOEt          Gc                                       Q161         H        COOEt          Gc                                       Q162         H        COOEt          Gc                                       Q163         H        COOEt          G3                                       Q164         H        COOEt          Gc                                       Q165         H        COOEt          Gc                                       Q166         H        COOEt          Gc                                       Q167         H        COOEt          G3                                       Q168         H        COOEt          G3                                       Q169         H        COOEt          Gc                                       CH.sub.2 - Q169                                                                            H        COOEt          G3                                       CHMe - Q169  H        COOEt          G3                                       Q170         H        COOEt          Gc                                       Q171         H        COOEt          Gc                                       Q172         H        COOEt          Gc                                       Q173         H        COOEt          Gc                                       Q174         H        COOEt          Gc                                       Q175         H        COOEt          Gc                                       Q176         H        COOEt          Gc                                       Q177         H        COOEt          Gc                                       CH.sub.2 - Q177                                                                            H        COOEt          G3                                       CHMe - Q177  H        COOEt          G3                                       Q178         H        COOEt          G3                                       Q179         H        COOEt          G3                                       Q180         H        COOEt          Gc                                       CH.sub.2 - Q180                                                                            H        COOEt          G3                                       Q181         H        COOEt          G1                                       Q182         H        COOEt          G3                                       Q183         H        COOEt          G3                                       Q184         H        COOEt          Gc                                       CH.sub.2  - Q184                                                                           H        COOEt          G3                                       CHMe - Q184  H        COOEt          G3                                       Q185         H        COOEt          G3                                       Q186         H        COOEt          G3                                       Q187         H        COOEt          G3                                       Q188         H        COOEt          Gb                                       Q189         H        COOEt          Gb                                       Q5           H        COOPri         G3                                       Q26          H        COOPri         G3                                       Q61          H        COOPri         G3                                       Q158         H        COOPri         G3                                       Q5           H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q61          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q158         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q26          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q61          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           H        COOCH.sub.2 C CH                                                                             G3                                       Q26          H        COOCH.sub.2 C CH                                                                             G3                                       Q61          H        COOCH.sub.2 C CH                                                                             G3                                       Q158         H        COOCH.sub.2 C CH                                                                             G3                                       Q1           H        COOPri         G3                                       Q2           H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q4           H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q7           H        COOCH.sub.2 C CH                                                                             G3                                       Q9           H        COOPri         G3                                       Q10          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q19          H        COOPri         G3                                       Q23          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q32          H        COOCH.sub.2 C CH                                                                             G3                                       Q41          H        COOPri         G3                                       Q45          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q50          H        COOCH.sub.2 C CH                                                                             G3                                       Q69          H        COOPri         G3                                       Q79          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q83          H        COOCH.sub.2 C CH                                                                             G3                                       Q96          H        COOPri         G3                                       Q124         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q131         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q132         H        COOCH.sub.2 C CH                                                                             G3                                       Q135         H        COOPri         G3                                       Q138         H        COOPri         G3                                       Q142         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q157         H        COOPri         G3                                       Q159         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q177         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q180         H        COOCH.sub.2 C CH                                                                             G3                                       Q184         H        COOPri         G3                                       Q5           H        COOH           G3                                       Q26          H        COOH           G3                                       Q61          H        COOH           G3                                       Q158         H        COOH           G3                                       Q5           H        CONHMe         G3                                       Q26          H        CONHMe         G3                                       Q61          H        CONHMe         G3                                       Q158         H        CONHMe         G3                                       Q5           H        CONMe.sub.2    G3                                       Q26          H        CONMe.sub.2    G3                                       Q61          H        CONMe.sub.2    G3                                       Q158         H        CONMe.sub.2    G3                                       Q5           H        COMe           G3                                       Q26          H        COMe           G3                                       Q61          H        COMe           G3                                       Q158         H        COMe           G3                                       Q189         H        COMe           Gb                                       Q5           H        COEt           G3                                       Q26          H        COEt           G3                                       Q61          H        COEt           G3                                       Q158         H        COEt           G3                                       Q189         H        COEt           Gb                                       Q5           H        COPri          G3                                       Q26          H        COPri          G3                                       Q61          H        COPri          G3                                       Q158         H        COPri          G3                                       Q5           H        COPh           G3                                       Q26          H        COPh           G3                                       Q61          H        COPh           G3                                       Q158         H        COPh           G3                                       Q1           H        COMe           G3                                       Q2           H        COEt           G3                                       Q4           H        COMe           G3                                       Q7           H        COMe           G3                                       Q9           H        COEt           G3                                       Q10          H        COPri          G3                                       Q19          H        COPh           G3                                       Q23          H        COMe           G3                                       Q32          H        COMe           G3                                       Q41          H        COPri          G3                                       Q45          H        COPh           G3                                       Q50          H        COMe           G3                                       Q69          H        COEt           G3                                       Q79          H        COPri          G3                                       Q83          H        COPh           G3                                       Q96          H        COMe           G3                                       Q124         H        COEt           G3                                       Q131         H        COMe           G3                                       Q132         H        COMe           G3                                       Q135         H        COEt           G3                                       Q138         H        COPri          G3                                       Q142         H        COPh           G3                                       Q157         H        COMe           G3                                       Q159         H        COEt           G3                                       Q177         H        COMe           G3                                       Q180         H        COMe           G3                                       Q184         H        COPri          G3                                       Q4           H        CN             G3                                       Q5           H        CN             G3                                       Q7           H        CN             G3                                       Q9           H        CN             G3                                       Q23          H        CN             G3                                       Q26          H        CN             G3                                       Q32          H        CN             G3                                       Q61          H        CN             G3                                       Q96          H        CN             G3                                       Q142         H        CN             G3                                       Q158         H        CN             G3                                       Q5           H        H              G3                                       Q26          H        H              G3                                       Q61          H        H              G3                                       Q158         H        H              G3                                       Q5           H        Me             G3                                       Q26          H        Me             G3                                       Q61          H        Me             G3                                       Q158         H        Me             G3                                       Q5           H        Et             G3                                       Q26          H        Et             G3                                       Q61          H        Et             G3                                       Q158         H        Et             G3                                       Q5           H        Pri            G3                                       Q26          H        Pri            G3                                       Q61          H        Pri            G3                                       Q158         H        Pri            G3                                       Q5           H        CHCH.sub.2     G3                                       Q26          H        CHCH.sub.2     G3                                       Q61          H        CHCHMe         G3                                       Q158         H        CHCHMe         G3                                       Q5           H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q26          H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q61          H        CH.sub.2 CHCH.sub. 2                                                                         G3                                       Q158         H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q1           H        H              G3                                       Q2           H        Me             G3                                       Q4           H        Me             G3                                       Q7           H        Me             G3                                       Q9           H        Et             G3                                       Q10          H        Pri            G3                                       Q19          H        Me             G3                                       Q23          H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q32          H        H              G3                                       Q41          H        Me             G3                                       Q45          H        Me             G3                                       Q50          H        Et             G3                                       Q69          H        Pri            G3                                       Q79          H        Me             G3                                       Q83          H        Et             G3                                       Q96          H        Me             G3                                       Q124         H        Et             G3                                       Q131         H        Me             G3                                       Q132         H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q135         H        Et             G3                                       Q138         H        Pri            G3                                       Q142         H        H              G3                                       Q157         H        Me             G3                                       Q159         H        Me             G3                                       Q177         H        H              G3                                       Q180         H        Me             G3                                       Q184         H        Me             G3                                       Q5           H        CH.sub.2 Cl    G3                                       Q26          H        CH.sub.2 Cl    G3                                       Q61          H        CH.sub.2 Cl    G3                                       Q158         H        CH.sub.2 Cl    G3                                       Q5           H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q61          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q5           H        CF.sub.3       G3                                       Q26          H        CF.sub.3       G3                                       Q61          H        CF.sub.3       G3                                       Q158         H        CF.sub.3       G3                                       Q5           H        CFCFCl         G3                                       Q26          H        CFCFCl         G3                                       Q61          H        CH.sub.2 Ph    G3                                       Q158         H        CH.sub.2 Ph    G3                                       Q5           H        Ph             G3                                       Q26          H        Ph             G3                                       Q61          H        Ph             G3                                       Q158         H        Ph             G3                                       Q5           H        Ph2-Cl         G3                                       Q26          H        Ph2-Me         G3                                       Q61          H        Ph2-Cl         G3                                       Q158         H        Ph2-Me         G3                                       Q1           H        Ph             G3                                       Q2           H        CH.sub.2 Cl    G3                                       Q4           H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q7           H        Ph             G3                                       Q9           H        CF.sub.3       G3                                       Q10          H        CF.sub.3       G3                                       Q19          H        CFCFCl         G3                                       Q23          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q32          H        Ph             G3                                       Q41          H        Ph2-Cl         G3                                       Q45          H        Ph2-Me         G3                                       Q50          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q69          H        Ph             G3                                       Q79          H        CF.sub.3       G3                                       Q83          H        CF.sub.3       G3                                       Q96          H        Ph             G3                                       Q124         H        Ph2-Cl         G3                                       Q131         H        Ph2-Me         G3                                       Q132         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q135         H        Ph             G3                                       Q138         H        CF.sub.3       G3                                       Q142         H        CF.sub.3       G3                                       Q157         H        CFCFCl         G3                                       Q159         H        CH.sub.2 Cl    G3                                       Q177         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q180         H        Ph             G3                                       Q184         H        Ph2-Cl         G3                                       Q5           H        Cl             G3                                       Q26          H        Cl             G3                                       Q61          H        Cl             G3                                       Q158         H        Cl             G3                                       Q5           H        Br             G3                                       Q26          H        Br             G3                                       Q61          H        Br             G3                                       Q158         H        Br             G3                                       Q5           H        F              G3                                       Q26          H        F              G3                                       Q61          H        I              G3                                       Q158         H        I              G3                                       Q1           H        Cl             G3                                       Q2           H        Cl             G3                                       Q4           H        Cl             G3                                       Q7           H        Br             G3                                       Q9           H        F              G3                                       Q10          H        I              G3                                       Q19          H        Cl             G3                                       Q23          H        Cl             G3                                       Q32          H        Cl             G3                                       Q41          H        Br             G3                                       Q45          H        Br             G3                                       Q50          H        F              G3                                       Q69          H        Cl             G3                                       Q79          H        F              G3                                       Q83          H        Cl             G3                                       Q96          H        Cl             G3                                       Q124         H        Cl             G3                                       Q131         H        Br             G3                                       Q132         H        Br             G3                                       Q135         H        F              G3                                       Q138         H        Br             G3                                       Q142         H        Cl             G3                                       Q157         H        Cl             G3                                       Q159         H        Cl             G3                                       Q177         H        Br             G3                                       Q180         H        Br             G3                                       Q184         H        Cl             G3                                       Q4           H        NO.sub.2       G3                                       Q5           H        NO.sub.2       G3                                       Q7           H        NO.sub.2       G3                                       Q9           H        NO.sub.2       G3                                       Q23          H        NO.sub.2       G3                                       Q26          H        NO.sub.2       G3                                       Q32          H        NO.sub.2       G3                                       Q61          H        NO.sub.2       G3                                       Q96          H        NO.sub.2       G3                                       Q142         H        NO.sub.2       G3                                       Q158         H        NO.sub.2       G3                                       Q5           H        NH.sub.2       G3                                       Q26          H        NH.sub.2       G3                                       Q61          H        NH.sub.2       G3                                       Q158         H        NH.sub.2       G3                                       Q5           H        NHMe           G3                                       Q26          H        NHMe           G3                                       Q61          H        NHMe           G3                                       Q158         H        NHMe           G3                                       Q5           H        NMe.sub.2      G3                                       Q26          H        NMe.sub.2      G3                                       Q61          H        NMe.sub.2      G3                                       Q158         H        NMe.sub.2      G3                                       Q5           H        NMeEt          G3                                       Q26          H        NMeEt          G3                                       Q61          H        NMeEt          G3                                       Q158         H        NMeEt          G3                                       Q5           H        NHSO.sub.2 Me  G3                                       Q26          H        NHSO.sub.2 Me  G3                                       Q61          H        NHSO.sub.2 Me  G3                                       Q158         H        NHSO.sub.2 Me  G3                                       Q1           H        NH.sub.2       G3                                       Q2           H        NH.sub.2       G3                                       Q4           H        NH.sub.2       G3                                       Q7           H        NHMe           G3                                       Q9           H        NHMe           G3                                       Q10          H        NMe.sub.2      G3                                       Q19          H        NMeEt          G3                                       Q23          H        NMe.sub.2      G3                                       Q32          H        NMeEt          G3                                       Q41          H        NH.sub.2       G3                                       Q45          H        NH.sub.2       G3                                       Q50          H        NHMe           G3                                       Q69          H        NHMe           G3                                       Q79          H        NMe.sub.2      G3                                       Q83          H        NMeEt          G3                                       Q96          H        NHSO.sub.2 Me  G3                                       Q124         H        NMe.sub.2      G3                                       Q131         H        NMeEt          G3                                       Q132         H        NH.sub.2       G3                                       Q135         H        NH.sub.2       G3                                       Q138         H        NHMe           G3                                       Q142         H        NHMe           G3                                       Q157         H        NHSO.sub.2 Me  G3                                       Q159         H        NMe.sub.2      G3                                       Q177         H        NMeEt          G3                                       Q180         H        NH.sub.2       G3                                       Q184         H        NH.sub.2       G3                                       Q4           H        NHCOMe         G3                                       Q5           H        NHCOMe         G3                                       Q7           H        NHCOMe         G3                                       Q9           H        NHCOMe         G3                                       Q23          H        NHCOMe         G3                                       Q26          H        NHCOMe         G3                                       Q32          H        NHCOMe         G3                                       Q61          H        NHCOMe         G3                                       Q96          H        NHCOMe         G3                                       Q142         H        NHCOMe         G3                                       Q158         H        NHCOMe         G3                                       Q5           H        NHCOEt         G3                                       Q26          H        NHCOEt         G3                                       Q61          H        NHCOEt         G3                                       Q158         H        NHCOEt         G3                                       Q5           H        OMe            G3                                       Q26          H        OMe            G3                                       Q61          H        OMe            G3                                       Q158         H        OMe            G3                                       Q5           H        OEt            G3                                       Q26          H        OEt            G3                                       Q61          H        OEt            G3                                       Q158         H        OEt            G3                                       Q5           H        CH.sub.2 OMe   G3                                       Q26          H        CH.sub.2 OMe   G3                                       Q61          H        CH.sub.2 OMe   G3                                       Q158         H        CH.sub.2 OMe   G3                                       Q5           H        SMe            G3                                       Q26          H        SMe            G3                                       Q61          H        SMe            G3                                       Q158         H        SMe            G3                                       Q5           H        SO.sub.2 OMe   G3                                       Q26          H        SO.sub.2 OMe   G3                                       Q61          H        SO.sub.2 OMe   G3                                       Q158         H        SO.sub.2 OMe   G3                                       Q1           H        OMe            G3                                       Q2           H        OMe            G3                                       Q4           H        OEt            G3                                       Q7           H        SO.sub.2 OMe   G3                                       Q9           H        CH.sub.2 OMe   G3                                       Q10          H        SMe            G3                                       Q19          H        SO.sub.2 OMe   G3                                       Q23          H        OMe            G3                                       Q32          H        OEt            G3                                       Q41          H        SO.sub.2 OMe   G3                                       Q45          H        CH.sub.2 OMe   G3                                       Q50          H        SMe            G3                                       Q69          H        SO.sub.2 OMe   G3                                       Q79          H        OMe            G3                                       Q83          H        OEt            G3                                       Q96          H        CH.sub.2 OMe   G3                                       Q124         H        SMe            G3                                       Q131         H        OMe            G3                                       Q132         H        OEt            G3                                       Q135         H        CH.sub.2 OMe   G3                                       Q138         H        SMe            G3                                       Q142         H        SO.sub.2 OMe   G3                                       Q157         H        OMe            G3                                       Q159         H        OEt            G3                                       Q177         H        SO.sub.2 OMe   G3                                       Q180         H        OMe            G3                                       Q184         H        OEt            G3                                       Q4           H        SO.sub.2 Me    G3                                       Q5           H        SO.sub.2 Me    G3                                       Q7           H        SO.sub.2 Me    G3                                       Q9           H        SO.sub.2 Me    G3                                       Q23          H        SO.sub.2 Me    G3                                       Q26          H        SO.sub.2 Me    G3                                       Q32          H        SO.sub.2 Me    G3                                       Q61          H        SO.sub.2 Me    G3                                       Q96          H        SO.sub.2 Me    G3                                       Q142         H        SO.sub.2 Me    G3                                       Q158         H        SO.sub.2 Me    G3                                       Q188         H        SO.sub.2 Me    Gb                                       Q189         H        SO.sub. 2 Me   Gb                                       Q5           H        SO.sub.2 Ph    G3                                       Q26          H        SO.sub.2 Ph    G3                                       Q61          H        SO.sub.2 Ph    G3                                       Q158         H        SO.sub.2 Ph    G3                                       Q5           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q26          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q61          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q158         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q5           H        SO.sub.2 NHMe  G3                                       Q26          H        SO.sub.2 NHMe  G3                                       Q61          H        SO.sub.2 NHMe  G3                                       Q158         H        SO.sub.2 NHMe  G3                                       Q5           H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q26          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q61          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q158         H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q1           H        SO.sub.2 Me    G3                                       Q2           H        SO.sub.2 Me    G3                                       Q4           H        SO.sub.2 Ph    G3                                       Q7           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q9           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q10          H        SO.sub.2 Ph    G3                                       Q19          H        SO.sub.2 Me    G3                                       Q23          H        SO.sub.2 Ph    G3                                       Q32          H        SO.sub.2 NHMe  G3                                       Q41          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q45          H        SO.sub.2 Me    G3                                       Q50          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q69          H        SO.sub.2 Me    G3                                       Q79          H        SO.sub.2 Ph    G3                                       Q83          H        SO.sub.2 Me    G3                                       Q96          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q124         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q131         H        SO.sub.2 Me    G3                                       Q132         H        SO.sub.2 Me    G3                                       Q135         H        SO.sub.2 NHMe  G3                                       Q138         H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q142         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q157         H        SO.sub.2 Me    G3                                       Q159         H        SO.sub.2 Me    G3                                       Q177         H        SO.sub.2 NHMe  G3                                       Q180         H        SO.sub.2 NHMe.sub.2                                                                          G3                                       Q184         H        SO.sub.2 Me    G3                                       Q1           Me       COOMe          G3                                       Q2           Me       COOMe          G3                                       Q4           Me       COOMe          G3                                       Q5           Me       COOMe          G3                                       Q7           Me       COOMe          G3                                       Q9           Me       COOMe          G3                                       Q10          Me       COOMe          G3                                       Q19          Me       COOMe          G3                                       Q23          Me       COOMe          G3                                       Q26          Me       COOMe          G3                                       Q32          Me       COOMe          G3                                       Q41          Me       COOMe          G3                                       Q45          Me       COOMe          G3                                       Q50          Me       COOMe          G3                                       Q61          Me       COOMe          G3                                       Q69          Me       COOMe          G3                                       Q79          Me       COOMe          G3                                       Q83          Me       COOMe          G3                                       Q96          Me       COOMe          G3                                       Q124         Me       COOMe          G3                                       Q131         Me       COOMe          G3                                       Q132         Me       COOMe          G3                                       Q135         Me       COOMe          G3                                       Q138         Me       COOMe          G3                                       Q142         Me       COOMe          G3                                       Q157         Me       COOMe          G3                                       Q158         Me       COOMe          G3                                       Q159         Me       COOMe          G3                                       Q177         Me       COOMe          G3                                       Q180         Me       COOMe          G3                                       Q184         Me       COOMe          G3                                       Q1           Me       COOEt          G3                                       Q2           Me       COOEt          G3                                       Q4           Me       COOEt          G3                                       Q5           Me       COOEt          G3                                       Q7           Me       COOEt          G3                                       Q9           Me       COOEt          G3                                       Q10          Me       COOEt          G3                                       Q19          Me       COOEt          G3                                       Q23          Me       COOEt          G3                                       Q26          Me       COOEt          G3                                       Q32          Me       COOEt          G3                                       Q41          Me       COOEt          G3                                       Q45          Me       COOEt          G3                                       Q50          Me       COOEt          G3                                       Q61          H        COOEt          G3                                       Q69          Me       COOEt          G3                                       Q79          Me       COOEt          G3                                       Q83          Me       COOEt          G3                                       Q96          Me       COOEt          G3                                       Q124         Me       COOEt          G3                                       Q131         Me       COOEt          G3                                       Q132         Me       COOEt          G3                                       Q135         Me       COOEt          G3                                       Q138         Me       COOEt          G3                                       Q142         Me       COOEt          G3                                       Q157         Me       COOEt          G3                                       Q158         Me       COOEt          G3                                       Q159         Me       COOEt          G3                                       Q177         Me       COOEt          G3                                       Q180         Me       COOEt          G3                                       Q184         Me       COOEt          G3                                       Q158         Me       COOEt          G3                                       Q5           Me       COOPri         G3                                       Q26          Me       COOPri         G3                                       Q61          Me       COOPri         G3                                       Q158         Me       COOPri         G3                                       Q5           Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q61          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q158         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q26          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q61          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           Me       COOCH.sub.2 C CH                                                                             G3                                       Q26          Me       COOCH.sub.2 C CH                                                                             G3                                       Q61          Me       COOCH.sub.2 C CH                                                                             G3                                       Q158         Me       COOCH.sub.2 C CH                                                                             G3                                       Q5           Me       CONHMe         G3                                       Q26          Me       CONHMe         G3                                       Q61          Me       CONHMe         G3                                       Q158         Me       CONHMe         G3                                       Q5           Me       CONMe.sub.2    G3                                       Q26          Me       CONMe.sub.2    G3                                       Q61          Me       CONMe.sub.2    G3                                       Q158         Me       CONMe.sub.2    G3                                       Q1           Me       COOPri         G3                                       Q2           Me       COOPri         G3                                       Q4           Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q7           Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q9           Me       COOCH.sub.2 C CH                                                                             G3                                       Q10          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q19          Me       COOPri         G3                                       Q23          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q32          Me       CONMe.sub.2    G3                                       Q41          Me       COOPri         G3                                       Q45          Me       CONHMe         G3                                       Q50          Me       CONMe.sub.2    G3                                       Q69          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q79          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q83          Me       COOPri         G3                                       Q96          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q124         Me       COOPri         G3                                       Q131         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q132         Me       CONHMe         G3                                       Q135         Me       CONMe.sub.2    G3                                       Q138         Me       COOCH.sub.2 C CH                                                                             G3                                       Q142         Me       COOPri         G3                                       Q157         Me       COOPri         G3                                       Q159         Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q177         Me       COOCH.sub.2 C CH                                                                             G3                                       Q180         Me       COOPri         G3                                       Q184         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Me       COMe           G3                                       Q26          Me       COMe           G3                                       Q61          Me       COMe           G3                                       Q158         Me       COMe           G3                                       Q5           Me       COEt           G3                                       Q26          Me       COEt           G3                                       Q61          Me       COEt           G3                                       Q158         Me       COEt           G3                                       Q5           Me       COPri          G3                                       Q26          Me       COPri          G3                                       Q61          Me       COPri          G3                                       Q158         Me       COPri          G3                                       Q5           Me       CN             G3                                       Q26          Me       CN             G3                                       Q61          Me       CN             G3                                       Q158         Me       CN             G3                                       Q5           Me       H              G3                                       Q26          Me       H              G3                                       Q61          Me       H              G3                                       Q158         Me       H              G3                                       Q5           Me       Me             G3                                       Q26          Me       Me             G3                                       Q61          Me       Me             G3                                       Q158         Me       Me             G3                                       Q5           Me       Et             G3                                       Q26          Me       Et             G3                                       Q61          Me       Et             G3                                       Q158         Me       Et             G3                                       Q5           Me       Pri            G3                                       Q26          Me       Pri            G3                                       Q61          Me       CHCH.sub.2     G3                                       Q158         Me       CHCH.sub.2     G3                                       Q5           Me       CHCHMe         G3                                       Q26          Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q61          Me       CHCHMe         G3                                       Q158         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q1           Me       COMe           G3                                       Q2           Me       COEt           G3                                       Q4           Me       CHCHMe         G3                                       Q7           Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q9           Me       CN             G3                                       Q10          Me       H              G3                                       Q19          Me       Me             G3                                       Q23          Me       COMe           G3                                       Q32          Me       COEt           G3                                       Q41          Me       H              G3                                       Q45          Me       Me             G3                                       Q50          Me       COPri          G3                                       Q69          Me       CN             G3                                       Q79          Me       Et             G3                                       Q83          Me       Pri            G3                                       Q96          Me       COMe           G3                                       Q124         Me       COEt           G3                                       Q131         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q132         Me       Me             G3                                       Q135         Me       COPr-i         G3                                       Q138         Me       CN             G3                                       Q142         Me       Et             G3                                       Q157         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q159         Me       COMe           G3                                       Q177         Me       COEt           G3                                       Q180         Me       CHCHMe         G3                                       Q184         Me       COMe           G3                                       Q5           Me       CH.sub.2 Cl    G3                                       Q26          Me       CH.sub. 2 Cl   G3                                       Q5           Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q61          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q5           Me       CF.sub.3       G3                                       Q26          Me       CF.sub.3       G3                                       Q61          Me       CF.sub.3       G3                                       Q158         Me       CF.sub.3       G3                                       Q5           Me       CFCFCl         G3                                       Q26          Me       CFCFCl         G3                                       Q61          Me       CH.sub.2 Ph    G3                                       Q158         Me       CH.sub.2 Ph    G3                                       Q5           Me       Ph             G3                                       Q26          Me       Ph             G3                                       Q61          Me       Ph             G3                                       Q158         Me       Ph             G3                                       Q5           Me       Ph2-Cl         G3                                       Q26          Me       Ph2-Cl         G3                                       Q61          Me       Ph2-Me         G3                                       Q158         Me       Ph2-Me         G3                                       Q5           Me       Cl             G3                                       Q26          Me       Cl             G3                                       Q61          Me       Cl             G3                                       Q158         Me       Cl             G3                                       Q5           Me       Br             G3                                       Q26          Me       Br             G3                                       Q61          Me       Br             G3                                       Q158         Me       Br             G3                                       Q5           Me       F              G3                                       Q26          Me       F              G3                                       Q61          Me       I              G3                                       Q158         Me       I              G3                                       Q1           Me       Ph             G3                                       Q2           Me       Cl             G3                                       Q4           Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q7           Me       Ph             G3                                       Q9           Me       Ph             G3                                       Q10          Me       Cl             G3                                       Q19          Me       Cl             G3                                       Q23          Me       Br             G3                                       Q32          Me       CH.sub. 2 Cl   G3                                       Q41          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q45          Me       CF.sub.3       G3                                       Q50          Me       Cl             G3                                       Q69          Me       Cl             G3                                       Q79          Me       Br             G3                                       Q83          Me       Ph             G3                                       Q96          Me       CF.sub.3       G3                                       Q124         Me       CF.sub.3       G3                                       Q131         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q132         Me       Ph             G3                                       Q135         Me       Br             G3                                       Q138         Me       Ph             G3                                       Q142         Me       Ph             G3                                       Q157         Me       Cl             G3                                       Q159         Me       Br             G3                                       Q177         Me       CF.sub.3       G3                                       Q180         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q184         Me       Ph             G3                                       Q5           Me       NO.sub.2       G3                                       Q26          Me       NO.sub.2       G3                                       Q61          Me       NO.sub.2       G3                                       Q158         Me       NO.sub.2       G3                                       Q5           Me       NH.sub.2       G3                                       Q26          Me       NH.sub.2       G3                                       Q61          Me       NH.sub.2       G3                                       Q158         Me       NH.sub.2       G3                                       Q5           Me       NHMe           G3                                       Q26          Me       NHMe           G3                                       Q61          Me       NHMe           G3                                       Q158         Me       NHMe           G3                                       Q5           Me       NMe.sub.2      G3                                       Q26          Me       NMe.sub.2      G3                                       Q61          Me       NMe.sub.2      G3                                       Q158         Me       NMe.sub.2      G3                                       Q5           Me       NMeEt          G3                                       Q26          Me       NMeEt          G3                                       Q5           Me       NHCOMe         G3                                       Q26          Me       NHCOMe         G3                                       Q61          Me       NHCOMe         G3                                       Q158         Me       NHCOMe         G3                                       Q5           Me       NHCOEt         G3                                       Q26          Me       NHCOEt         G3                                       Q61          Me       NHSO.sub.2 Me  G3                                       Q158         Me       NHSO.sub.2 Me  G3                                       Q5           Me       OMe            G3                                       Q26          Me       OMe            G3                                       Q61          Me       OMe            G3                                       Q158         Me       OMe            G3                                       Q5           Me       OEt            G3                                       Q26          Me       OEt            G3                                       Q61          Me       CH.sub.2 OMe   G3                                       Q158         Me       CH.sub.2 OMe   G3                                       Q1           Me       NO.sub.2       G3                                       Q2           Me       NHCOMe         G3                                       Q4           Me       NHCOEt         G3                                       Q7           Me       NHMe           G3                                       Q9           Me       NO.sub.2       G3                                       Q10          Me       NH.sub.2       G3                                       Q19          Me       NHCOMe         G3                                       Q23          Me       OMe            G3                                       Q32          Me       NHCOMe         G3                                       Q41          Me       NHCOEt         G3                                       Q45          Me       CH.sub.2 OMe   G3                                       Q50          Me       OMe            G3                                       Q69          Me       OEt            G3                                       Q79          Me       NO.sub.2       G3                                       Q83          Me       NH.sub.2       G3                                       Q96          Me       NMe.sub.2      G3                                       Q124         Me       NMeEt          G3                                       Q131         Me       NHCOMe         G3                                       Q132         Me       NHCOEt         G3                                       Q135         Me       NO.sub.2       G3                                       Q138         Me       OMe            G3                                       Q142         Me       OEt            G3                                       Q157         Me       NO.sub.2       G3                                       Q159         Me       NH.sub.2       G3                                       Q177         Me       OMe            G3                                       Q180         Me       NHCOMe         G3                                       Q184         Me       NO.sub.2       G3                                       Q26          Me       SMe            G3                                       Q61          Me       SMe            G3                                       Q5           Me       SO.sub.2 Me    G3                                       Q26          Me       SO.sub.2 Me    G3                                       Q61          Me       SO.sub.2 Me    G3                                       Q158         Me       SO.sub.2 Me    G3                                       Q5           Me       SO.sub.2 Ph    G3                                       Q26          Me       SO.sub.2 Ph    G3                                       Q61          Me       SO.sub.2 Ph    G3                                       Q158         Me       SO.sub.2 Ph    G3                                       Q5           Me       SO.sub.2 OMe   G3                                       Q26          Me       SO.sub.2 OMe   G3                                       Q61          Me       SO.sub.2 NH.sub.2                                                                            G3                                       Q158         Me       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Me       SO.sub.2 NHMe  G3                                       Q26          Me       SO.sub.2 NHMe  G3                                       Q61          Me       SO.sub.2 NHMe  G3                                       Q158         Me       SO.sub.2 NHMe  G3                                       Q5           Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q26          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q61          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q158         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q1           Me       SO.sub.2 Ph    G3                                       Q2           Me       SO.sub.2 OMe   G3                                       Q4           Me       SO.sub.2 NHMe  G3                                       Q7           Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q9           Me       SO.sub.2 Me    G3                                       Q10          Me       SO.sub.2 Me    G3                                       Q19          Me       SMe            G3                                       Q23          Me       SO.sub.2 Me    G3                                       Q32          Me       SO.sub.2 OMe   G3                                       Q41          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q45          Me       SO.sub.2 NHMe  G3                                       Q50          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q69          Me       SO.sub.2 Me    G3                                       Q79          Me       SO.sub.2 Me    G3                                       Q83          Me       SO.sub.2 Ph    G3                                       Q96          Me       SO.sub.2 OMe   G3                                       Q124         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q131         Me       SO.sub.2 NHMe  G3                                       Q132         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q135         Me       SO.sub.2 Ph    G3                                       Q138         Me       SO.sub.2 Ph    G3                                       Q142         Me       SO.sub.2 Me    G3                                       Q157         Me       SO.sub.2 Me    G3                                       Q159         Me       SO.sub.2 NHMe  G3                                       Q177         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q180         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q184         Me       SO.sub.2 Me.sub.2                                                                            G3                                       Q5           Et       COOMe          G3                                       Q26          Et       COOMe          G3                                       Q61          Et       COOMe          G3                                       Q142         Et       COOMe          G3                                       Q158         Et       COOMe          G3                                       Q159         Et       COOMe          G3                                       Q4           Et       COOEt          G3                                       Q5           Et       COOEt          G3                                       Q9           Et       COOEt          G3                                       Q26          Et       COOEt          G3                                       Q32          Et       COOEt          G3                                       Q61          Et       COOEt          G3                                       Q69          Et       COOEt          G3                                       Q96          Et       COOEt          G3                                       Q158         Et       COOEt          G3                                       Q61          Et       COOPri         G3                                       Q158         Et       COOPri         G3                                       Q5           Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           Et       COOCH.sub.2 C CH                                                                             G3                                       Q26          Et       COOCH.sub.2 C CH                                                                             G3                                       Q5           Et       CONHMe         G3                                       Q26          Et       CONMe.sub.2    G3                                       Q1           Et       COOPri         G3                                       Q4           Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q69          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q79          Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q83          Et       COOPri         G3                                       Q96          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q131         Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q157         Et       COOPri         G3                                       Q159         Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q184         Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Et       COMe           G3                                       Q26          Et       COMe           G3                                       Q158         Et       COEt           G3                                       Q5           Et       COPri          G3                                       Q26          Et       CN             G3                                       Q61          Et       H              G3                                       Q26          Et       Me             G3                                       Q158         Et       Et             G3                                       Q5           Et       Pri            G3                                       Q1           Et       COMe           G3                                       Q2           Et       COEt           G3                                       Q9           Et       CN             G3                                       Q23          Et       COMe           G3                                       Q96          Et       COMe           G3                                       Q124         Et       COEt           G3                                       Q135         Et       COPri          G3                                       Q138         Et       CN             G3                                       Q5           Et       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          Et       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Et       CF.sub.3       G3                                       Q5           Et       Ph             G3                                       Q26          Et       Ph             G3                                       Q158         Et       Ph2-Me         G3                                       Q26          Et       Cl             G3                                       Q61          Et       Cl             G3                                       Q5           Et       Br             G3                                       Q1           Et       Ph             G3                                       Q2           Et       Cl             G3                                       Q9           Et       Ph             G3                                       Q5           Et       NO.sub.2       G3                                       Q5           Et       NH.sub.2       G3                                       Q5           Et       NHMe           G3                                       Q26          Et       NMe.sub.2      G3                                       Q61          Et       NHCOMe         G3                                       Q158         Et       NHSO.sub.2 Me  G3                                       Q2           Et       NHCOMe         G3                                       Q23          Et       OMe            G3                                       Q32          Et       NHCOMe         G3                                       Q96          Et       NMe.sub.2      G3                                       Q26          Et       SO.sub.2 Me    G3                                       Q61          Et       SO.sub.2 Me    G3                                       Q5           Et       SO.sub.2 Ph    G3                                       Q26          Et       SO.sub.2 OMe   G3                                       Q61          Et       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Et       SO.sub.2 NHMe  G3                                       Q26          Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q4           Et       SO.sub.2 NHMe  G3                                       Q7           Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q9           Et       SO.sub.2 Me    G3                                       Q142         Et       SO.sub.2 Me    G3                                       Q159         Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           Cl       COOMe          G3                                       Q26          Cl       COOMe          G3                                       Q61          Cl       COOMe          G3                                       Q5           Cl       COOEt          G3                                       Q26          Cl       COOEt          G3                                       Q61          Cl       COOEt          G3                                       Q96          Cl       COOEt          G3                                       Q158         Cl       COOEt          G3                                       Q61          Cl       COOPri         G3                                       Q5           Cl       COMe           G3                                       Q158         Cl       COEt           G3                                       Q5           Cl       COPri          G3                                       Q26          Cl       CN             G3                                       Q61          Cl       H              G3                                       Q26          Cl       Me             G3                                       Q158         Cl       Et             G3                                       Q5           Cl       Pri            G3                                       Q1           Cl       COMe           G3                                       Q26          Cl       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Cl       CF.sub.3       G3                                       Q5           Cl       Ph             G3                                       Q26          Cl       Cl             G3                                       Q5           Cl       Br             G3                                       Q2           Cl       Cl             G3                                       Q9           Cl       Ph             G3                                       Q5           Cl       NO.sub.2       G3                                       Q5           Cl       NH.sub.2       G3                                       Q5           Cl       NHMe           G3                                       Q26          Cl       NMe.sub.2      G3                                       Q61          Cl       NHCOMe         G3                                       Q158         Cl       NHSO.sub.2 Me  G3                                       Q2           Cl       NHCOMe         G3                                       Q26          Cl       SO.sub.2 Me    G3                                       Q61          Cl       SO.sub.2 Me    G3                                       Q5           Cl       SO.sub.2 Ph    G3                                       Q61          Cl       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Cl       SO.sub.2 NHMe  G3                                       Q26          Cl       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           Br       COOMe          G3                                       Q26          Br       COOMe          G3                                       Q61          Br       COOMe          G3                                       Q5           Br       COOEt          G3                                       Q26          Br       COOEt          G3                                       Q61          Br       COOEt          G3                                       Q61          Br       COOPri         G3                                       Q5           Br       COMe           G3                                       Q158         Br       COEt           G3                                       Q26          Br       CN             G3                                       Q26          Br       Me             G3                                       Q158         Br       Et             G3                                       Q26          Br       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Br       CF.sub.3       G3                                       Q5           Br       Ph             G3                                       Q26          Br       Cl             G3                                       Q5           Br       Br             G3                                       Q5           Br       NO.sub.2       G3                                       Q5           Br       NH.sub.2       G3                                       Q26          Br       NMe.sub.2      G3                                       Q61          Br       NHCOMe         G3                                       Q61          Br       SO.sub.2 Me    G3                                       Q5           Br       SO.sub.2 Ph    G3                                       Q61          Br       SO.sub.2 NH.sub.2                                                                            G3                                       Q26          Br       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           SMe      COOMe          G3                                       Q26          SMe      COOMe          G3                                       Q61          SMe      COOMe          G3                                       Q5           SMe      COOEt          G3                                       Q26          SMe      COOEt          G3                                       Q61          SMe      COOEt          G3                                       Q61          SMe      COOPri         G3                                       Q5           SMe      COMe           G3                                       Q158         SMe      COEt           G3                                       Q26          SMe      CN             G3                                       Q26          SMe      Me             G3                                       Q158         SMe      Et             G3                                       Q26          SMe      CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         SMe      CF.sub.3       G3                                       Q5           SMe      Ph             G3                                       Q26          SMe      Cl             G3                                       Q5           SMe      Br             G3                                       Q5           SMe      NO.sub.2       G3                                       Q5           SMe      NH.sub.2       G3                                       Q26          SMe      NMe.sub.2      G3                                       Q61          SMe      NHCOMe         G3                                       Q61          SMe      SO.sub.2 Me    G3                                       Q5           SMe      SO.sub.2 Ph    G3                                       Q61          SMe      SO.sub.2 NH.sub.2                                                                            G3                                       Q26          SMe      SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           SO.sub.2 Me                                                                            COOMe          G3                                       Q26          SO.sub.2 Me                                                                            COOMe          G3                                       Q61          SO.sub.2 Me                                                                            COOMe          G3                                       Q5           SO.sub.2 Me                                                                            COOEt          G3                                       Q26          SO.sub.2 Me                                                                            COOEt          G3                                       Q61          SO.sub.2 Me                                                                            COOEt          G3                                       Q96          SO.sub.2 Me                                                                            COOEt          G3                                       Q158         SO.sub.2 Me                                                                            COOEt          G3                                       Q61          SO.sub.2 Me                                                                            COOPr i        G3                                       Q5           SO.sub.2 Me                                                                            COMe           G3                                       Q158         SO.sub.2 Me                                                                            COEt           G3                                       Q5           SO.sub.2 Me                                                                            COPri          G3                                       Q26          SO.sub.2 Me                                                                            CN             G3                                       Q61          SO.sub.2 Me                                                                            H              G3                                       Q26          SO.sub.2 Me                                                                            Me             G3                                       Q158         SO.sub.2 Me                                                                            Et             G3                                       Q5           SO.sub.2 Me                                                                            Pri            G3                                       Q1           SO.sub.2 Me                                                                            COMe           G3                                       Q26          SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         SO.sub.2 Me                                                                            CF.sub.3       G3                                       Q5           SO.sub.2 Me                                                                            Ph             G3                                       Q26          SO.sub.2 Me                                                                            Cl             G3                                       Q5           SO.sub.2 Me                                                                            Br             G3                                       Q2           SO.sub.2 Me                                                                            Cl             G3                                       Q9           SO.sub.2 Me                                                                            Ph             G3                                       Q5           SO.sub.2 Me                                                                            NO.sub.2       G3                                       Q5           SO.sub.2 Me                                                                            NH.sub.2       G3                                       Q5           SO.sub.2 Me                                                                            NHMe           G3                                       Q26          SO.sub.2 Me                                                                            NMe.sub.2      G3                                       Q61          SO.sub.2 Me                                                                            NHCOMe         G3                                       Q158         SO.sub.2 Me                                                                            NHSO.sub.2 Me  G3                                       Q2           SO.sub.2 Me                                                                            NHCOMe         G3                                       Q26          SO.sub.2 Me                                                                            SO.sub.2 Me    G3                                       Q61          SO.sub.2 Me                                                                            SO.sub.2 Me    G3                                       Q5           SO.sub.2 Me                                                                            SO.sub.2 Ph    G3                                       Q61          SO.sub.2 Me                                                                            SO.sub.2 NH.sub.2                                                                            G3                                       Q5           SO.sub.2 Me                                                                            SO.sub.2 NHMe  G3                                       Q26          SO.sub.2 Me                                                                            SO.sub.2 NMe.sub. 2                                                                          G3                                       Q5           Ph       COOMe          G3                                       Q26          Ph       COOMe          G3                                       Q61          Ph       COOMe          G3                                       Q5           Ph       COOEt          G3                                       Q26          Ph       COOEt          G3                                       Q61          Ph       COOEt          G3                                       Q61          Ph       COOPri         G3                                       Q5           Ph       COMe           G3                                       Q158         Ph       COEt           G3                                       Q26          Ph       CN             G3                                       Q26          Ph       Me             G3                                       Q158         Ph       Et             G3                                       Q26          Ph       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Ph       CF.sub.3       G3                                       Q5           Ph       Ph             G3                                       Q26          Ph       Cl             G3                                       Q5           Ph       Br             G3                                       Q5           Ph       NO.sub.2       G3                                       Q5           Ph       NH.sub.2       G3                                       Q26          Ph       NMe.sub.2      G3                                       Q61          Ph       NHCOMe         G3                                       Q61          Ph       SO.sub.2 Me    G3                                       Q5           Ph       SO.sub.2 Ph    G3                                       Q61          Ph       SO.sub.2 NH.sub.2                                                                            G3                                       Q26          Ph       SO.sub.2 NMe.sub.2                                                                           G3                                       Q201         H        COOMe          Ga                                       CH.sub.2 - Q201                                                                            H        COOMe          Gb                                       CHMe - Q201  H        COOMe          Gb                                       Q202         H        COOMe          Gb                                       CH.sub.2 - Q202                                                                            H        COOMe          Gb                                       Q203         H        COOMe          Gb                                       Q204         H        COOMe          Gb                                       Q205         H        COOMe          Gb                                       CH.sub.2 - Q205                                                                            H        COOMe          Gc                                       Q206         H        COOMe          G.sub.3                                  Q207         H        COOMe          Gc                                       Q208         H        COOMe          G.sub.3                                  Q209         H        COOMe          Gc                                       CH.sub.2 - Q209                                                                            H        COOMe          Gc                                       Q210         H        COOMe          Gc                                       CH.sub.2 - Q210                                                                            H        COOMe          G.sub.3                                  Q211         H        COOMe          G.sub.3                                  Q212         H        COOMe          Gc                                       Q213         H        COOMe          Gc                                       Q214         H        COOMe          Gc                                       Q215         H        COOMe          G.sub.1                                  Q216         H        COOMe          Gc                                       Q217         H        COOMe          Gc                                       Q218         H        COOMe          G.sub.3                                  Q219         H        COOMe          Gc                                       Q220         H        COOMe          Gc                                       Q221         H        COOMe          G.sub.2                                  Q222         H        COOMe          Gb                                       CH.sub.2 - Q222                                                                            H        COOMe          Gc                                       Q223         H        COOMe          Gc                                       Q224         H        COOMe          G.sub.3                                  Q225         H        COOMe          Gb                                       CH.sub.2 - Q225                                                                            H        COOMe          Gc                                       Q226         H        COOMe          G.sub.3                                  Q227         H        COOMe          Gc                                       Q228         H        COOMe          Gc                                       Q229         H        COOMe          Gb                                       CH.sub.2 - Q229                                                                            H        COOMe          Gc                                       Q230         H        COOMe          Gc                                       Q231         H        COOMe          Gc                                       Q232         H        COOMe          G.sub.3                                  Q233         H        COOMe          Gc                                       Q234         H        COOMe          Gc                                       Q235         H        COOMe          Gc                                       Q236         H        COOMe          G.sub.3                                  Q237         H        COOMe          Gc                                       Q238         H        COOMe          Gc                                       Q239         H        COOMe          G.sub.2                                  Q240         H        COOMe          Gc                                       Q241         H        COOMe          Gc                                       Q242         H        COOMe          Gc                                       Q243         H        COOMe          G.sub.1                                  Q244         H        COOMe          Gc                                       Q245         H        COOMe          Gc                                       Q246         H        COOMe          Gb                                       CH.sub.2 - Q246                                                                            H        COOMe          Gc                                       Q247         H        COOMe          G.sub. 3                                 Q248         H        COOMe          Gc                                       Q249         H        COOMe          Gc                                       Q250         H        COOMe          Gc                                       CH.sub.2 - Q250                                                                            H        COOMe          G.sub.3                                  Q251         H        COOMe          Gc                                       Q252         H        COOMe          Gc                                       Q253         H        COOMe          Gc                                       Q254         H        COOMe          G.sub.1                                  Q255         H        COOMe          Gc                                       Q256         H        COOMe          Gc                                       Q257         H        COOMe          G.sub.3                                  Q258         H        COOMe          Gc                                       Q259         H        COOMe          Gc                                       CH.sub.2 - Q259                                                                            H        COOMe          Gc                                       Q260         H        COOMe          Gc                                       CH.sub.2 - Q260                                                                            H        COOMe          Gc                                       Q261         H        COOMe          G.sub.1                                  Q262         H        COOMe          Gc                                       Q263         H        COOMe          Gc                                       Q264         H        COOMe          G.sub.2                                  Q201         H        COOEt          Ga                                       CH.sub.2 - Q201                                                                            H        COOEt          Gb                                       CHMe - Q201  H        COOEt          Gb                                       Q202         H        COOEt          Gb                                       CH.sub.2 - Q202                                                                            H        COOEt          Gb                                       Q203         H        COOEt          Gb                                       Q204         H        COOEt          Gb                                       Q205         H        COOEt          Gb                                       CH.sub.2 - Q205                                                                            H        COOEt          Gc                                       Q206         H        COOEt          G.sub.3                                  Q207         H        COOEt          Gc                                       Q208         H        COOEt          G.sub.3                                  Q209         H        COOEt          Gc                                       CH.sub.2 - Q209                                                                            H        COOEt          Gc                                       Q210         H        COOEt          Gc                                       CH.sub.2 - 210                                                                             H        COOEt          G.sub.3                                  Q211         H        COOEt          Gc                                       Q212         H        COOEt          Gc                                       Q213         H        COOEt          Gc                                       Q214         H        COOEt          G.sub.1                                  Q215         H        COOEt          Gc                                       Q216         H        COOEt          Gc                                       Q217         H        COOEt          G.sub.2                                  Q218         H        COOEt          Gc                                       Q219         H        COOEt          Gc                                       Q220         H        COOEt          G.sub.3                                  Q221         H        COOEt          Gc                                       Q222         H        COOEt          Gb                                       CH.sub.2 - Q222                                                                            H        COOEt          Gc                                       Q223         H        COOEt          Gc                                       Q224         H        COOEt          Gc                                       Q225         H        COOEt          Gb                                       CH.sub.2 - Q225                                                                            H        COOEt          Gc                                       Q226         H        COOEt          G.sub.3                                  Q227         H        COOEt          Gc                                       Q228         H        COOEt          Gc                                       Q229         H        COOEt          Gb                                       CH.sub.2 - Q229                                                                            H        COOEt          Gc                                       Q230         H        COOEt          Gc                                       Q231         H        COOEt          Gc                                       Q232         H        COOEt          G.sub.3                                  Q233         H        COOEt          Gc                                       Q234         H        COOEt          Gc                                       CH.sub.2 - Q234                                                                            H        COOEt          Gc                                       Q235         H        COOEt          Gc                                       Q236         H        COOEt          G.sub.3                                  Q237         H        COOEt          Gc                                       Q238         H        COOEt          Gc                                       Q239         H        COOEt          Gc                                       Q240         H        COOEt          G.sub.1                                  Q241         H        COOEt          Gc                                       Q242         H        COOEt          Gc                                       Q243         H        COOEt          Gc                                       Q244         H        COOEt          G.sub.2                                  Q245         H        COOEt          Gc                                       Q246         H        COOEt          Gb                                       CH.sub.2 - Q246                                                                            H        COOEt          Gc                                       Q247         H        COOEt          Gc                                       Q248         H        COOEt          Gc                                       Q249         H        COOEt          G.sub.3                                  Q250         H        COOEt          Gc                                       CH.sub.2  - Q250                                                                           H        COOEt          Gc                                       Q251         H        COOEt          Gc                                       Q252         H        COOEt          G.sub.3                                  Q253         H        COOEt          Gc                                       Q254         H        COOEt          Gc                                       Q255         H        COOEt          Gc                                       Q256         H        COOEt          Gc                                       Q257         H        COOEt          Gc                                       Q258         H        COOEt          G.sub.1                                  Q259         H        COOEt          Gc                                       CH.sub.2 - Q259                                                                            H        COOEt          Gc                                       Q260         H        COOEt          Gc                                       CH.sub.2 - Q260                                                                            H        COOEt          Gc                                       Q261         H        COOEt          G.sub.3                                  Q262         H        COOEt          Gc                                       Q263         H        COOEt          Gc                                       Q264         H        COOEt          G.sub.3                                  Q201         H        COOH           Gc                                       Q202         H        COOH           Gc                                       Q222         H        COOH           Gc                                       Q225         H        COOH           G.sub.3                                  Q229         H        COOH           Gc                                       Q246         H        COOH           G.sub.3                                  Q201         H        COOPri         Gc                                       Q202         H        COOPri         G.sub.3                                  Q205         H        COOPri         Gc                                       Q209         H        COOPri         Gc                                       Q222         H        COOPri         Gc                                       Q225         H        COOPri         Gc                                       Q229         H        COOPri         G.sub.3                                  Q246         H        COOPri         Gc                                       Q201         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q202         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q205         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q209         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q222         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q225         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q229         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q246         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.1                                  Q201         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q202         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q205         H        COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q209         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q222         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q225         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q229         H        COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q246         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         H        COOCH.sub.2 CCH                                                                              Gc                                       Q202         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q205         H        COOCH.sub.2 CCH                                                                              Gc                                       Q209         H        COOCH.sub.2 CCH                                                                              Gc                                       Q222         H        COOCH.sub.2 CCH                                                                              Gc                                       Q225         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q229         H        COOCH.sub.2 CCH                                                                              Gc                                       Q246         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         H        CONHMe         Gc                                       Q202         H        CONHMe         G.sub.3                                  Q205         H        CONHMe         Gc                                       Q209         H        CONHMe         Gc                                       Q222         H        CONHMe         G.sub.3                                  Q225         H        CONHMe         Gc                                       Q229         H        CONHMe         Gc                                       Q246         H        CONHMe         G.sub.3                                  Q201         H        CONMe.sub.2    Gc                                       Q202         H        CONMe.sub.2    G.sub.3                                  Q205         H        CONMe.sub.2    Gc                                       Q209         H        CONMe.sub.2    Gc                                       Q222         H        CONMe.sub.2    Gc                                       Q225         H        CONMe.sub.2    G.sub.3                                  Q229         H        CONMe.sub.2    Gc                                       Q246         H        CONMe.sub.2    G.sub.2                                  Q201         H        COMe           Gc                                       CH.sub.2 - Q201                                                                            H        COMe           G.sub.3                                  Q202         H        COMe           G.sub.3                                  Q205         H        COMe           Gc                                       Q207         H        COMe           G.sub.3                                  Q222         H        COMe           Gc                                       Q225         H        COMe           Gc                                       Q229         H        COMe           Gc                                       Q230         H        COMe           G.sub.2                                  Q231         H        COMe           G.sub.3                                  Q237         H        COMe           Gc                                       Q246         H        COMe           Gc                                       Q247         H        COMe           G.sub.3                                  Q250         H        COMe           Gc                                       Q259         H        COMe           Gc                                       Q260         H        COMe           Gc                                       Q263         H        COMe           G.sub.3                                  Q201         H        COEt           Gc                                       Q202         H        COEt           G.sub.3                                  Q205         H        COEt           Gc                                       Q209         H        COEt           Gc                                       Q222         H        COEt           Gc                                       Q225         H        COEt           G.sub.3                                  Q229         H        COEt           Gc                                       Q246         H        COEt           G.sub.3                                  Q201         H        COPri          Gc                                       Q202         H        COPri          G.sub.3                                  Q205         H        COPri          Gc                                       Q209         H        COPri          Gc                                       Q222         H        COPri          Gc                                       Q225         H        COPri          G.sub.3                                  Q229         H        COPri          Gc                                       Q246         H        COPri          Gc                                       Q201         H        COPh           Gc                                       Q202         H        COPh           G.sub.3                                  Q205         H        COPh           Gc                                       Q209         H        COPh           Gc                                       Q222         H        COPh           G.sub.3                                  Q225         H        COPh           Gc                                       Q229         H        COPh           Gc                                       Q246         H        COPh           G.sub.3                                  Q201         H        CN             Gc                                       CH.sub.2 - Q201                                                                            H        CN             G.sub.3                                  Q202         H        CN             Gc                                       Q205         H        CN             Gc                                       Q209         H        CN             Gc                                       Q222         H        CN             Gc                                       Q225         H        CN             Gc                                       Q229         H        CN             Gc                                       Q246         H        CN             G.sub.3                                  Q201         H        H              Gc                                       Q202         H        H              G.sub.3                                  Q205         H        H              Gc                                       Q207         H        H              Gc                                       Q222         H        H              Gc                                       Q225         H        H              G.sub.3                                  Q229         H        H              Gc                                       Q230         H        H              Gc                                       Q231         H        H              G.sub.3                                  Q237         H        H              Gc                                       Q246         H        H              Gc                                       Q247         H        H              G.sub.3                                  Q250         H        H              Gc                                       Q259         H        H              G.sub.3                                  Q260         H        H              Gc                                       Q263         H        H              G.sub.3                                  Q201         H        Me             Gc                                       Q202         H        Me             G.sub.3                                  Q205         H        Me             Gc                                       Q207         H        Me             G.sub.3                                  Q222         H        Me             Gc                                       Q225         H        Me             Gc                                       Q229         H        Me             Gc                                       Q230         H        Me             G.sub.3                                  Q231         H        Me             Gc                                       Q237         H        Me             Gc                                       Q246         H        Me             Gc                                       Q247         H        Me             G.sub.3                                  Q250         H        Me             Gc                                       Q259         H        Me             Gc                                       Q260         H        Me             Gc                                       Q263         H        Me             G.sub.3                                  Q201         H        Et             Gc                                       Q202         H        Et             G.sub.1                                  Q205         H        Et             Gc                                       Q209         H        Et             Gc                                       Q222         H        Et             G.sub.3                                  Q225         H        Et             Gc                                       Q229         H        Et             Gc                                       Q246         H        Et             G.sub.2                                  Q201         H        Pri            Gc                                       Q205         H        Pri            Gc                                       Q209         H        Pri            Gc                                       Q222         H        Pri            G.sub.3                                  Q229         H        Pri            Gc                                       Q201         H        CHCH.sub.2     Gc                                       Q205         H        CHCH.sub.2     G.sub.3                                  Q209         H        CHCH.sub.2     Gc                                       Q229         H        CHCH.sub.2     G.sub.3                                  Q201         H        CHCHMe         Gc                                       Q205         H        CHCHMe         Gc                                       Q201         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q205         H        CH.sub.2 CHCH.sub.2                                                                          G.sub.3                                  Q209         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q229         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q201         H        CH.sub.2 Cl    Gc                                       Q205         H        CH.sub.2 Cl    G.sub.3                                  Q209         H        CH.sub.2 Cl    Gc                                       Q229         H        CH.sub.2 Cl    Gc                                       Q201         H        CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         H        CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q209         H        CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q229         H        CH.sub.2 CH.sub.2 Cl                                                                         G.sub.2                                  Q201         H        CF.sub.3       Gc                                       Q205         H        CF.sub.3       G.sub.3                                  Q209         H        CF.sub.3       Gc                                       Q222         H        CF.sub.3       Gc                                       Q225         H        CF.sub.3       G.sub.3                                  Q229         H        CF.sub.3       G.sub.1                                  Q201         H        CFCFCl         Gc                                       Q205         H        CFCFCl         Gc                                       Q229         H        CFCFCl         G.sub.3                                  Q201         H        CH.sub.2 Ph    Gc                                       Q205         H        CH.sub.2 Ph    Gc                                       Q209         H        CH.sub.2 Ph    G.sub.3                                  Q201         H        Ph             Gc                                       Q202         H        Ph             G.sub.1                                  Q205         H        Ph             Gc                                       Q209         H        Ph             Gc                                       Q222         H        Ph             G.sub.3                                  Q225         H        Ph             Gc                                       Q229         H        Ph             Gc                                       Q246         H        Ph             G.sub.2                                  Q201         H        Ph2-Cl         Gc                                       Q205         H        Ph2-Cl         G.sub.1                                  Q209         H        Ph2-Cl         Gc                                       Q201         H        Ph2-Me         Gc                                       Q205         H        Ph2-Me         G.sub.3                                  Q209         H        Ph2-Me         Gc                                       Q225         H        Ph2-Me         Gc                                       Q229         H        Ph2-Me         G.sub.3                                  Q201         H        Cl             Gc                                       Q205         H        Cl             Gc                                       Q207         H        Cl             G.sub.3                                  Q222         H        Cl             Gc                                       Q225         H        Cl             Gc                                       Q229         H        Cl             G.sub.1                                  Q231         H        Cl             Gc                                       Q246         H        Cl             Gc                                       Q250         H        Cl             G.sub.3                                  Q259         H        Cl             Gc                                       Q260         H        Cl             Gc                                       Q201         H        Br             Gc                                       Q205         H        Br             G.sub.3                                  Q207         H        Br             Gc                                       Q229         H        Br             Gc                                       Q231         H        Br             G.sub.3                                  Q250         H        Br             Gc                                       Q259         H        Br             Gc                                       Q260         H        Br             G.sub.3                                  Q201         H        F              Gc                                       Q205         H        F              G.sub.3                                  Q209         H        F              Gc                                       Q229         H        F              Gc                                       Q246         H        F              G.sub.3                                  Q201         H        I              Gc                                       Q205         H        I              Gc                                       Q209         H        I              Gc                                       Q222         H        I              Gc                                       Q201         H        NO.sub.2       Gc                                       CH.sub.2 - Q201                                                                            H        NO.sub.2       G.sub.3                                  Q202         H        NO.sub.2       G.sub.3                                  Q205         H        NO.sub.2       Gc                                       Q207         H        NO.sub.2       Gc                                       Q222         H        NO.sub.2       G.sub.3                                  Q225         H        NO.sub.2       Gc                                       Q229         H        NO.sub.2       Gc                                       Q230         H        NO.sub.2       G.sub.1                                  Q231         H        NO.sub.2       Gc                                       Q237         H        NO.sub.2       Gc                                       Q246         H        NO.sub.2       Gc                                       Q247         H        NO.sub.2       G.sub.2                                  Q250         H        NO.sub.2       Gc                                       Q259         H        NO.sub.2       Gc                                       Q260         H        NO.sub.2       G.sub.3                                  Q263         H        NO.sub.2       Gc                                       Q201         H        NH.sub. 2      Gc                                       Q202         H        NH.sub.2       G.sub.3                                  Q205         H        NH.sub.2       Gc                                       Q209         H        NH.sub.2       Gc                                       Q222         H        NH.sub.2       G.sub.3                                  Q225         H        NH.sub.2       Gc                                       Q229         H        NH.sub.2       Gc                                       Q246         H        NH.sub.2       G.sub.3                                  Q201         H        NHMe           Gc                                       Q205         H        NHMe           Gc                                       Q209         H        NHMe           Gc                                       Q225         H        NHMe           Gc                                       Q229         H        NHMe           G.sub.3                                  Q201         H        NMe.sub.2      Gc                                       Q205         H        NMe.sub.2      Gc                                       Q209         H        NMe.sub.2      Gc                                       Q222         H        NMe.sub.2      G.sub.1                                  Q225         H        NMe.sub.2      Gc                                       Q229         H        NMe.sub.2      Gc                                       Q246         H        NMe.sub.2      G.sub.3                                  Q201         H        NMeEt          Gc                                       Q205         H        NMeEt          Gc                                       Q209         H        NMeEt          G.sub.3                                  Q222         H        NMeEt          Gc                                       Q225         H        NMeEt          Gc                                       Q229         H        NMeEt          G.sub.2                                  Q201         H        NHCOMe         Gc                                       Q202         H        NHCOMe         G.sub.3                                  Q205         H        NHCOMe         Gc                                       Q209         H        NHCOMe         Gc                                       Q222         H        NHCOMe         G.sub.3                                  Q225         H        NHCOMe         Gc                                       Q229         H        NHCOMe         Gc                                       Q246         H        NHCOMe         G.sub.3                                  Q201         H        NHCOEt         Gc                                       Q205         H        NHCOEt         Gc                                       Q209         H        NHCOEt         Gc                                       Q222         H        NHCOEt         G.sub.1                                  Q225         H        NHCOEt         Gc                                       Q229         H        NHCOEt         G.sub.3                                  Q201         H        NHSO.sub.2 Me  Gc                                       Q205         H        NHSO.sub.2 Me  Gc                                       Q209         H        NHSO.sub. 2 Me Gc                                       Q225         H        NHSO.sub.2 Me  G.sub.3                                  Q229         H        NHSO.sub.2 Me  G.sub.3                                  Q201         H        OMe            Gc                                       Q205         H        OMe            Gc                                       Q209         H        OMe            G.sub.3                                  Q222         H        OMe            Gc                                       Q225         H        OMe            Gc                                       Q229         H        OMe            G.sub.2                                  Q246         H        OMe            G.sub.1                                  Q201         H        OEt            Gc                                       Q205         H        OEt            Gc                                       Q209         H        OEt            Gc                                       Q222         H        OEt            G.sub.3                                  Q229         H        OEt            Gc                                       Q201         H        CH.sub.2 OMe   Gc                                       Q205         H        CH.sub.2 OMe   Gc                                       Q209         H        CH.sub.2 OMe   G.sub.3                                  Q222         H        CH.sub.2 OMe   Gc                                       Q201         H        SMe            Gc                                       Q205         H        SMe            Gc                                       Q209         H        SMe            Gc                                       Q222         H        SMe            G.sub.1                                  Q225         H        SMe            Gc                                       Q229         H        SMe            G.sub.3                                  Q201         H        SO.sub.2 Me    Gc                                       CH.sub.2 - Q201                                                                            H        SO.sub.2 Me    G.sub.3                                  Q202         H        SO.sub.2 Me    Gc                                       Q205         H        SO.sub.2 Me    Gc                                       Q209         H        SO.sub.2 Me    Gc                                       Q222         H        SO.sub.2 Me    G.sub.3                                  Q225         H        SO.sub.2 Me    Gc                                       Q229         H        SO.sub.2 Me    Gc                                       Q246         H        SO.sub.2 Me    G.sub.3                                  Q201         H        SO.sub.2 Ph    Gc                                       Q202         H        SO.sub.2 Ph    G.sub.1                                  Q205         H        SO.sub.2 Ph    Gc                                       Q209         H        SO.sub.2 Ph    Gc                                       Q222         H        SO.sub.2 Ph    Gc                                       Q225         H        SO.sub.2 Ph    G.sub.3                                  Q229         H        SO.sub.2 Ph    Gc                                       Q246         H        SO.sub.2 Ph    G.sub.1                                  Q201         H        SO.sub.2 OMe   Gc                                       Q205         H        SO.sub.2 OMe   Gc                                       Q209         H        SO.sub.2 OMe   Gc                                       Q222         H        SO.sub.2 OMe   Gc                                       Q229         H        SO.sub.2 OMe   G.sub.3                                  Q201         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q209         H        SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q225         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q229         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q246         H        SO.sub.2 NH.sub.2                                                                            G.sub.1                                  Q201         H        SO.sub.2 NHMe  Gc                                       Q205         H        SO.sub.2 NHMe  Gc                                       Q209         H        SO.sub.2 NHMe  G.sub.3                                  Q222         H        SO.sub.2 NHMe  Gc                                       Q225         H        SO.sub.2 NHMe  Gc                                       Q229         H        SO.sub.2 NHMe  Gc                                       Q246         H        SO.sub.2 NHMe  G.sub.2                                  Q201         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q202         H        SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q205         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q209         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q222         H        SO.sub.2 NMe.sub.2                                                                           G.sub.2                                  Q225         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q229         H        SO.sub.2 NMe.sub. 2                                                                          Gc                                       Q246         H        SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         Me       COOMe          Gc                                       CH.sub.2 - Q201                                                                            Me       COOMe          G.sub.3                                  Q201         Me       COOMe          G.sub.1                                  Q205         Me       COOMe          Gc                                       Q207         Me       COOMe          G.sub.3                                  Q209         Me       COOMe          Gc                                       Q222         Me       COOMe          Gc                                       Q225         Me       COOMe          G.sub.2                                  Q229         Me       COOMe          Gc                                       Q230         Me       COOMe          Gc                                       Q231         Me       COOMe          G.sub.3                                  Q237         Me       COOMe          Gc                                       Q246         Me       COOMe          Gc                                       Q247         Me       COOMe          G.sub.3                                  Q250         Me       COOMe          Gc                                       Q259         Me       COOMe          G.sub.1                                  Q260         Me       COOMe          Gc                                       Q263         Me       COOMe          G.sub.3                                  Q201         Me       COOEt          Gc                                       CH.sub.2 - Q201                                                                            Me       COOEt          G.sub.2                                  Q222         Me       COOEt          Gc                                       Q205         Me       COOEt          Gc                                       Q207         Me       COOEt          G.sub.3                                  Q209         Me       COOEt          Gc                                       Q222         Me       COOEt          Gc                                       Q225         Me       COOEt          G.sub.3                                  Q229         Me       COOEt          Gc                                       Q230         Me       COOEt          Gc                                       Q231         Me       COOEt          Gc                                       Q237         Me       COOEt          G.sub.1                                  Q246         Me       COOEt          Gc                                       Q247         Me       COOEt          Gc                                       Q250         Me       COOEt          Gc                                       Q259         Me       COOEt          G.sub.3                                  Q260         Me       COOEt          Gc                                       Q263         Me       COOEt          G.sub.3                                  Q201         Me       COOH           G.sub.1                                  Q205         Me       COOH           Gc                                       Q201         Me       COOPri         Gc                                       Q202         Me       COOPri         G.sub.3                                  Q205         Me       COOPri         Gc                                       Q209         Me       COOPri         Gc                                       Q222         Me       COOPri         G.sub.3                                  Q225         Me       COOPri         Gc                                       Q229         Me       COOPri         Gc                                       Q246         Me       COOPri         G.sub.1                                  Q201         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q205         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q222         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q229         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.1                                  Q201         Me       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q205         Me       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q222         Me       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q229         Me       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.1                                  Q201         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q205         Me       COOCH.sub.2 CCH                                                                              G.sub.2                                  Q222         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q229         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q201         Me       CONHMe         Gc                                       Q205         Me       CONHMe         G.sub.3                                  Q222         Me       CONHMe         Gc                                       Q229         Me       CONHMe         Gc                                       Q201         Me       CONMe.sub.2    Gc                                       Q205         Me       CONMe.sub.2    G.sub.3                                  Q222         Me       CONMe.sub.2    Gc                                       Q229         Me       CONMe.sub.2    Gc                                       Q201         Me       COMe           Gc                                       Q202         Me       COMe           G.sub.3                                  Q205         Me       COMe           Gc                                       Q207         Me       COMe           Gc                                       Q222         Me       COMe           G.sub.3                                  Q225         Me       COMe           Gc                                       Q229         Me       COMe           Gc                                       Q230         Me       COMe           G.sub.3                                  Q231         Me       COMe           Gc                                       Q237         Me       COMe           Gc                                       Q246         Me       COMe           Gc                                       Q247         Me       COMe           G.sub.2                                  Q250         Me       COMe           Gc                                       Q259         Me       COMe           Gc                                       Q260         Me       COMe           G.sub.1                                  Q263         Me       COMe           Gc                                       Q201         Me       COEt           Gc                                       Q205         Me       COEt           G.sub.3                                  Q222         Me       COEt           Gc                                       Q229         Me       COEt           Gc                                       Q201         Me       COPri          Gc                                       Q205         Me       COPri          G.sub.3                                  Q222         Me       COPri          Gc                                       Q229         Me       COPri          G.sub.1                                  Q201         Me       COPh           Gc                                       Q205         Me       COPh           Gc                                       Q222         Me       COPh           G.sub.3                                  Q229         Me       COPh           Gc                                       Q201         Me       CN             Gc                                       Q202         Me       CN             G.sub.3                                  Q205         Me       CN             Gc                                       Q209         Me       CN             Gc                                       Q222         Me       CN             G.sub.3                                  Q225         Me       CN             Gc                                       Q229         Me       CN             Gc                                       Q246         Me       CN             G.sub.1                                  Q201         Me       H              Gc                                       Q205         Me       H              Gc                                       Q222         Me       H              G.sub.3                                  Q229         Me       H              Gc                                       Q201         Me       Me             Gc                                       Q202         Me       Me             G.sub.3                                  Q205         Me       Me             Gc                                       Q209         Me       Me             Gc                                       Q222         Me       Me             Gc                                       Q225         Me       Me             Gc                                       Q229         Me       Me             G.sub.3                                  Q246         Me       Me             Gc                                       Q201         Me       Et             Gc                                       Q205         Me       Et             Gc                                       Q222         Me       Et             G.sub.3                                  Q229         Me       Et             Gc                                       Q201         Me       Pri            Gc                                       Q205         Me       Pri            G.sub.2                                  Q201         Me       CHCH.sub.2     Gc                                       Q205         Me       CHCH.sub.2     G.sub.3                                  Q201         Me       CHCHMe         G.sub.3                                  Q205         Me       CHCHMe         Gc                                       Q201         Me       CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q205         Me       CH.sub.2 CHCH.sub.2                                                                          G.sub.3                                  Q201         Me       CH.sub.2 Cl    Gc                                       Q205         Me       CH.sub.2 Cl    G.sub.2                                  Q222         Me       CH.sub.2 Cl    Gc                                       Q229         Me       CH.sub.2 Cl    G.sub.3                                  Q201         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q222         Me       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q229         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Me       CF.sub.3       Gc                                       Q205         Me       CF.sub.3       G.sub.3                                  Q222         Me       CF.sub.3       G.sub.3                                  Q229         Me       CF.sub.3       Gc                                       Q201         Me       CFCFCl         Gc                                       Q205         Me       CFCFCl         G.sub.3                                  Q201         Me       CH.sub.2 Ph    Gc                                       Q205         Me       CH.sub.2 Ph    G.sub.3                                  Q201         Me       Ph             Gc                                       Q202         Me       Ph             Gc                                       Q205         Me       Ph             Gc                                       Q209         Me       Ph             Gc                                       Q222         Me       Ph             G.sub.3                                  Q225         Me       Ph             G.sub.3                                  Q229         Me       Ph             Gc                                       Q246         Me       Ph             G.sub.3                                  Q201         Me       Ph2-Cl         Gc                                       Q205         Me       Ph2-Cl         G.sub.3                                  Q201         Me       Ph2-Me         Gc                                       Q205         Me       Ph2-Me         Gc                                       Q229         Me       Ph2-Me         G.sub.3                                  Q201         Me       Cl             Gc                                       Q202         Me       Cl             G.sub.3                                  Q205         Me       Cl             Gc                                       Q209         Me       Cl             Gc                                       Q222         Me       Cl             G.sub.3                                  Q225         Me       Cl             Gc                                       Q229         Me       Cl             Gc                                       Q246         Me       Cl             G.sub.3                                  Q201         Me       Br             Gc                                       Q205         Me       Br             G.sub.3                                  Q222         Me       Br             Gc                                       Q229         Me       Br             G.sub.1                                  Q201         Me       F              G.sub.1                                  Q205         Me       F              G.sub.1                                  Q201         Me       I              G.sub.1                                  Q205         Me       I              G.sub.1                                  Q201         Me       NO.sub.2       Gc                                       Q202         Me       NO.sub.2       G.sub.3                                  Q205         Me       NO.sub.2       Gc                                       Q209         Me       NO.sub.2       Gc                                       Q222         Me       NO.sub.2       Gc                                       Q225         Me       NO.sub.2       G.sub.3                                  Q229         Me       NO.sub.2       Gc                                       Q246         Me       NO.sub.2       Gc                                       Q201         Me       NH.sub.2       Gc                                       Q205         Me       NH.sub.2       G.sub.3                                  Q222         Me       NH.sub.2       Gc                                       Q229         Me       NH.sub.2       G.sub.3                                  Q201         Me       NHMe           Gc                                       Q205         Me       NHMe           Gc                                       Q229         Me       NHMe           G.sub.3                                  Q201         Me       NMe.sub.2      Gc                                       Q205         Me       NMe.sub.2      Gc                                       Q229         Me       NMe.sub.2      G.sub.3                                  Q201         Me       NMeEt          Gc                                       Q205         Me       NMeEt          Gc                                       Q201         Me       NHCOMe         Gc                                       Q205         Me       NHCOMe         Gc                                       Q222         Me       NHCOMe         G.sub.3                                  Q229         Me       NHCOMe         Gc                                       Q201         Me       NHCOEt         Gc                                       Q205         Me       NHCOEt         G.sub.3                                  Q201         Me       NHSO.sub.2 Me  Gc                                       Q205         Me       NHSO.sub.2 Me  Gc                                       Q229         Me       NHSO.sub.2 Me  G.sub.2                                  Q201         Me       OMe            Gc                                       Q205         Me       OMe            G.sub.3                                  Q222         Me       OMe            Gc                                       Q229         Me       OMe            G.sub.1                                  Q201         Me       OEt            Gc                                       Q205         Me       OEt            G.sub.3                                  Q201         Me       CH.sub.2 OMe   Gc                                       Q205         Me       CH.sub.2 OMe   Gc                                       Q229         Me       CH.sub.2 OMe   G.sub.3                                  Q201         Me       SMe            Gc                                       Q205         Me       SMe            G.sub.3                                  Q201         Me       SO.sub.2 Me    Gc                                       Q205         Me       SO.sub.2 Me    Gc                                       Q222         Me       SO.sub.2 Me    G.sub.1                                  Q229         Me       SO.sub.2 Me    G.sub.3                                  Q201         Me       SO.sub.2 Ph    Gc                                       Q205         Me       SO.sub.2 Ph    Gc                                       Q222         Me       SO.sub.2 Ph    G.sub.3                                  Q229         Me       SO.sub.2 Ph    Gc                                       Q201         Me       SO.sub.2 OMe   Gc                                       Q205         Me       SO.sub.2 OMe   G.sub.3                                  Q229         Me       SO.sub.2 OMe   Gc                                       Q201         Me       SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         Me       SO.sub.2 NH.sub.2                                                                            Gc                                       Q229         Me       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Me       SO.sub.2 NHMe  Gc                                       Q205         Me       SO.sub.2 NHMe  Gc                                       Q222         Me       SO.sub.2 NHMe  G.sub.1                                  Q229         Me       SO.sub.2 NHMe  Gc                                       Q201         Me       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q205         Me       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q222         Me       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q229         Me       SO.sub.2 NMe.sub.2                                                                           G.sub.1                                  Q201         Et       COOMe          Gc                                       Q205         Et       COOMe          Gc                                       Q229         Et       COOMe          G.sub.3                                  Q246         Et       COOMe          G.sub.3                                  Q201         Et       COOEt          Gc                                       Q202         Et       COOEt          G.sub.2                                  Q209         Et       COOEt          Gc                                       Q222         Et       COOEt          G.sub.3                                  Q225         Et       COOEt          Gc                                       Q201         Et       COOPri         G.sub.3                                  Q205         Et       COOPri         Gc                                       Q201         Et       COOCH.sub.2 CHCl                                                                             Gc                                       Q205         Et       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         Et       COOCH.sub.2 CCH                                                                              Gc                                       Q201         Et       CONHMe         Gc                                       Q201         Et       CONMe.sub.2    Gc                                       Q201         Et       COMe           Gc                                       Q205         Et       COMe           G.sub.3                                  Q229         Et       COMe           Gc                                       Q201         Et       COEt           Gc                                       Q201         Et       COPh           Gc                                       Q201         Et       CN             Gc                                       Q205         Et       CN             G.sub.3                                  Q229         Et       CN             Gc                                       Q201         Et       H              Gc                                       Q205         Et       H              G.sub.3                                  Q201         Et       Me             Gc                                       Q205         Et       Me             G.sub.3                                  Q201         Et       Et             Gc                                       Q205         Et       Pri            Gc                                       Q201         Et       CHCHMe         Gc                                       Q201         Et       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Et       CH.sub.2 Ph    G.sub.3                                  Q201         Et       Ph             Gc                                       Q205         Et       Ph             Gc                                       Q209         Et       Ph             Gc                                       Q229         Et       Ph             G.sub.3                                  Q201         Et       Ph2-Cl         Gc                                       Q205         Et       Ph2-Me         Gc                                       Q201         Et       Cl             Gc                                       Q205         Et       Cl             G.sub.2                                  Q201         Et       Br             Gc                                       Q205         Et       Br             G.sub.1                                  Q201         Et       F              Gc                                       Q201         Et       NO.sub.2       Gc                                       Q205         Et       NO.sub.2       G.sub.3                                  Q209         Et       NO.sub.2       Gc                                       Q201         Et       NH.sub.2       Gc                                       Q201         Et       NHMe           Gc                                       Q201         Et       NMe.sub.2      Gc                                       Q205         Et       NMe.sub.2      G.sub.3                                  Q201         Et       NHCOMe         Gc                                       Q205         Et       NHCOMe         Gc                                       Q201         Et       NHCOEt         Gc                                       Q201         Et       NHSO.sub.2 Me  Gc                                       Q201         Et       OMe            Gc                                       Q205         Et       OEt            G.sub.3                                  Q201         Et       CH.sub.2 OMe   Gc                                       Q201         Et       SMe            Gc                                       Q201         Et       SO.sub.2 Me    Gc                                       Q205         Et       SO.sub.2 Me    G.sub.3                                  Q201         Et       SO.sub.2 Ph    Gc                                       Q205         Et       SO.sub.2 Ph    G.sub.3                                  Q201         Et       SO.sub.2 OMe   Gc                                       Q201         Et       SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         Et       SO.sub.2 NHMe  G.sub.3                                  Q201         Et       SO.sub. 2 NMe.sub.2                                                                          Gc                                       Q205         Et       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         Cl       COOMe          Gc                                       Q209         Cl       COOMe          G.sub.3                                  Q229         Cl       COOMe          Gc                                       Q246         Cl       COOMe          G.sub.3                                  Q201         Cl       COOEt          Gc                                       Q205         Cl       COOEt          Gc                                       Q222         Cl       COOEt          G.sub.1                                  Q225         Cl       COOEt          Gc                                       Q246         Cl       COOEt          G.sub.3                                  Q201         Cl       COOPri         Gc                                       Q205         Cl       COOPri         G.sub.3                                  Q205         Cl       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q201         Cl       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         Cl       COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         Cl       CONHMe         Gc                                       Q201         Cl       CONMe.sub.2    G.sub.3                                  Q201         Cl       COMe           Gc                                       Q205         Cl       COMe           Gc                                       Q201         Cl       COEt           G.sub.3                                  Q201         Cl       COPri          Gc                                       Q201         Cl       COPh           G.sub.3                                  Q201         Cl       CN             Gc                                       Q205         Cl       CN             Gc                                       Q201         Cl       H              G.sub.3                                  Q201         Cl       Me             Gc                                       Q205         Cl       Me             G.sub.3                                  Q205         Cl       Et             Gc                                       Q201         Cl       Pri            G.sub.3                                  Q201         Cl       CHCHMe         Gc                                       Q201         Cl       CH.sub.2 CHCH.sub.2                                                                          G.sub.1                                  Q205         Cl       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Cl       Ph             Gc                                       Q205         Cl       Ph             Gc                                       Q209         Cl       Ph             G.sub.3                                  Q201         Cl       Ph2-Cl         Gc                                       Q205         Cl       Ph2-Me         G.sub.3                                  Q201         Cl       Cl             Gc                                       Q205         Cl       Cl             G.sub.3                                  Q201         Cl       Br             Gc                                       Q201         Cl       NO.sub.2       Gc                                       Q205         Cl       NO.sub.2       G.sub.3                                  Q209         Cl       NO.sub.2       Gc                                       Q201         Cl       NH.sub.2       Gc                                       Q201         Cl       NHMe           G.sub.1                                  Q201         Cl       NMe.sub.2      G.sub.3                                  Q201         Cl       NHCOMe         Gc                                       Q205         Cl       NHCOEt         Gc                                       Q201         Cl       NHSO.sub.2 Me  G.sub.3                                  Q201         Cl       OMe            Gc                                       Q201         Cl       CH.sub.2 OMe   G.sub.3                                  Q201         Cl       SO.sub.2 Me    Gc                                       Q201         Cl       SO.sub.2 Ph    Gc                                       Q201         Cl       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Cl       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q205         Cl       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         Br       COOMe          Gc                                       Q205         Br       COOMe          G.sub.3                                  Q209         Br       COOMe          G.sub.3                                  Q201         Br       COOEt          Gc                                       Q209         Br       COOEt          Gc                                       Q229         Br       COOEt          G.sub.3                                  Q201         Br       COOPri         G.sub.3                                  Q201         Br       COOCH.sub.2 CHCl                                                                             Gc                                       Q201         Br       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         Br       CONHMe         Gc                                       Q201         Br       CONMe.sub.2    G.sub.3                                  Q201         Br       COMe           Gc                                       Q205         Br       COMe           G.sub.3                                  Q201         Br       COEt           Gc                                       Q201         Br       COPh           G.sub.3                                  Q201         Br       CN             Gc                                       Q205         Br       CN             Gc                                       Q201         Br       H              G.sub.3                                  Q201         Br       Me             G.sub.2                                  Q201         Br       Et             G.sub.1                                  Q201         Br       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         Br       Ph             Gc                                       Q205         Br       Ph             Gc                                       Q209         Br       Ph             G.sub.3                                  Q201         Br       Ph2-Cl         G.sub.3                                  Q201         Br       Cl             Gc                                       Q201         Br       Br             Gc                                       Q205         Br       Br             G.sub.3                                  Q201         Br       NO.sub.2       Gc                                       Q209         Br       NO.sub.2       Gc                                       Q201         Br       NH.sub.2       Gc                                       Q201         Br       NMe.sub.2      G.sub.3                                  Q201         Br       NHCOMe         Gc                                       Q201         Br       OMe            G.sub.3                                  Q201         Br       CH.sub.2 OMe   Gc                                       Q201         Br       SMe            Gc                                       Q201         Br       SO.sub.2 Me    Gc                                       Q201         Br       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Br       SO.sub.2 NHMe  Gc                                       Q201         Br       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         SMe      COOMe          Gc                                       Q205         SMe      COOMe          Gc                                       Q209         SMe      COOMe          G.sub.3                                  Q201         SMe      COOEt          Gc                                       Q205         SMe      COOEt          Gc                                       Q209         SMe      COOEt          Gc                                       Q229         SMe      COOEt          G.sub.3                                  Q246         SMe      COOEt          Gc                                       Q201         SMe      COOPri         Gc                                       Q205         SMe      COOPri         G.sub.3                                  Q201         SMe      COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         SMe      COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         SMe      CONHMe         Gc                                       Q201         SMe      CONMe.sub.2    G.sub.1                                  Q201         SMe      COMe           Gc                                       Q205         SMe      COMe           Gc                                       Q201         SMe      COEt           G.sub.3                                  Q201         SMe      COPri          Gc                                       Q201         SMe      COPh           G.sub.3                                  Q201         SMe      CN             Gc                                       Q205         SMe      CN             Gc                                       Q229         SMe      CN             G.sub.3                                  Q201         SMe      H              Gc                                       Q201         SMe      Me             Gc                                       Q205         SMe      Me             G.sub.3                                  Q201         SMe      Et             Gc                                       Q205         SMe      Et             Gc                                       Q201         SMe      CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         SMe      Ph             Gc                                       Q205         SMe      Ph             Gc                                       Q209         SMe      Ph             G.sub.3                                  Q201         SMe      Ph2-Cl         Gc                                       Q201         SMe      Cl             Gc                                       Q205         SMe      Cl             G.sub.3                                  Q201         SMe      Br             Gc                                       Q201         SMe      NO.sub.2       Gc                                       Q205         SMe      NO.sub.2       Gc                                       Q209         SMe      NO.sub.2       G.sub.3                                  Q201         SMe      NH.sub.2       Gc                                       Q205         SMe      NH.sub.2       Gc                                       Q201         SMe      NHMe           G.sub.3                                  Q201         SMe      NMe.sub.2      Gc                                       Q205         SMe      NMe.sub.2      Gc                                       Q201         SMe      NHCOMe         Gc                                       Q205         SMe      NHCOMe         G.sub.3                                  Q201         SMe      NHSO.sub.2 Me  Gc                                       Q201         SMe      OMe            Gc                                       Q201         SMe      CH.sub.2 OMe   Gc                                       Q201         SMe      SMe            Gc                                       Q201         SMe      SO.sub.2 Me    Gc                                       Q205         SMe      SO.sub.2 Me    G.sub.3                                  Q201         SMe      SO.sub.2 Ph    Gc                                       Q201         SMe      SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         SMe      SO.sub.2 NHMe  G.sub.3                                  Q201         SMe      SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         SO.sub.2 Me                                                                            COOMe          Gc                                       Q205         SO.sub.2 Me                                                                            COOMe          Gc                                       Q209         SO.sub.2 Me                                                                            COOMe          G.sub.3                                  Q229         SO.sub.2 Me                                                                            COOMe          G.sub.3                                  Q246         SO.sub.2 Me                                                                            COOMe          G.sub.1                                  Q201         SO.sub.2 Me                                                                            COOEt          Gc                                       Q205         SO.sub.2 Me                                                                            COOEt          Gc                                       Q209         SO.sub.2 Me                                                                            COOEt          G.sub.3                                  Q222         SO.sub.2 Me                                                                            COOEt          Gc                                       Q225         SO.sub.2 Me                                                                            COOEt          Gc                                       Q201         SO.sub.2 Me                                                                            COOPri         G.sub.3                                  Q205         SO.sub.2 Me                                                                            COOPri         Gc                                       Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CCH                                                                              Gc                                       Q201         SO.sub.2 Me                                                                            CONHMe         Gc                                       Q201         SO.sub.2 Me                                                                            CONMe.sub.2    G.sub.2                                  Q201         SO.sub.2 Me                                                                            COMe           Gc                                       Q205         SO.sub.2 Me                                                                            COMe           Gc                                       Q229         SO.sub.2 Me                                                                            COMe           G.sub.3                                  Q201         SO.sub.2 Me                                                                            COEt           Gc                                       Q205         SO.sub.2 Me                                                                            COEt           Gc                                       Q201         SO.sub.2 Me                                                                            COPri          G.sub.3                                  Q201         SO.sub.2 Me                                                                            COPh           Gc                                       Q201         SO.sub.2 Me                                                                            CN             Gc                                       Q205         SO.sub.2 Me                                                                            CN             Gc                                       Q222         SO.sub.2 Me                                                                            CN             Gc                                       Q229         SO.sub.2 Me                                                                            CN             Gc                                       Q201         SO.sub.2 Me                                                                            H              G.sub.2                                  Q201         SO.sub.2 Me                                                                            Me             Gc                                       Q205         SO.sub.2 Me                                                                            Me             Gc                                       Q201         SO.sub.2 Me                                                                            Et             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Pri            Gc                                       Q201         SO.sub.2 Me                                                                            CHCH.sub.2     Gc                                       Q201         SO.sub.2 Me                                                                            CHCHMe         G.sub.1                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 Ph    G.sub.3                                  Q201         SO.sub.2 Me                                                                            Ph             Gc                                       Q205         SO.sub.2 Me                                                                            Ph             Gc                                       Q209         SO.sub.2 Me                                                                            Ph             Gc                                       Q229         SO.sub.2 Me                                                                            Ph             G.sub.3                                  Q246         SO.sub.2 Me                                                                            Ph             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Ph2-Cl         Gc                                       Q205         SO.sub.2 Me                                                                            Ph2-Me         Gc                                       Q201         SO.sub.2 Me                                                                            Cl             Gc                                       Q205         SO.sub.2 Me                                                                            Cl             Gc                                       Q229         SO.sub.2 Me                                                                            Cl             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Br             G.sub.3                                  Q205         SO.sub.2 Me                                                                            Br             Gc                                       Q201         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q205         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q209         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q229         SO.sub.2 Me                                                                            NO.sub.2       G.sub.3                                  Q201         SO.sub.2 Me                                                                            NH.sub.2       Gc                                       Q205         SO.sub.2 Me                                                                            NH.sub.2       G.sub.3                                  Q201         SO.sub.2 Me                                                                            NHMe           Gc                                       Q201         SO.sub.2 Me                                                                            NMe.sub.2      Gc                                       Q205         SO.sub.2 Me                                                                            NMe.sub.2      G.sub.1                                  Q201         SO.sub.2 Me                                                                            NHCOMe         Gc                                       Q205         SO.sub.2 Me                                                                            NHCOMe         Gc                                       Q201         SO.sub.2 Me                                                                            NHCOEt         G.sub.3                                  Q201         SO.sub.2 Me                                                                            NHSO.sub.2 Me  Gc                                       Q201         SO.sub.2 Me                                                                            OMe            G.sub.1                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 OMe   Gc                                       Q205         SO.sub.2 Me                                                                            CH.sub.2 OMe   Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 Me    Gc                                       Q205         SO.sub.2 Me                                                                            SO.sub.2 Me    Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 Ph    G.sub.3                                  Q201         SO.sub.2 Me                                                                            SO.sub.2 OMe   Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 NHMe  G.sub.3                                  Q201         SO.sub.2 Me                                                                            SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         Ph       COOMe          Gc                                       Q205         Ph       COOMe          G.sub.3                                  Q209         Ph       COOMe          Gc                                       Q201         Ph       COOEt          Gc                                       Q205         Ph       COOEt          Gc                                       Q209         Ph       COOEt          G.sub.3                                  Q229         Ph       COOEt          Gc                                       Q201         Ph       COOPri         G.sub.3                                  Q201         Ph       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         Ph       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         Ph       COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         Ph       CONMe.sub.2    Gc                                       Q201         Ph       COMe           Gc                                       Q205         Ph       COMe           Gc                                       Q201         Ph       COEt           G.sub.3                                  Q201         Ph       CN             Gc                                       Q205         Ph       CN             Gc                                       Q201         Ph       H              G.sub.3                                  Q201         Ph       Me             Gc                                       Q201         Ph       Et             Gc                                       Q201         Ph       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         Ph       Ph             Gc                                       Q205         Ph       Ph             Gc                                       Q209         Ph       Ph             G.sub.3                                  Q201         Ph       Cl             Gc                                       Q201         Ph       Br             G.sub.3                                  Q201         Ph       NO.sub.2       Gc                                       Q201         Ph       NH.sub.2       Gc                                       Q201         Ph       NHMe           G.sub.3                                  Q201         Ph       NMe.sub.2      Gc                                       Q201         Ph       NHCOMe         Gc                                       Q201         Ph       NHSO.sub.2 Me  G.sub.1                                  Q201         Ph       CH.sub.2 OMe   Gc                                       Q201         Ph       SO.sub.2 Me    G.sub.3                                  Q201         Ph       SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         Ph       SO.sub.2 NHMe  Gc                                       Q201         Ph       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  ______________________________________                                    

                  TABLE 2                                                         ______________________________________                                         ##STR25##                                                                    A            B        D              Gn                                       ______________________________________                                        Q1           H        COOMe          Gb                                       CH.sub.2 - Q1                                                                              H        COOMe          Gc                                       CHMe - Q1    H        COOMe          G3                                       Q2           H        COOMe          Gb                                       Q3           H        COOMe          Gb                                       Q4           H        COOMe          Gb                                       Q5           H        COOMe          Ga                                       CH.sub.2 - Q5                                                                              H        COOMe          Gc                                       CHMe - Q5    H        COOMe          G3                                       Q6           H        COOMe          G3                                       Q7           H        COOMe          G3                                       Q8           H        COOMe          G3                                       Q9           H        COOMe          Gc                                       CH.sub.2 - Q9                                                                              H        COOMe          Gc                                       Q10          H        COOMe          Gc                                       Q11          H        COOMe          G3                                       Q12          H        COOMe          G3                                       Q13          H        COOMe          G3                                       Q14          H        COOMe          G1                                       Q15          H        COOMe          G3                                       Q16          H        COOMe          Gc                                       Q17          H        COOMe          Gc                                       Q18          H        COOMe          G3                                       Q19          H        COOMe          Gc                                       Q20          H        COOMe          Gc                                       Q21          H        COOMe          Gc                                       Q22          H        COOMe          G3                                       Q23          H        COOMe          Gc                                       CH.sub.2 - Q23                                                                             H        COOMe          G3                                       Q24          H        COOMe          Gc                                       Q25          H        COOMe          Gb                                       Q26          H        COOMe          Ga                                       CH.sub.2 - Q26                                                                             H        COOMe          G3                                       CHMe - Q26   H        COOMe          G3                                       Q27          H        COOMe          G3                                       Q28          H        COOMe          G3                                       Q29          H        COOMe          Gc                                       CH.sub.2 - Q29                                                                             H        COOMe          G3                                       Q30          H        COOMe          G3                                       Q31          H        COOMe          Gc                                       Q32          H        COOMe          Gc                                       CH.sub.2 - Q32                                                                             H        COOMe          G3                                       Q33          H        COOMe          G3                                       Q34          H        COOMe          G3                                       Q35          H        COOMe          G3                                       Q36          H        COOMe          G3                                       Q37          H        COOMe          Gc                                       Q38          H        COOMe          Gc                                       Q39          H        COOMe          G3                                       Q40          H        COOMe          Gc                                       Q41          H        COOMe          Gc                                       Q42          H        COOMe          Gc                                       Q43          H        COOMe          G3                                       Q44          H        COOMe          Gc                                       Q45          H        COOMe          Gc                                       Q46          H        COOMe          Gc                                       Q47          H        COOMe          Gc                                       Q48          H        COOMe          Gc                                       Q49          H        COOMe          G3                                       Q50          H        COOMe          Gc                                       CH.sub.2 - Q50                                                                             H        COOMe          G3                                       Q51          H        COOMe          Gc                                       Q52          H        COOMe          G3                                       Q53          H        COOMe          G3                                       Q54          H        COOMe          Gc                                       Q55          H        COOMe          Gc                                       Q56          H        COOMe          Gc                                       Q57          H        COOMe          G3                                       Q58          H        COOMe          Gc                                       Q59          H        COOMe          Gc                                       CH.sub.2 - Q59                                                                             H        COOMe          G3                                       Q60          H        COOMe          Gc                                       Q61          H        COOMe          Ga                                       CH.sub.2 - Q61                                                                             H        COOMe          Gb                                       CHMe - Q61   H        COOMe          Gc                                       Q62          H        COOMe          Gc                                       Q63          H        COOMe          Gc                                       Q64          H        COOMe          Gb                                       CH.sub.2 - Q64                                                                             H        COOMe          G3                                       CHMe - Q64   H        COOMe          G3                                       Q65          H        COOMe          G3                                       Q66          H        COOMe          G3                                       Q67          H        COOMe          G3                                       Q68          H        COOMe          G3                                       Q69          H        COOMe          Gc                                       Q70          H        COOMe          Gc                                       Q71          H        COOMe          Gc                                       Q72          H        COOMe          Gc                                       CH.sub.2 - Q72                                                                             H        COOMe          G3                                       CHMe - Q72   H        COOMe          G3                                       Q73          H        COOMe          Gc                                       CH.sub.2 - Q73                                                                             H        COOMe          G3                                       Q74          H        COOMe          Gc                                       Q75          H        COOMe          G3                                       Q76          H        COOMe          G3                                       Q77          H        COOMe          Gc                                       CH.sub.2 - Q77                                                                             H        COOMe          G3                                       Q78          H        COOMe          Gc                                       Q79          H        COOMe          Gc                                       Q80          H        COOMe          Gc                                       Q81          H        COOMe          G3                                       Q82          H        COOMe          G3                                       Q83          H        COOMe          G1                                       Q84          H        COOMe          G2                                       Q85          H        COOMe          G3                                       Q86          H        COOMe          Gc                                       Q87          H        COOMe          G2                                       Q88          H        COOMe          Gc                                       Q89          H        COOMe          Gc                                       Q90          H        COOMe          Gc                                       Q91          H        COOMe          Gc                                       Q92          H        COOMe          G3                                       Q93          H        COOMe          Gc                                       Q94          H        COOMe          G3                                       Q95          H        COOMe          Gc                                       Q96          H        COOMe          G3                                       Q97          H        COOMe          Gc                                       Q98          H        COOMe          Gc                                       Q99          H        COOMe          Gc                                       Q100         H        COOMe          Gc                                       Q101         H        COOMe          Gc                                       CH.sub. 2 - Q101                                                                           H        COOMe          G3                                       Q102         H        COOMe          G3                                       Q103         H        COOMe          G3                                       Q104         H        COOMe          G3                                       Q105         H        COOMe          Gc                                       Q106         H        COOMe          G3                                       Q107         H        COOMe          Gc                                       Q108         H        COOMe          G1                                       Q109         H        COOMe          G3                                       Q110         H        COOMe          G3                                       Q111         H        COOMe          G3                                       Q112         H        COOMe          Gc                                       Q113         H        COOMe          Gc                                       Q114         H        COOMe          Gc                                       Q115         H        COOMe          G2                                       Q116         H        COOMe          Gc                                       Q117         H        COOMe          Gc                                       Q118         H        COOMe          G3                                       Q119         H        COOMe          Gc                                       Q120         H        COOMe          Gc                                       Q121         H        COOMe          G2                                       Q122         H        COOMe          Gc                                       Q123         H        COOMe          Gc                                       Q124         H        COOMe          Gc                                       Q125         H        COOMe          Gc                                       Q126         H        COOMe          Gc                                       Q127         H        COOMe          Gc                                       Q128         H        COOMe          Gc                                       Q129         H        COOMe          Gc                                       Q130         H        COOMe          G2                                       Q131         H        COOMe          Gc                                       Q132         H        COOMe          Gc                                       Q133         H        COOMe          G3                                       Q134         H        COOMe          G3                                       Q135         H        COOMe          Gc                                       Q136         H        COOMe          G3                                       Q137         H        COOMe          G1                                       Q138         H        COOMe          Gc                                       CH.sub.2 - Q138                                                                            H        COOMe          G3                                       Q139         H        COOMe          G3                                       Q140         H        COOMe          G1                                       Q141         H        COOMe          G3                                       Q142         H        COOMe          Gc                                       Q143         H        COOMe          Gc                                       CH.sub.2 - Q143                                                                            H        COOMe          G3                                       Q144         H        COOMe          G3                                       Q145         H        COOMe          Gc                                       Q146         H        COOMe          Gc                                       Q147         H        COOMe          G3                                       Q148         H        COOMe          G1                                       Q149         H        COOMe          G3                                       Q150         H        COOMe          G3                                       Q151         H        COOMe          G2                                       Q152         H        COOMe          G1                                       Q153         H        COOMe          Gc                                       Q154         H        COOMe          Gc                                       Q155         H        COOMe          G3                                       Q156         H        COOMe          G3                                       Q157         H        COOMe          Gc                                       Q158         H        COOMe          Ga                                       CH.sub.2 - Q158                                                                            H        COOMe          G3                                       CHMe - Q158  H        COOMe          G3                                       Q159         H        COOMe          G3                                       Q160         H        COOMe          Gc                                       Q161         H        COOMe          Gc                                       Q162         H        COOMe          Gc                                       Q163         H        COOMe          G3                                       Q164         H        COOMe          Gc                                       Q165         H        COOMe          Gc                                       Q166         H        COOMe          Gc                                       Q167         H        COOMe          G3                                       Q168         H        COOMe          G3                                       Q169         H        COOMe          Gc                                       CH.sub.2 - Q169                                                                            H        COOMe          G3                                       CHMe - Q169  H        COOMe          G3                                       Q170         H        COOMe          Gc                                       Q171         H        COOMe          Gc                                       Q172         H        COOMe          Gc                                       Q173         H        COOMe          Gc                                       Q174         H        COOMe          Gc                                       Q175         H        COOMe          Gc                                       Q176         H        COOMe          Gc                                       Q177         H        COOMe          Gc                                       CH.sub.2 - Q177                                                                            H        COOMe          G3                                       CHMe - Q177  H        COOMe          G3                                       Q178         H        COOMe          G3                                       Q179         H        COOMe          G3                                       Q180         H        COOMe          Gc                                       CH.sub.2 - Q180                                                                            H        COOMe          G3                                       Q181         H        COOMe          G1                                       Q182         H        COOMe          G3                                       Q183         H        COOMe          G3                                       Q184         H        COOMe          Gc                                       CH.sub.2 - Q184                                                                            H        COOMe          G3                                       CHMe - Q184  H        COOMe          G3                                       Q185         H        COOMe          G3                                       Q186         H        COOMe          G3                                       Q187         H        COOMe          G3                                       Q188         H        COOMe          Gb                                       Q189         H        COOMe          Gb                                       Q1           H        COOEt          Gb                                       CH.sub.2 - Q1                                                                              H        COOEt          Gc                                       CHMe - Q1    H        COOEt          G3                                       Q2           H        COOEt          Gb                                       Q3           H        COOEt          Gb                                       Q4           H        COOEt          Gb                                       Q5           H        COOEt          Ga                                       CH.sub.2 - Q5                                                                              H        COOEt          Gc                                       CHMe - Q5    H        COOEt          G3                                       Q6           H        COOEt          G3                                       Q7           H        COOEt          G3                                       Q8           H        COOEt          G3                                       Q9           H        COOEt          Gc                                       CH.sub.2 - Q9                                                                              H        COOEt          Gc                                       Q10          H        COOEt          Gc                                       Q11          H        COOEt          G3                                       Q12          H        COOEt          G3                                       Q13          H        COOEt          G3                                       Q14          H        COOEt          G1                                       Q15          H        COOEt          G3                                       Q16          H        COOEt          Gc                                       Q17          H        COOEt          Gc                                       Q18          H        COOEt          G3                                       Q19          H        COOEt          Gc                                       Q20          H        COOEt          Gc                                       Q21          H        COOEt          Gc                                       Q22          H        COOEt          G3                                       Q23          H        COOEt          Gc                                       CH.sub.2 - Q23                                                                             H        COOEt          G3                                       Q24          H        COOEt          Gc                                       Q25          H        COOEt          Gb                                       Q26          H        COOEt          Ga                                       CH.sub.2 - Q26                                                                             H        COOEt          G3                                       CHMe - Q26   H        COOEt          G3                                       Q27          H        COOEt          G3                                       Q28          H        COOEt          G3                                       Q29          H        COOEt          Gc                                       CH.sub.2 - Q29                                                                             H        COOEt          G3                                       Q30          H        COOEt          G3                                       Q31          H        COOEt          Gc                                       Q32          H        COOEt          Gc                                       CH.sub.2 - Q32                                                                             H        COOEt          G3                                       Q33          H        COOEt          G3                                       Q34          H        COOEt          G3                                       Q35          H        COOEt          G3                                       Q36          H        COOEt          G3                                       Q37          H        COOEt          Gc                                       Q38          H        COOEt          Gc                                       Q39          H        COOEt          G3                                       Q40          H        COOEt          Gc                                       Q41          H        COOEt          Gc                                       Q42          H        COOEt          Gc                                       Q43          H        COOEt          G3                                       Q44          H        COOEt          Gc                                       Q45          H        COOEt          Gc                                       Q46          H        COOEt          Gc                                       Q47          H        COOEt          Gc                                       Q48          H        COOEt          Gc                                       Q49          H        COOEt          G3                                       Q50          H        COOEt          Gc                                       CH.sub.2 - Q50                                                                             H        COOEt          G3                                       Q51          H        COOEt          Gc                                       Q52          H        COOEt          G3                                       Q53          H        COOEt          G3                                       Q54          H        COOEt          Gc                                       Q55          H        COOEt          Gc                                       Q56          H        COOEt          Gc                                       Q57          H        COOEt          G3                                       Q58          H        COOEt          Gc                                       Q59          H        COOEt          Gc                                       CH.sub.2 - Q59                                                                             H        COOEt          G3                                       Q60          H        COOEt          Gc                                       Q61          H        COOEt          Ga                                       CH.sub.2 - Q61                                                                             H        COOEt          Gb                                       CHMe - Q61   H        COOEt          Gc                                       Q62          H        COOEt          Gc                                       Q63          H        COOEt          Gc                                       Q64          H        COOEt          Gb                                       CH.sub. 2 - Q64                                                                            H        COOEt          G3                                       CHMe - Q64   H        COOEt          G3                                       Q65          H        COOEt          G3                                       Q66          H        COOEt          G3                                       Q67          H        COOEt          G3                                       Q68          H        COOEt          G3                                       Q69          H        COOEt          Gc                                       Q70          H        COOEt          Gc                                       Q71          H        COOEt          Gc                                       Q72          H        COOEt          Gc                                       CH.sub.2 - Q72                                                                             H        COOEt          G3                                       CHMe - Q72   H        COOEt          G3                                       Q73          H        COOEt          Gc                                       CH.sub.2 - Q73                                                                             H        COOEt          G3                                       Q74          H        COOEt          Gc                                       Q75          H        COOEt          G3                                       Q76          H        COOEt          G3                                       Q77          H        COOEt          Gc                                       CH.sub.2 - Q77                                                                             H        COOEt          G3                                       Q78          H        COOEt          Gc                                       Q79          H        COOEt          Gc                                       Q80          H        COOEt          Gc                                       Q81          H        COOEt          G3                                       Q82          H        COOEt          G3                                       Q83          H        COOEt          G1                                       Q84          H        COOEt          G2                                       Q85          H        COOEt          G3                                       Q86          H        COOEt          Gc                                       Q87          H        COOEt          G2                                       Q88          H        COOEt          Gc                                       Q89          H        COOEt          Gc                                       Q90          H        COOEt          Gc                                       Q91          H        COOEt          Gc                                       Q92          H        COOEt          G3                                       Q93          H        COOEt          Gc                                       Q94          H        COOEt          G3                                       Q95          H        COOEt          Gc                                       Q96          H        COOEt          G3                                       Q97          H        COOEt          Gc                                       Q98          H        COOEt          Gc                                       Q99          H        COOEt          Gc                                       Q100         H        COOEt          Gc                                       Q101         H        COOEt          Gc                                       CH.sub.2 - Q101                                                                            H        COOEt          G3                                       Q102         H        COOEt          G3                                       Q103         H        COOEt          G3                                       Q104         H        COOEt          G3                                       Q105         H        COOEt          Gc                                       Q106         H        COOEt          G3                                       Q107         H        COOEt          Gc                                       Q108         H        COOEt          G1                                       Q109         H        COOEt          G3                                       Q110         H        COOEt          G3                                       Q111         H        COOEt          G3                                       Q112         H        COOEt          Gc                                       Q113         H        COOEt          Gc                                       Q114         H        COOEt          Gc                                       Q115         H        COOEt          G2                                       Q116         H        COOEt          Gc                                       Q117         H        COOEt          Gc                                       Q118         H        COOEt          G3                                       Q119         H        COOEt          Gc                                       Q120         H        COOEt          Gc                                       Q121         H        COOEt          G2                                       Q122         H        COOEt          Gc                                       Q123         H        COOEt          Gc                                       Q124         H        COOEt          Gc                                       Q125         H        COOEt          Gc                                       Q126         H        COOEt          Gc                                       Q127         H        COOEt          Gc                                       Q128         H        COOEt          Gc                                       Q129         H        COOEt          Gc                                       Q130         H        COOEt          G2                                       Q131         H        COOEt          Gc                                       Q132         H        COOEt          Gc                                       Q133         H        COOEt          G3                                       Q134         H        COOEt          G3                                       Q135         H        COOEt          Gc                                       Q136         H        COOEt          G3                                       Q137         H        COOEt          G1                                       Q138         H        COOEt          Gc                                       CH.sub.2 - Q138                                                                            H        COOEt          G3                                       Q139         H        COOEt          G3                                       Q140         H        COOEt          G1                                       Q141         H        COOEt          G3                                       Q142         H        COOEt          Gc                                       Q143         H        COOEt          Gc                                       CH.sub.2 - Q143                                                                            H        COOEt          G3                                       Q144         H        COOEt          G3                                       Q145         H        COOEt          Gc                                       Q146         H        COOEt          Gc                                       Q147         H        COOEt          G3                                       Q148         H        COOEt          G1                                       Q149         H        COOEt          G3                                       Q150         H        COOEt          G3                                       Q151         H        COOEt          G2                                       Q152         H        COOEt          G1                                       Q153         H        COOEt          Gc                                       Q154         H        COOEt          Gc                                       Q155         H        COOEt          G3                                       Q156         H        COOEt          G3                                       Q157         H        COOEt          Gc                                       Q158         H        COOEt          Ga                                       CH.sub.2 - Q158                                                                            H        COOEt          G3                                       CHMe - Q158  H        COOEt          G3                                       Q159         H        COOEt          G3                                       Q160         H        COOEt          Gc                                       Q161         H        COOEt          Gc                                       Q162         H        COOEt          Gc                                       Q163         H        COOEt          G3                                       Q164         H        COOEt          Gc                                       Q165         H        COOEt          Gc                                       Q166         H        COOEt          Gc                                       Q167         H        COOEt          G3                                       Q168         H        COOEt          G3                                       Q169         H        COOEt          Gc                                       CH.sub.2 - Q169                                                                            H        COOEt          G3                                       CHMe - Q169  H        COOEt          G3                                       Q170         H        COOEt          Gc                                       Q171         H        COOEt          Gc                                       Q172         H        COOEt          Gc                                       Q173         H        COOEt          Gc                                       Q174         H        COOEt          Gc                                       Q175         H        COOEt          Gc                                       Q176         H        COOEt          Gc                                       Q177         H        COOEt          Gc                                       CH.sub.2 - Q177                                                                            H        COOEt          G3                                       CHMe - Q177  H        COOEt          G3                                       Q178         H        COOEt          G3                                       Q179         H        COOEt          G3                                       Q180         H        COOEt          Gc                                       CH.sub.2 - Q180                                                                            H        COOEt          G3                                       Q181         H        COOEt          G1                                       Q182         H        COOEt          G3                                       Q183         H        COOEt          G3                                       Q184         H        COOEt          Gc                                       CH.sub.2  - Q184                                                                           H        COOEt          G3                                       CHMe - Q184  H        COOEt          G3                                       Q185         H        COOEt          G3                                       Q186         H        COOEt          G3                                       Q187         H        COOEt          G3                                       Q188         H        COOEt          Gb                                       Q189         H        COOEt          Gb                                       Q5           H        COOPri         G3                                       Q26          H        COOPri         G3                                       Q61          H        COOPri         G3                                       Q158         H        COOPri         G3                                       Q5           H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q61          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q158         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q189         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q26          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q61          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           H        COOCH.sub.2 CCH                                                                              G3                                       Q26          H        COOCH.sub.2 CCH                                                                              G3                                       Q61          H        COOCH.sub.2 CCH                                                                              G3                                       Q158         H        COOCH.sub.2 CCH                                                                              G3                                       Q1           H        COOPri         G3                                       Q2           H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q4           H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q7           H        COOCH.sub.2 CCH                                                                              G3                                       Q9           H        COOPri         G3                                       Q10          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q19          H        COOPri         G3                                       Q23          H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q32          H        COOCH.sub.2 CCH                                                                              G3                                       Q41          H        COOPri         G3                                       Q45          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q50          H        COOCH.sub.2 CCH                                                                              G3                                       Q69          H        COOPri         G3                                       Q79          H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q83          H        COOCH.sub.2 CCH                                                                              G3                                       Q96          H        COOPri         G3                                       Q124         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q131         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q132         H        COOCH.sub.2 CCH                                                                              G3                                       Q135         H        COOPri         G3                                       Q138         H        COOPri         G3                                       Q142         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q157         H        COOPri         G3                                       Q159         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q177         H        COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q180         H        COOCH.sub.2 CCH                                                                              G3                                       Q184         H        COOPri         G3                                       Q5           H        COOH           G3                                       Q26          H        COOH           G3                                       Q61          H        COOH           G3                                       Q158         H        COOH           G3                                       Q5           H        CONHMe         G3                                       Q26          H        CONHMe         G3                                       Q61          H        CONHMe         G3                                       Q158         H        CONHMe         G3                                       Q5           H        CONMe.sub.2    G3                                       Q26          H        CONMe.sub.2    G3                                       Q61          H        CONMe.sub.2    G3                                       Q158         H        CONMe.sub.2    G3                                       Q5           H        COMe           G3                                       Q26          H        COMe           G3                                       Q61          H        COMe           G3                                       Q188         H        COMe           Gb                                       Q189         H        COMe           Gb                                       Q158         H        COMe           G3                                       Q5           H        COEt           G3                                       Q26          H        COEt           G3                                       Q61          H        COEt           G3                                       Q158         H        COEt           G3                                       Q188         H        COEt           Gb                                       Q189         H        COEt           Gb                                       Q5           H        COPri          G3                                       Q26          H        COPri          G3                                       Q61          H        COPri          G3                                       Q158         H        COPri          G3                                       Q5           H        COPh           G3                                       Q26          H        COPh           G3                                       Q61          H        COPh           G3                                       Q158         H        COPh           G3                                       Q1           H        COMe           G3                                       Q2           H        COEt           G3                                       Q4           H        COMe           G3                                       Q7           H        COMe           G3                                       Q9           H        COEt           G3                                       Q10          H        COPri          G3                                       Q19          H        COPh           G3                                       Q23          H        COMe           G3                                       Q32          H        COMe           G3                                       Q41          H        COPri          G3                                       Q45          H        COPh           G3                                       Q50          H        COMe           G3                                       Q69          H        COEt           G3                                       Q79          H        COPri          G3                                       Q83          H        COPh           G3                                       Q96          H        COMe           G3                                       Q124         H        COEt           G3                                       Q131         H        COMe           G3                                       Q132         H        COMe           G3                                       Q135         H        COEt           G3                                       Q138         H        COPri          G3                                       Q142         H        COPh           G3                                       Q157         H        COMe           G3                                       Q159         H        COEt           G3                                       Q177         H        COMe           G3                                       Q180         H        COMe           G3                                       Q184         H        COPri          G3                                       Q4           H        CN             G3                                       Q5           H        CN             G3                                       Q7           H        CN             G3                                       Q9           H        CN             G3                                       Q23          H        CN             G3                                       Q26          H        CN             G3                                       Q32          H        CN             G3                                       Q61          H        CN             G3                                       Q96          H        CN             G3                                       Q142         H        CN             G3                                       Q158         H        CN             G3                                       Q5           H        H              G3                                       Q26          H        H              G3                                       Q61          H        H              G3                                       Q158         H        H              G3                                       Q5           H        Me             G3                                       Q26          H        Me             G3                                       Q61          H        Me             G3                                       Q158         H        Me             G3                                       Q5           H        Et             G3                                       Q26          H        Et             G3                                       Q61          H        Et             G3                                       Q158         H        Et             G3                                       Q5           H        Pri            G3                                       Q26          H        Pri            G3                                       Q61          H        Pri            G3                                       Q158         H        Pri            G3                                       Q5           H        CHCH.sub.2     G3                                       Q26          H        CHCH.sub.2     G3                                       Q61          H        CHCHMe         G3                                       Q158         H        CHCHMe         G3                                       Q5           H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q26          H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q61          H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q158         H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q1           H        H              G3                                       Q2           H        Me             G3                                       Q4           H        Me             G3                                       Q7           H        Me             G3                                       Q9           H        Et             G3                                       Q10          H        Pri            G3                                       Q19          H        Me             G3                                       Q23          H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q32          H        H              G3                                       Q41          H        Me             G3                                       Q45          H        Me             G3                                       Q50          H        Et             G3                                       Q69          H        Pri            G3                                       Q79          H        Me             G3                                       Q83          H        Et             G3                                       Q96          H        Me             G3                                       Q124         H        Et             G3                                       Q131         H        Me             G3                                       Q132         H        CH.sub.2 CHCH.sub.2                                                                          G3                                       Q135         H        Et             G3                                       Q138         H        Pri            G3                                       Q142         H        H              G3                                       Q157         H        Me             G3                                       Q159         H        Me             G3                                       Q177         H        H              G3                                       Q180         H        Me             G3                                       Q184         H        Me             G3                                       Q5           H        CH.sub.2 Cl    G3                                       Q26          H        CH.sub.2 Cl    G3                                       Q61          H        CH.sub.2 Cl    G3                                       Q158         H        CH.sub.2 Cl    G3                                       Q5           H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q61          H        CH.sub.2 CH.sub. 2 Cl                                                                        G3                                       Q158         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q5           H        CF.sub.3       G3                                       Q26          H        CF.sub.3       G3                                       Q61          H        CF.sub.3       G3                                       Q158         H        CF.sub.3       G3                                       Q5           H        CFCFCl         G3                                       Q26          H        CFCFCl         G3                                       Q61          H        CH.sub.2 Ph    G3                                       Q158         H        CH.sub.2 Ph    G3                                       Q5           H        Ph             G3                                       Q26          H        Ph             G3                                       Q61          H        Ph             G3                                       Q158         H        Ph             G3                                       Q5           H        Ph2-Cl         G3                                       Q26          H        Ph2-Me         G3                                       Q61          H        Ph2-Cl         G3                                       Q158         H        Ph2-Me         G3                                       Q1           H        Ph             G3                                       Q2           H        CH.sub.2 Cl    G3                                       Q4           H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q7           H        Ph             G3                                       Q9           H        CF.sub.3       G3                                       Q10          H        CF.sub.3       G3                                       Q19          H        CFCFCl         G3                                       Q23          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q32          H        Ph             G3                                       Q41          H        Ph2-Cl         G3                                       Q45          H        Ph2-Me         G3                                       Q50          H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q69          H        Ph             G3                                       Q79          H        CF.sub.3       G3                                       Q83          H        CF.sub.3       G3                                       Q96          H        Ph             G3                                       Q124         H        Ph2-Cl         G3                                       Q131         H        Ph2-Me         G3                                       Q132         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q135         H        Ph             G3                                       Q138         H        CF.sub.3       G3                                       Q142         H        CF.sub.3       G3                                       Q157         H        CFCFCl         G3                                       Q159         H        CH.sub.2 Cl    G3                                       Q177         H        CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q180         H        Ph             G3                                       Q184         H        Ph2-Cl         G3                                       Q5           H        Cl             G3                                       Q26          H        Cl             G3                                       Q61          H        Cl             G3                                       Q158         H        Cl             G3                                       Q5           H        Br             G3                                       Q26          H        Br             G3                                       Q61          H        Br             G3                                       Q158         H        Br             G3                                       Q5           H        F              G3                                       Q26          H        F              G3                                       Q61          H        I              G3                                       Q158         H        I              G3                                       Q1           H        Cl             G3                                       Q2           H        Cl             G3                                       Q4           H        Cl             G3                                       Q7           H        Br             G3                                       Q9           H        F              G3                                       Q10          H        I              G3                                       Q19          H        Cl             G3                                       Q23          H        Cl             G3                                       Q32          H        Cl             G3                                       Q41          H        Br             G3                                       Q45          H        Br             G3                                       Q50          H        F              G3                                       Q69          H        Cl             G3                                       Q79          H        F              G3                                       Q83          H        Cl             G3                                       Q96          H        Cl             G3                                       Q124         H        Cl             G3                                       Q131         H        Br             G3                                       Q132         H        Br             G3                                       Q135         H        F              G3                                       Q138         H        Br             G3                                       Q142         H        Cl             G3                                       Q157         H        Cl             G3                                       Q159         H        Cl             G3                                       Q177         H        Br             G3                                       Q180         H        Br             G3                                       Q184         H        Cl             G3                                       Q4           H        NO.sub.2       G3                                       Q5           H        NO.sub.2       G3                                       Q7           H        NO.sub.2       G3                                       Q9           H        NO.sub.2       G3                                       Q23          H        NO.sub.2       G3                                       Q26          H        NO.sub.2       G3                                       Q32          H        NO.sub.2       G3                                       Q61          H        NO.sub.2       G3                                       Q96          H        NO.sub.2       G3                                       Q142         H        NO.sub.2       G3                                       Q158         H        NO.sub.2       G3                                       Q5           H        NH.sub.2       G3                                       Q26          H        NH.sub.2       G3                                       Q61          H        NH.sub.2       G3                                       Q158         H        NH.sub.2       G3                                       Q5           H        NHMe           G3                                       Q26          H        NHMe           G3                                       Q61          H        NHMe           G3                                       Q158         H        NHMe           G3                                       Q5           H        NMe.sub.2      G3                                       Q26          H        NMe.sub.2      G3                                       Q61          H        NMe.sub.2      G3                                       Q158         H        NMe.sub.2      G3                                       Q5           H        NMeEt          G3                                       Q26          H        NMeEt          G3                                       Q61          H        NMeEt          G3                                       Q158         H        NMeEt          G3                                       Q5           H        NHSO.sub.2 Me  G3                                       Q26          H        NHSO.sub.2 Me  G3                                       Q61          H        NHSO.sub.2 Me  G3                                       Q158         H        NHSO.sub.2 Me  G3                                       Q1           H        NH.sub.2       G3                                       Q2           H        NH.sub.2       G3                                       Q4           H        NH.sub.2       G3                                       Q7           H        NHMe           G3                                       Q9           H        NHMe           G3                                       Q10          H        NMe.sub.2      G3                                       Q19          H        NMeEt          G3                                       Q23          H        NMe.sub.2      G3                                       Q32          H        NMeEt          G3                                       Q41          H        NH.sub.2       G3                                       Q45          H        NH.sub.2       G3                                       Q50          H        NHMe           G3                                       Q69          H        NHMe           G3                                       Q79          H        NMe.sub.2      G3                                       Q83          H        NMeEt          G3                                       Q96          H        NHSO.sub.2 Me  G3                                       Q124         H        NMe.sub.2      G3                                       Q131         H        NMeEt          G3                                       Q132         H        NH.sub.2       G3                                       Q135         H        NH.sub.2       G3                                       Q138         H        NHMe           G3                                       Q142         H        NHMe           G3                                       Q157         H        NHSO.sub.2 Me  G3                                       Q159         H        NMe.sub.2      G3                                       Q177         H        NMeEt          G3                                       Q180         H        NH.sub.2       G3                                       Q184         H        NH.sub.2       G3                                       Q4           H        NHCOMe         G3                                       Q5           H        NHCOMe         G3                                       Q7           H        NHCOMe         G3                                       Q9           H        NHCOMe         G3                                       Q23          H        NHCOMe         G3                                       Q26          H        NHCOMe         G3                                       Q32          H        NHCOMe         G3                                       Q61          H        NHCOMe         G3                                       Q96          H        NHCOMe         G3                                       Q142         H        NHCOMe         G3                                       Q158         H        NHCOMe         G3                                       Q5           H        NHCOEt         G3                                       Q26          H        NHCOEt         G3                                       Q61          H        NHCOEt         G3                                       Q158         H        NHCOEt         G3                                       Q5           H        OMe            G3                                       Q26          H        OMe            G3                                       Q61          H        OMe            G3                                       Q158         H        OMe            G3                                       Q5           H        OEt            G3                                       Q26          H        OEt            G3                                       Q61          H        OEt            G3                                       Q158         H        OEt            G3                                       Q5           H        CH.sub.2 OMe   G3                                       Q26          H        CH.sub.2 OMe   G3                                       Q61          H        CH.sub.2 OMe   G3                                       Q158         H        CH.sub.2 OMe   G3                                       Q5           H        SMe            G3                                       Q26          H        SMe            G3                                       Q61          H        SMe            G3                                       Q158         H        SMe            G3                                       Q5           H        SO.sub.2 OMe   G3                                       Q26          H        SO.sub.2 OMe   G3                                       Q61          H        SO.sub.2 OMe   G3                                       Q158         H        SO.sub.2 OMe   G3                                       Q1           H        OMe            G3                                       Q2           H        OMe            G3                                       Q4           H        OEt            G3                                       Q7           H        SO.sub.2 OMe   G3                                       Q9           H        CH.sub.2 OMe   G3                                       Q10          H        SMe            G3                                       Q19          H        SO.sub.2 OMe   G3                                       Q23          H        OMe            G3                                       Q32          H        OEt            G3                                       Q41          H        SO.sub.2 OMe   G3                                       Q45          H        CH.sub.2 OMe   G3                                       Q50          H        SMe            G3                                       Q69          H        SO.sub.2 OMe   G3                                       Q79          H        OMe            G3                                       Q83          H        OEt            G3                                       Q96          H        CH.sub.2 OMe   G3                                       Q124         H        SMe            G3                                       Q131         H        OMe            G3                                       Q132         H        OEt            G3                                       Q135         H        CH.sub.2 OMe   G3                                       Q138         H        SMe            G3                                       Q142         H        SO.sub.2 OMe   G3                                       Q157         H        OMe            G3                                       Q159         H        OEt            G3                                       Q177         H        SO.sub.2 OMe   G3                                       Q180         H        OMe            G3                                       Q184         H        OEt            G3                                       Q4           H        SO.sub.2 Me    G3                                       Q5           H        SO.sub.2 Me    G3                                       Q7           H        SO.sub.2 Me    G3                                       Q9           H        SO.sub.2 Me    G3                                       Q23          H        SO.sub.2 Me    G3                                       Q26          H        SO.sub.2 Me    G3                                       Q32          H        SO.sub.2 Me    G3                                       Q61          H        SO.sub.2 Me    G3                                       Q96          H        SO.sub.2 Me    G3                                       Q142         H        SO.sub.2 Me    G3                                       Q158         H        SO.sub.2 Me    G3                                       Q188         H        SO.sub.2 Me    Gb                                       Q189         H        SO.sub.2 Me    Gb                                       Q5           H        SO.sub.2 Ph    G3                                       Q26          H        SO.sub.2 Ph    G3                                       Q61          H        SO.sub.2 Ph    G3                                       Q158         H        SO.sub.2 Ph    G3                                       Q5           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q26          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q61          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q158         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q5           H        SO.sub.2 NHMe  G3                                       Q26          H        SO.sub.2 NHMe  G3                                       Q61          H        SO.sub.2 NHMe  G3                                       Q158         H        SO.sub.2 NHMe  G3                                       Q5           H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q26          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q61          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q158         H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q188         H        SO.sub.2 NMe.sub.2                                                                           Gb                                       Q189         H        SO.sub.2 NMe.sub.2                                                                           Gb                                       Q1           H        SO.sub.2 Me    G3                                       Q2           H        SO.sub.2 Me    G3                                       Q4           H        SO.sub.2 Ph    G3                                       Q7           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q9           H        SO.sub.2 NH.sub.2                                                                            G3                                       Q10          H        SO.sub.2 Ph    G3                                       Q19          H        SO.sub.2 Me    G3                                       Q23          H        SO.sub.2 Ph    G3                                       Q32          H        SO.sub. 2 NHMe G3                                       Q41          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q45          H        SO.sub.2 Me    G3                                       Q50          H        SO.sub.2 NH.sub.2                                                                            G3                                       Q69          H        SO.sub.2 Me    G3                                       Q79          H        SO.sub.2 Ph    G3                                       Q83          H        SO.sub.2 Me    G3                                       Q96          H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q124         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q131         H        SO.sub.2 Me    G3                                       Q132         H        SO.sub.2 Me    G3                                       Q135         H        SO.sub.2 NHMe  G3                                       Q138         H        SO.sub.2 NMe.sub.2                                                                           G3                                       Q142         H        SO.sub.2 NH.sub.2                                                                            G3                                       Q157         H        SO.sub.2 Me    G3                                       Q159         H        SO.sub.2 Me    G3                                       Q177         H        SO.sub.2 NHMe  G3                                       Q180         H        SO.sub.2 NHMe.sub.2                                                                          G3                                       Q184         H        SO.sub.2 Me    G3                                       Q1           Me       COOMe          G3                                       Q2           Me       COOMe          G3                                       Q4           Me       COOMe          G3                                       Q5           Me       COOMe          G3                                       Q7           Me       COOMe          G3                                       Q9           Me       COOMe          G3                                       Q10          Me       COOMe          G3                                       Q19          Me       COOMe          G3                                       Q23          Me       COOMe          G3                                       Q26          Me       COOMe          G3                                       Q32          Me       COOMe          G3                                       Q41          Me       COOMe          G3                                       Q45          Me       COOMe          G3                                       Q50          Me       COOMe          G3                                       Q61          Me       COOMe          G3                                       Q69          Me       COOMe          G3                                       Q79          Me       COOMe          G3                                       Q83          Me       COOMe          G3                                       Q96          Me       COOMe          G3                                       Q124         Me       COOMe          G3                                       Q131         Me       COOMe          G3                                       Q132         Me       COOMe          G3                                       Q135         Me       COOMe          G3                                       Q138         Me       COOMe          G3                                       Q142         Me       COOMe          G3                                       Q157         Me       COOMe          G3                                       Q158         Me       COOMe          G3                                       Q159         Me       COOMe          G3                                       Q177         Me       COOMe          G3                                       Q180         Me       COOMe          G3                                       Q184         Me       COOMe          G3                                       Q1           Me       COOEt          G3                                       Q2           Me       COOEt          G3                                       Q4           Me       COOEt          G3                                       Q5           Me       COOEt          G3                                       Q7           Me       COOEt          G3                                       Q9           Me       COOEt          G3                                       Q10          Me       COOEt          G3                                       Q19          Me       COOEt          G3                                       Q23          Me       COOEt          G3                                       Q26          Me       COOEt          G3                                       Q32          Me       COOEt          G3                                       Q41          Me       COOEt          G3                                       Q45          Me       COOEt          G3                                       Q50          Me       COOEt          G3                                       Q61          H        COOEt          G3                                       Q69          Me       COOEt          G3                                       Q79          Me       COOEt          G3                                       Q83          Me       COOEt          G3                                       Q96          Me       COOEt          G3                                       Q124         Me       COOEt          G3                                       Q131         Me       COOEt          G3                                       Q132         Me       COOEt          G3                                       Q135         Me       COOEt          G3                                       Q138         Me       COOEt          G3                                       Q142         Me       COOEt          G3                                       Q157         Me       COOEt          G3                                       Q158         Me       COOEt          G3                                       Q159         Me       COOEt          G3                                       Q177         Me       COOEt          G3                                       Q180         Me       COOEt          G3                                       Q184         Me       COOEt          G3                                       Q158         Me       COOEt          G3                                       Q5           Me       COOPri         G3                                       Q26          Me       COOPri         G3                                       Q61          Me       COOPri         G3                                       Q158         Me       COOPri         G3                                       Q5           Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q61          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q158         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q26          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q61          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           Me       COOCH.sub.2 CCH                                                                              G3                                       Q26          Me       COOCH.sub.2 CCH                                                                              G3                                       Q61          Me       COOCH.sub.2 CCH                                                                              G3                                       Q158         Me       COOCH.sub.2 CCH                                                                              G3                                       Q5           Me       CONHMe         G3                                       Q26          Me       CONHMe         G3                                       Q61          Me       CONHMe         G3                                       Q158         Me       CONHMe         G3                                       Q5           Me       CONMe.sub.2    G3                                       Q26          Me       CONMe.sub.2    G3                                       Q61          Me       CONMe.sub.2    G3                                       Q158         Me       CONMe.sub.2    G3                                       Q1           Me       COOPri         G3                                       Q2           Me       COOPri         G3                                       Q4           Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q7           Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q9           Me       COOCH.sub.2 CCH                                                                              G3                                       Q10          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q19          Me       COOPri         G3                                       Q23          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q32          Me       CONMe.sub.2    G3                                       Q41          Me       COOPri         G3                                       Q45          Me       CONHMe         G3                                       Q50          Me       CONMe.sub.2    G3                                       Q69          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q79          Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q83          Me       COOPri         G3                                       Q96          Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q124         Me       COOPri         G3                                       Q131         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q132         Me       CONHMe         G3                                       Q135         Me       CONMe.sub.2    G3                                       Q138         Me       COOCH.sub.2 CCH                                                                              G3                                       Q142         Me       COOPri         G3                                       Q157         Me       COOPri         G3                                       Q159         Me       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q177         Me       COOCH.sub.2 CCH                                                                              G3                                       Q180         Me       COOPri         G3                                       Q184         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Me       COMe           G3                                       Q26          Me       COMe           G3                                       Q61          Me       COMe           G3                                       Q158         Me       COMe           G3                                       Q5           Me       COEt           G3                                       Q26          Me       COEt           G3                                       Q61          Me       COEt           G3                                       Q158         Me       COEt           G3                                       Q5           Me       COPri          G3                                       Q26          Me       COPri          G3                                       Q61          Me       COPri          G3                                       Q158         Me       COPr i         G3                                       Q5           Me       CN             G3                                       Q26          Me       CN             G3                                       Q61          Me       CN             G3                                       Q158         Me       CN             G3                                       Q5           Me       H              G3                                       Q26          Me       H              G3                                       Q61          Me       H              G3                                       Q158         Me       H              G3                                       Q5           Me       Me             G3                                       Q26          Me       Me             G3                                       Q61          Me       Me             G3                                       Q158         Me       Me             G3                                       Q5           Me       Et             G3                                       Q26          Me       Et             G3                                       Q61          Me       Et             G3                                       Q158         Me       Et             G3                                       Q5           Me       Pri            G3                                       Q26          Me       Pri            G3                                       Q61          Me       CHCH.sub.2     G3                                       Q158         Me       CHCH.sub.2     G3                                       Q5           Me       CHCHMe         G3                                       Q26          Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q61          Me       CHCHMe         G3                                       Q158         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q1           Me       COMe           G3                                       Q2           Me       COEt           G3                                       Q4           Me       CHCHMe         G3                                       Q7           Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q9           Me       CN             G3                                       Q10          Me       H              G3                                       Q19          Me       Me             G3                                       Q23          Me       COMe           G3                                       Q32          Me       COEt           G3                                       Q41          Me       H              G3                                       Q45          Me       Me             G3                                       Q50          Me       COPri          G3                                       Q69          Me       CN             G3                                       Q79          Me       Et             G3                                       Q83          Me       Pri            G3                                       Q96          Me       COMe           G3                                       Q124         Me       COEt           G3                                       Q131         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q132         Me       Me             G3                                       Q135         Me       COPr-i         G3                                       Q138         Me       CN             G3                                       Q142         Me       Et             G3                                       Q157         Me       CH.sub.2 CHCH.sub.2                                                                          G3                                       Q159         Me       COMe           G3                                       Q177         Me       COEt           G3                                       Q180         Me       CHCHMe         G3                                       Q184         Me       COMe           G3                                       Q5           Me       CH.sub.2 Cl    G3                                       Q26          Me       CH.sub.2 Cl    G3                                       Q5           Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q61          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q5           Me       CF.sub.3       G3                                       Q26          Me       CF.sub.3       G3                                       Q61          Me       CF.sub.3       G3                                       Q158         Me       CF.sub.3       G3                                       Q5           Me       CFCFCl         G3                                       Q26          Me       CFCFCl         G3                                       Q61          Me       CH.sub.2 Ph    G3                                       Q158         Me       CH.sub.2 Ph    G3                                       Q5           Me       Ph             G3                                       Q26          Me       Ph             G3                                       Q61          Me       Ph             G3                                       Q158         Me       Ph             G3                                       Q5           Me       Ph2-Cl         G3                                       Q26          Me       Ph2-Cl         G3                                       Q61          Me       Ph2-Me         G3                                       Q158         Me       Ph2-Me         G3                                       Q5           Me       Cl             G3                                       Q26          Me       Cl             G3                                       Q61          Me       Cl             G3                                       Q158         Me       Cl             G3                                       Q5           Me       Br             G3                                       Q26          Me       Br             G3                                       Q61          Me       Br             G3                                       Q158         Me       Br             G3                                       Q5           Me       F              G3                                       Q26          Me       F              G3                                       Q61          Me       I              G3                                       Q158         Me       I              G3                                       Q1           Me       Ph             G3                                       Q2           Me       Cl             G3                                       Q4           Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q7           Me       Ph             G3                                       Q9           Me       Ph             G3                                       Q10          Me       Cl             G3                                       Q19          Me       Cl             G3                                       Q23          Me       Br             G3                                       Q32          Me       CH.sub.2 Cl    G3                                       Q41          Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q45          Me       CF.sub.3       G3                                       Q50          Me       Cl             G3                                       Q69          Me       Cl             G3                                       Q79          Me       Br             G3                                       Q83          Me       Ph             G3                                       Q96          Me       CF.sub.3       G3                                       Q124         Me       CF.sub.3       G3                                       Q131         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q132         Me       Ph             G3                                       Q135         Me       Br             G3                                       Q138         Me       Ph             G3                                       Q142         Me       Ph             G3                                       Q157         Me       Cl             G3                                       Q159         Me       Br             G3                                       Q177         Me       CF.sub.3       G3                                       Q180         Me       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q184         Me       Ph             G3                                       Q5           Me       NO.sub.2       G3                                       Q26          Me       NO.sub.2       G3                                       Q61          Me       NO.sub.2       G3                                       Q158         Me       NO.sub.2       G3                                       Q5           Me       NH.sub.2       G3                                       Q26          Me       NH.sub.2       G3                                       Q61          Me       NH.sub.2       G3                                       Q158         Me       NH.sub.2       G3                                       Q5           Me       NHMe           G3                                       Q26          Me       NHMe           G3                                       Q61          Me       NHMe           G3                                       Q158         Me       NHMe           G3                                       Q5           Me       NMe.sub.2      G3                                       Q26          Me       NMe.sub.2      G3                                       Q61          Me       NMe.sub.2      G3                                       Q158         Me       NMe.sub.2      G3                                       Q5           Me       NMeEt          G3                                       Q26          Me       NMeEt          G3                                       Q5           Me       NHCOMe         G3                                       Q26          Me       NHCOMe         G3                                       Q61          Me       NHCOMe         G3                                       Q158         Me       NHCOMe         G3                                       Q5           Me       NHCOEt         G3                                       Q26          Me       NHCOEt         G3                                       Q61          Me       NHSO.sub.2 Me  G3                                       Q158         Me       NHSO.sub.2 Me  G3                                       Q5           Me       OMe            G3                                       Q26          Me       OMe            G3                                       Q61          Me       OMe            G3                                       Q158         Me       OMe            G3                                       Q5           Me       OEt            G3                                       Q26          Me       OEt            G3                                       Q61          Me       CH.sub.2 OMe   G3                                       Q158         Me       CH.sub.2 OMe   G3                                       Q1           Me       NO.sub.2       G3                                       Q2           Me       NHCOMe         G3                                       Q4           Me       NHCOEt         G3                                       Q7           Me       NHMe           G3                                       Q9           Me       NO.sub.2       G3                                       Q10          Me       NH.sub.2       G3                                       Q19          Me       NHCOMe         G3                                       Q23          Me       OMe            G3                                       Q32          Me       NHCOMe         G3                                       Q41          Me       NHCOEt         G3                                       Q45          Me       CH.sub.2 OMe   G3                                       Q50          Me       OMe            G3                                       Q69          Me       OEt            G3                                       Q79          Me       NO.sub.2       G3                                       Q83          Me       NH.sub.2       G3                                       Q96          Me       NMe.sub.2      G3                                       Q124         Me       NMeEt          G3                                       Q131         Me       NHCOMe         G3                                       Q132         Me       NHCOEt         G3                                       Q135         Me       NO.sub.2       G3                                       Q138         Me       OMe            G3                                       Q142         Me       OEt            G3                                       Q157         Me       NO.sub.2       G3                                       Q159         Me       NH.sub.2       G3                                       Q177         Me       OMe            G3                                       Q180         Me       NHCOMe         G3                                       Q184         Me       NO.sub.2       G3                                       Q26          Me       SMe            G3                                       Q61          Me       SMe            G3                                       Q5           Me       SO.sub.2 Me    G3                                       Q26          Me       SO.sub.2 Me    G3                                       Q61          Me       SO.sub.2 Me    G3                                       Q158         Me       SO.sub.2 Me    G3                                       Q5           Me       SO.sub.2 Ph    G3                                       Q26          Me       SO.sub.2 Ph    G3                                       Q61          Me       SO.sub.2 Ph    G3                                       Q158         Me       SO.sub.2 Ph    G3                                       Q5           Me       SO.sub.2 OMe   G3                                       Q26          Me       SO.sub.2 OMe   G3                                       Q61          Me       SO.sub.2 NH.sub.2                                                                            G3                                       Q158         Me       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Me       SO.sub.2 NMe   G3                                       Q26          Me       SO.sub.2 NMe   G3                                       Q61          Me       SO.sub.2 NMe   G3                                       Q158         Me       SO.sub.2 NMe   G3                                       Q5           Me       SO.sub.2 NHMe.sub.2                                                                          G3                                       Q26          Me       SO.sub.2 NHMe.sub.2                                                                          G3                                       Q61          Me       SO.sub.2 NHMe.sub.2                                                                          G3                                       Q158         Me       SO.sub.2 NHMe.sub.2                                                                          G3                                       Q1           Me       SO.sub.2 Ph    G3                                       Q2           Me       SO.sub.2 OMe   G3                                       Q4           Me       SO.sub.2 NHMe  G3                                       Q7           Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q9           Me       SO.sub.2 Me    G3                                       Q10          Me       SO.sub.2 Me    G3                                       Q19          Me       SMe            G3                                       Q23          Me       SO.sub.2 Me    G3                                       Q32          Me       SO.sub.2 OMe   G3                                       Q41          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q45          Me       SO.sub.2 NHMe  G3                                       Q50          Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q69          Me       SO.sub.2 Me    G3                                       Q79          Me       SO.sub.2 Me    G3                                       Q83          Me       SO.sub.2 Ph    G3                                       Q96          Me       SO.sub.2 OMe   G3                                       Q124         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q131         Me       SO.sub.2 NHMe  G3                                       Q132         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q135         Me       SO.sub.2 Ph    G3                                       Q138         Me       SO.sub.2 Ph    G3                                       Q142         Me       SO.sub.2 Me    G3                                       Q157         Me       SO.sub.2 Me    G3                                       Q159         Me       SO.sub.2 NHMe  G3                                       Q177         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q180         Me       SO.sub.2 NMe.sub.2                                                                           G3                                       Q184         Me       SO.sub.2 Me.sub.2                                                                            G3                                       Q5           Et       COOMe          G3                                       Q26          Et       COOMe          G3                                       Q61          Et       COOMe          G3                                       Q142         Et       COOMe          G3                                       Q158         Et       COOMe          G3                                       Q159         Et       COOMe          G3                                       Q4           Et       COOEt          G3                                       Q5           Et       COOEt          G3                                       Q9           Et       COOEt          G3                                       Q26          Et       COOEt          G3                                       Q32          Et       COOEt          G3                                       Q61          Et       COOEt          G3                                       Q69          Et       COOEt          G3                                       Q96          Et       COOEt          G3                                       Q158         Et       COOEt          G3                                       Q61          Et       COOPri         G3                                       Q158         Et       COOPri         G3                                       Q5           Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q26          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q158         Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q5           Et       COOCH.sub.2 CCH                                                                              G3                                       Q26          Et       COOCH.sub.2 CCH                                                                              G3                                       Q5           Et       CONHMe         G3                                       Q26          Et       CONMe.sub.2    G3                                       Q1           Et       COOPri         G3                                       Q4           Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q69          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q79          Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q83          Et       COOPri         G3                                       Q96          Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q131         Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q157         Et       COOPri         G3                                       Q159         Et       COOCH.sub.2 CHCH.sub.2                                                                       G3                                       Q184         Et       COOCH.sub.2 CH.sub.2 Cl                                                                      G3                                       Q5           Et       COMe           G3                                       Q26          Et       COMe           G3                                       Q158         Et       COEt           G3                                       Q5           Et       COPri          G3                                       Q26          Et       CN             G3                                       Q61          Et       H              G3                                       Q26          Et       Me             G3                                       Q158         Et       Et             G3                                       Q5           Et       Pri            G3                                       Q1           Et       COMe           G3                                       Q2           Et       COEt           G3                                       Q9           Et       CN             G3                                       Q23          Et       COMe           G3                                       Q96          Et       COMe           G3                                       Q124         Et       COEt           G3                                       Q135         Et       COPri          G3                                       Q138         Et       CN             G3                                       Q5           Et       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q26          Et       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Et       CF.sub.3       G3                                       Q5           Et       Ph             G3                                       Q26          Et       Ph             G3                                       Q158         Et       Ph2-Me         G3                                       Q26          Et       Cl             G3                                       Q61          Et       Cl             G3                                       Q5           Et       Br             G3                                       Q1           Et       Ph             G3                                       Q2           Et       Cl             G3                                       Q9           Et       Ph             G3                                       Q5           Et       NO.sub.2       G3                                       Q5           Et       NH.sub.2       G3                                       Q5           Et       NHMe           G3                                       Q26          Et       NMe.sub.2      G3                                       Q61          Et       NHCOMe         G3                                       Q158         Et       NHSO.sub.2 Me  G3                                       Q2           Et       NHCOMe         G3                                       Q23          Et       OMe            G3                                       Q32          Et       NHCOMe         G3                                       Q96          Et       NMe.sub.2      G3                                       Q26          Et       SO.sub.2 Me    G3                                       Q61          Et       SO.sub.2 Me    G3                                       Q5           Et       SO.sub.2 Ph    G3                                       Q26          Et       SO.sub.2 OMe   G3                                       Q61          Et       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Et       SO.sub.2 NHMe  G3                                       Q26          Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q4           Et       SO.sub.2 NHMe  G3                                       Q7           Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q9           Et       SO.sub.2 Me    G3                                       Q142         Et       SO.sub.2 Me    G3                                       Q159         Et       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           Cl       COOMe          G3                                       Q26          Cl       COOMe          G3                                       Q61          Cl       COOMe          G3                                       Q5           Cl       COOEt          G3                                       Q26          Cl       COOEt          G3                                       Q61          Cl       COOEt          G3                                       Q96          Cl       COOEt          G3                                       Q158         Cl       COOEt          G3                                       Q61          Cl       COOPri         G3                                       Q5           Cl       COMe           G3                                       Q158         Cl       COEt           G3                                       Q5           Cl       COPri          G3                                       Q26          Cl       CN             G3                                       Q61          Cl       H              G3                                       Q26          Cl       Me             G3                                       Q158         Cl       Et             G3                                       Q5           Cl       Pri            G3                                       Q1           Cl       COMe           G3                                       Q26          Cl       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Cl       CF.sub.3       G3                                       Q5           Cl       Ph             G3                                       Q26          Cl       Cl             G3                                       Q5           Cl       Br             G3                                       Q2           Cl       Cl             G3                                       Q9           Cl       Ph             G3                                       Q5           Cl       NO.sub.2       G3                                       Q5           Cl       NH.sub.2       G3                                       Q5           Cl       NHMe           G3                                       Q26          Cl       NMe.sub.2      G3                                       Q61          Cl       NHCOMe         G3                                       Q158         Cl       NHSO.sub.2 Me  G3                                       Q2           Cl       NHCOMe         G3                                       Q26          Cl       SO.sub.2 Me    G3                                       Q61          Cl       SO.sub.2 Me    G3                                       Q5           Cl       SO.sub.2 Ph    G3                                       Q61          Cl       SO.sub.2 NH.sub.2                                                                            G3                                       Q5           Cl       SO.sub.2 NHMe  G3                                       Q26          Cl       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           Br       COOMe          G3                                       Q26          Br       COOMe          G3                                       Q61          Br       COOMe          G3                                       Q5           Br       COOEt          G3                                       Q26          Br       COOEt          G3                                       Q61          Br       COOEt          G3                                       Q61          Br       COOPri         G3                                       Q5           Br       COMe           G3                                       Q158         Br       COEt           G3                                       Q26          Br       CN             G3                                       Q26          Br       Me             G3                                       Q158         Br       Et             G3                                       Q26          Br       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Br       CF.sub.3       G3                                       Q5           Br       Ph             G3                                       Q26          Br       Cl             G3                                       Q5           Br       Br             G3                                       Q5           Br       NO.sub.2       G3                                       Q5           Br       NH.sub.2       G3                                       Q26          Br       NMe.sub.2      G3                                       Q61          Br       NHCOMe         G3                                       Q61          Br       SO.sub.2 Me    G3                                       Q5           Br       SO.sub.2 Ph    G3                                       Q61          Br       SO.sub.2 NH.sub.2                                                                            G3                                       Q26          Br       SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           SMe      COOMe          G3                                       Q26          SMe      COOMe          G3                                       Q61          SMe      COOMe          G3                                       Q5           SMe      COOEt          G3                                       Q26          SMe      COOEt          G3                                       Q61          SMe      COOEt          G3                                       Q61          SMe      COOPri         G3                                       Q5           SMe      COMe           G3                                       Q158         SMe      COEt           G3                                       Q26          SMe      CN             G3                                       Q26          SMe      Me             G3                                       Q158         SMe      Et             G3                                       Q26          SMe      CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         SMe      CF.sub.3       G3                                       Q5           SMe      Ph             G3                                       Q26          SMe      Cl             G3                                       Q5           SMe      Br             G3                                       Q5           SMe      NO.sub.2       G3                                       Q5           SMe      NH.sub.2       G3                                       Q26          SMe      NMe.sub.2      G3                                       Q61          SMe      NHCOMe         G3                                       Q61          SMe      SO.sub.2 Me    G3                                       Q5           SMe      SO.sub.2 Ph    G3                                       Q61          SMe      SO.sub.2 NH.sub.2                                                                            G3                                       Q26          SMe      SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           SO.sub. 2 Me                                                                           COOMe          G3                                       Q26          SO.sub.2 Me                                                                            COOMe          G3                                       Q61          SO.sub.2 Me                                                                            COOMe          G3                                       Q5           SO.sub.2 Me                                                                            COOEt          G3                                       Q26          SO.sub.2 Me                                                                            COOEt          G3                                       Q61          SO.sub.2 Me                                                                            COOEt          G3                                       Q96          SO.sub.2 Me                                                                            COOEt          G3                                       Q158         SO.sub.2 Me                                                                            COOEt          G3                                       Q61          SO.sub.2 Me                                                                            COOPri         G3                                       Q5           SO.sub.2 Me                                                                            COMe           G3                                       Q158         SO.sub.2 Me                                                                            COEt           G3                                       Q5           SO.sub.2 Me                                                                            COPri          G3                                       Q26          SO.sub.2 Me                                                                            CN             G3                                       Q61          SO.sub.2 Me                                                                            H              G3                                       Q26          SO.sub.2 Me                                                                            Me             G3                                       Q158         SO.sub.2 Me                                                                            Et             G3                                       Q5           SO.sub.2 Me                                                                            Pri            G3                                       Q1           SO.sub.2 Me                                                                            COMe           G3                                       Q26          SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         SO.sub.2 Me                                                                            CF.sub.3       G3                                       Q5           SO.sub.2 Me                                                                            Ph             G3                                       Q26          SO.sub.2 Me                                                                            Cl             G3                                       Q5           SO.sub.2 Me                                                                            Br             G3                                       Q2           SO.sub.2 Me                                                                            Cl             G3                                       Q9           SO.sub.2 Me                                                                            Ph             G3                                       Q5           SO.sub.2 Me                                                                            NO.sub.2       G3                                       Q5           SO.sub.2 Me                                                                            NH.sub.2       G3                                       Q5           SO.sub.2 Me                                                                            NHMe           G3                                       Q26          SO.sub.2 Me                                                                            NMe.sub.2      G3                                       Q61          SO.sub.2 Me                                                                            NHCOMe         G3                                       Q158         SO.sub.2 Me                                                                            NHSO.sub.2 Me  G3                                       Q2           SO.sub.2 Me                                                                            NHCOMe         G3                                       Q26          SO.sub.2 Me                                                                            SO.sub.2 Me    G3                                       Q61          SO.sub.2 Me                                                                            SO.sub.2 Me    G3                                       Q5           SO.sub.2 Me                                                                            SO.sub.2 Ph    G3                                       Q61          SO.sub.2 Me                                                                            SO.sub.2 NH.sub.2                                                                            G3                                       Q5           SO.sub.2 Me                                                                            SO.sub.2 NHMe  G3                                       Q26          SO.sub.2 Me                                                                            SO.sub.2 NMe.sub.2                                                                           G3                                       Q5           Ph       COOMe          G3                                       Q26          Ph       COOMe          G3                                       Q61          Ph       COOMe          G3                                       Q5           Ph       COOEt          G3                                       Q26          Ph       COOEt          G3                                       Q61          Ph       COOEt          G3                                       Q61          Ph       COOPri         G3                                       Q5           Ph       COMe           G3                                       Q158         Ph       COEt           G3                                       Q26          Ph       CN             G3                                       Q26          Ph       Me             G3                                       Q158         Ph       Et             G3                                       Q26          Ph       CH.sub.2 CH.sub.2 Cl                                                                         G3                                       Q158         Ph       CF.sub.3       G3                                       Q5           Ph       Ph             G3                                       Q26          Ph       Cl             G3                                       Q5           Ph       Br             G3                                       Q5           Ph       NO.sub.2       G3                                       Q5           Ph       NH.sub.2       G3                                       Q26          Ph       NMe.sub.2      G3                                       Q61          Ph       NHCOMe         G3                                       Q61          Ph       SO.sub.2 Me    G3                                       Q5           Ph       SO.sub.2 Ph    G3                                       Q61          Ph       SO.sub.2 NH.sub.2                                                                            G3                                       Q26          Ph       SO.sub.2 NMe.sub.2                                                                           G3                                       Q201         H        COOMe          Ga                                       CH.sub.2 - Q201                                                                            H        COOMe          Gb                                       CHMe - Q201  H        COOMe          Gb                                       Q202         H        COOMe          Gb                                       CH.sub.2 - Q202                                                                            H        COOMe          Gb                                       Q203         H        COOMe          Gb                                       Q204         H        COOMe          Gb                                       Q205         H        COOMe          Gb                                       CH.sub.2 - Q205                                                                            H        COOMe          Gc                                       Q206         H        COOMe          G.sub.3                                  Q207         H        COOMe          Gc                                       Q208         H        COOMe          G.sub.3                                  Q209         H        COOMe          Gc                                       CH.sub.2 - Q209                                                                            H        COOMe          Gc                                       Q210         H        COOMe          Gc                                       CH.sub.2 - Q210                                                                            H        COOMe          G.sub.3                                  Q211         H        COOMe          G.sub.3                                  Q212         H        COOMe          Gc                                       Q213         H        COOMe          Gc                                       Q214         H        COOMe          Gc                                       Q215         H        COOMe          G.sub.1                                  Q216         H        COOMe          Gc                                       Q217         H        COOMe          Gc                                       Q218         H        COOMe          G.sub.3                                  Q219         H        COOMe          Gc                                       Q220         H        COOMe          Gc                                       Q221         H        COOMe          G.sub.2                                  Q222         H        COOMe          Gb                                       CH.sub.2 - Q222                                                                            H        COOMe          Gc                                       Q223         H        COOMe          Gc                                       Q224         H        COOMe          G.sub.3                                  Q225         H        COOMe          Gb                                       CH.sub.2 - Q225                                                                            H        COOMe          Gc                                       Q226         H        COOMe          G.sub.3                                  Q227         H        COOMe          Gc                                       Q228         H        COOMe          Gc                                       Q229         H        COOMe          Gb                                       CH.sub.2 - Q229                                                                            H        COOMe          Gc                                       Q230         H        COOMe          Gc                                       Q231         H        COOMe          Gc                                       Q232         H        COOMe          G.sub.3                                  Q233         H        COOMe          Gc                                       Q234         H        COOMe          Gc                                       Q235         H        COOMe          Gc                                       Q236         H        COOMe          G.sub.3                                  Q237         H        COOMe          Gc                                       Q238         H        COOMe          Gc                                       Q239         H        COOMe          G.sub.2                                  Q240         H        COOMe          Gc                                       Q241         H        COOMe          Gc                                       Q242         H        COOMe          Gc                                       Q243         H        COOMe          G.sub.1                                  Q244         H        COOMe          Gc                                       Q245         H        COOMe          Gc                                       Q246         H        COOMe          Gb                                       CH.sub.2 - Q246                                                                            H        COOMe          Gc                                       Q247         H        COOMe          G.sub.3                                  Q248         H        COOMe          Gc                                       Q249         H        COOMe          Gc                                       Q250         H        COOMe          Gc                                       CH.sub.2 - Q250                                                                            H        COOMe          G.sub.3                                  Q251         H        COOMe          Gc                                       Q252         H        COOMe          Gc                                       Q253         H        COOMe          Gc                                       Q254         H        COOMe          G.sub.1                                  Q255         H        COOMe          Gc                                       Q256         H        COOMe          Gc                                       Q257         H        COOMe          G.sub.3                                  Q258         H        COOMe          Gc                                       Q259         H        COOMe          Gc                                       CH.sub.2 - Q259                                                                            H        COOMe          Gc                                       Q260         H        COOMe          Gc                                       CH.sub.2 - Q260                                                                            H        COOMe          Gc                                       Q261         H        COOMe          G.sub.1                                  Q262         H        COOMe          Gc                                       Q263         H        COOMe          Gc                                       Q264         H        COOMe          G.sub.2                                  Q201         H        COOEt          Ga                                       CH.sub.2 - Q201                                                                            H        COOEt          Gb                                       CHMe - Q201  H        COOEt          Gb                                       Q202         H        COOEt          Gb                                       CH.sub.2 - Q202                                                                            H        COOEt          Gb                                       Q203         H        COOEt          Gb                                       Q204         H        COOEt          Gb                                       Q205         H        COOEt          Gb                                       CH.sub.2 - Q205                                                                            H        COOEt          Gc                                       Q206         H        COOEt          G.sub.3                                  Q207         H        COOEt          Gc                                       Q208         H        COOEt          G.sub.3                                  Q209         H        COOEt          Gc                                       CH.sub.2 - Q209                                                                            H        COOEt          Gc                                       Q210         H        COOEt          Gc                                       CH.sub.2 - 210                                                                             H        COOEt          G.sub.3                                  Q211         H        COOEt          Gc                                       Q212         H        COOEt          Gc                                       Q213         H        COOEt          Gc                                       Q214         H        COOEt          G.sub.1                                  Q215         H        COOEt          Gc                                       Q216         H        COOEt          Gc                                       Q217         H        COOEt          G.sub.2                                  Q218         H        COOEt          Gc                                       Q219         H        COOEt          Gc                                       Q220         H        COOEt          G.sub.3                                  Q221         H        COOEt          Gc                                       Q222         H        COOEt          Gb                                       CH.sub.2 - Q222                                                                            H        COOEt          Gc                                       Q223         H        COOEt          Gc                                       Q224         H        COOEt          Gc                                       Q225         H        COOEt          Gb                                       CH.sub.2 - Q225                                                                            H        COOEt          Gc                                       Q226         H        COOEt          G.sub.3                                  Q227         H        COOEt          Gc                                       Q228         H        COOEt          Gc                                       Q229         H        COOEt          Gb                                       CH.sub.2 - Q229                                                                            H        COOEt          Gc                                       Q230         H        COOEt          Gc                                       Q231         H        COOEt          Gc                                       Q232         H        COOEt          G.sub.3                                  Q233         H        COOEt          Gc                                       Q234         H        COOEt          Gc                                       CH.sub.2 - Q234                                                                            H        COOEt          Gc                                       Q235         H        COOEt          Gc                                       Q236         H        COOEt          G.sub.3                                  Q237         H        COOEt          Gc                                       Q238         H        COOEt          Gc                                       Q239         H        COOEt          Gc                                       Q240         H        COOEt          G.sub.1                                  Q241         H        COOEt          Gc                                       Q242         H        COOEt          Gc                                       Q243         H        COOEt          Gc                                       Q244         H        COOEt          G.sub.2                                  Q245         H        COOEt          Gc                                       Q246         H        COOEt          Gb                                       CH.sub.2 - Q246                                                                            H        COOEt          Gc                                       Q247         H        COOEt          Gc                                       Q248         H        COOEt          Gc                                       Q249         H        COOEt          G.sub.3                                  Q250         H        COOEt          Gc                                       CH.sub.2 - Q250                                                                            H        COOEt          Gc                                       Q251         H        COOEt          Gc                                       Q252         H        COOEt          G.sub.3                                  Q253         H        COOEt          Gc                                       Q254         H        COOEt          Gc                                       Q255         H        COOEt          Gc                                       Q256         H        COOEt          Gc                                       Q257         H        COOEt          Gc                                       Q258         H        COOEt          G.sub.1                                  Q259         H        COOEt          Gc                                       CH.sub.2 - Q259                                                                            H        COOEt          Gc                                       Q260         H        COOEt          Gc                                       CH.sub.2 - Q260                                                                            H        COOEt          Gc                                       Q261         H        COOEt          G.sub.3                                  Q262         H        COOEt          Gc                                       Q263         H        COOEt          Gc                                       Q264         H        COOEt          G.sub.3                                  Q201         H        COOH           Gc                                       Q202         H        COOH           Gc                                       Q222         H        COOH           Gc                                       Q225         H        COOH           G.sub.3                                  Q229         H        COOH           Gc                                       Q246         H        COOH           G.sub.3                                  Q201         H        COOPri         Gc                                       Q202         H        COOPri         G.sub.3                                  Q205         H        COOPri         Gc                                       Q209         H        COOPri         Gc                                       Q222         H        COOPri         Gc                                       Q225         H        COOPri         Gc                                       Q229         H        COOPri         G.sub.3                                  Q246         H        COOPri         Gc                                       Q201         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q202         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q205         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q209         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q222         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q225         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q229         H        COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q246         H        COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.1                                  Q201         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q202         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q205         H        COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q209         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q222         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q225         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q229         H        COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q246         H        COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         H        COOCH.sub.2 CCH                                                                              Gc                                       Q202         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q205         H        COOCH.sub.2 CCH                                                                              Gc                                       Q209         H        COOCH.sub.2 CCH                                                                              Gc                                       Q222         H        COOCH.sub. 2 CCH                                                                             Gc                                       Q225         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q229         H        COOCH.sub.2 CCH                                                                              Gc                                       Q246         H        COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         H        CONHMe         Gc                                       Q202         H        CONHMe         G.sub.3                                  Q205         H        CONHMe         Gc                                       Q209         H        CONHMe         Gc                                       Q222         H        CONHMe         G.sub.3                                  Q225         H        CONHMe         Gc                                       Q229         H        CONHMe         Gc                                       Q246         H        CONHMe         G.sub.3                                  Q201         H        CONMe.sub.2    Gc                                       Q202         H        CONMe.sub.2    G.sub.3                                  Q205         H        CONMe.sub.2    Gc                                       Q209         H        CONMe.sub.2    Gc                                       Q222         H        CONMe.sub.2    Gc                                       Q225         H        COMe           Gc                                       Q229         H        COMe           Gc                                       Q230         H        COMe           G.sub.2                                  Q231         H        COMe           G.sub.3                                  Q237         H        COMe           Gc                                       Q246         H        COMe           Gc                                       Q247         H        COMe           G.sub.3                                  Q250         H        COMe           Gc                                       Q259         H        COMe           Gc                                       Q260         H        COMe           Gc                                       Q263         H        COMe           G.sub.3                                  Q201         H        COEt           Gc                                       Q202         H        COEt           G.sub.3                                  Q205         H        COEt           Gc                                       Q209         H        COEt           Gc                                       Q222         H        COEt           Gc                                       Q225         H        COEt           G.sub.3                                  Q229         H        COEt           Gc                                       Q246         H        COEt           G.sub.3                                  Q201         H        COPri          Gc                                       Q202         H        COPri          G.sub.3                                  Q205         H        COPri          Gc                                       Q209         H        COPri          Gc                                       Q222         H        COPri          Gc                                       Q225         H        COPri          G.sub.3                                  Q229         H        COPri          Gc                                       Q246         H        COPri          Gc                                       Q201         H        COPh           Gc                                       Q202         H        COPh           G.sub.3                                  Q205         H        COPh           Gc                                       Q209         H        COPh           Gc                                       Q222         H        COPh           G.sub.3                                  Q225         H        COPh           Gc                                       Q229         H        COPh           Gc                                       Q246         H        COPh           G.sub.3                                  Q201         H        CN             Gc                                       CH.sub.2 - Q201                                                                            H        CN             G.sub.3                                  Q202         H        CN             Gc                                       Q205         H        CN             Gc                                       Q209         H        CN             Gc                                       Q222         H        CN             Gc                                       Q225         H        CN             Gc                                       Q229         H        CN             Gc                                       Q246         H        CN             G.sub.3                                  Q201         H        H              Gc                                       Q202         H        H              G.sub.3                                  Q205         H        H              Gc                                       Q207         H        H              Gc                                       Q222         H        H              Gc                                       Q225         H        H              G.sub.3                                  Q229         H        H              Gc                                       Q230         H        H              Gc                                       Q231         H        H              G.sub.3                                  Q237         H        H              Gc                                       Q246         H        H              Gc                                       Q247         H        H              G.sub.3                                  Q250         H        H              Gc                                       Q259         H        H              G.sub.3                                  Q260         H        H              Gc                                       Q263         H        H              G.sub.3                                  Q201         H        Me             Gc                                       Q202         H        Me             G.sub.3                                  Q205         H        Me             Gc                                       Q207         H        Me             G.sub.3                                  Q222         H        Me             Gc                                       Q225         H        Me             Gc                                       Q229         H        Me             Gc                                       Q230         H        Me             G.sub.3                                  Q231         H        Me             Gc                                       Q237         H        Me             Gc                                       Q246         H        Me             Gc                                       Q247         H        Me             G.sub.3                                  Q250         H        Me             Gc                                       Q259         H        Me             Gc                                       Q260         H        Me             Gc                                       Q263         H        Me             G.sub.3                                  Q201         H        Et             Gc                                       Q202         H        Et             G.sub.1                                  Q205         H        Et             Gc                                       Q209         H        Et             Gc                                       Q222         H        Et             G.sub.3                                  Q225         H        Et             Gc                                       Q229         H        Et             Gc                                       Q246         H        Et             G.sub.2                                  Q201         H        Pri            Gc                                       Q205         H        Pri            Gc                                       Q209         H        Pri            Gc                                       Q222         H        Pri            G.sub.3                                  Q229         H        Pri            Gc                                       Q201         H        CHCH.sub.2     Gc                                       Q205         H        CHCH.sub.2     G.sub.3                                  Q209         H        CHCH.sub.2     Gc                                       Q229         H        CHCH.sub.2     G.sub.3                                  Q201         H        CHCHMe         Gc                                       Q205         H        CHCHMe         Gc                                       Q201         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q205         H        CH.sub.2 CHCH.sub.2                                                                          G.sub.3                                  Q209         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q229         H        CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q201         H        CH.sub.2 Cl    Gc                                       Q205         H        CH.sub.2 Cl    G.sub.3                                  Q209         H        CH.sub.2 Cl    Gc                                       Q229         H        CH.sub.2 Cl    Gc                                       Q201         H        CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         H        CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q209         H        CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q229         H        CH.sub.2 CH.sub.2 Cl                                                                         G.sub.2                                  Q201         H        CF.sub.3       Gc                                       Q205         H        CF.sub.3       G.sub.3                                  Q209         H        CF.sub.3       Gc                                       Q222         H        CF.sub.3       Gc                                       Q225         H        CF.sub.3       G.sub.3                                  Q229         H        CF.sub.3       G.sub.1                                  Q201         H        CFCFCl         Gc                                       Q205         H        CFCFCl         Gc                                       Q229         H        CFCFCl         G.sub.3                                  Q201         H        CH.sub.2 Ph    Gc                                       Q205         H        CH.sub.2 Ph    Gc                                       Q209         H        CH.sub.2 Ph    G.sub.3                                  Q201         H        Ph             Gc                                       Q202         H        Ph             G.sub.1                                  Q205         H        Ph             Gc                                       Q209         H        Ph             Gc                                       Q222         H        Ph             G.sub.3                                  Q225         H        Ph             Gc                                       Q229         H        Ph             Gc                                       Q246         H        Ph             G.sub.2                                  Q201         H        Ph2-Cl         Gc                                       Q205         H        Ph2-Cl         G.sub.1                                  Q209         H        Ph2-Cl         Gc                                       Q201         H        Ph2-Me         Gc                                       Q205         H        Ph2-Me         G.sub.3                                  Q209         H        Ph2-Me         Gc                                       Q225         H        Ph2-Me         Gc                                       Q229         H        Ph2-Me         G.sub.3                                  Q201         H        Cl             Gc                                       Q205         H        Cl             Gc                                       Q207         H        Cl             G.sub.3                                  Q222         H        Cl             Gc                                       Q225         H        Cl             Gc                                       Q229         H        Cl             G.sub.1                                  Q231         H        Cl             Gc                                       Q246         H        Cl             Gc                                       Q250         H        Cl             G.sub.3                                  Q259         H        Cl             Gc                                       Q260         H        Cl             Gc                                       Q201         H        Br             Gc                                       Q205         H        Br             G.sub.3                                  Q207         H        Br             Gc                                       Q229         H        Br             Gc                                       Q231         H        Br             G.sub.3                                  Q250         H        Br             Gc                                       Q259         H        Br             Gc                                       Q260         H        Br             G.sub.3                                  Q201         H        F              Gc                                       Q205         H        F              G.sub.3                                  Q209         H        F              Gc                                       Q229         H        F              Gc                                       Q246         H        F              G.sub.3                                  Q201         H        I              Gc                                       Q205         H        I              Gc                                       Q209         H        I              Gc                                       Q222         H        I              Gc                                       Q201         H        NO.sub.2       Gc                                       CH.sub.2 - Q201                                                                            H        NO.sub.2       G.sub.3                                  Q202         H        NO.sub.2       G.sub.3                                  Q205         H        NO.sub.2       Gc                                       Q207         H        NO.sub.2       Gc                                       Q222         H        NO.sub.2       G.sub.3                                  Q225         H        NO.sub.2       Gc                                       Q229         H        NO.sub.2       Gc                                       Q230         H        NO.sub.2       G.sub.1                                  Q231         H        NO.sub.2       Gc                                       Q237         H        NO.sub.2       Gc                                       Q246         H        NO.sub.2       Gc                                       Q247         H        NO.sub.2       G.sub.2                                  Q250         H        NO.sub.2       Gc                                       Q259         H        NO.sub.2       Gc                                       Q260         H        NO.sub.2       G.sub.3                                  Q263         H        NO.sub.2       Gc                                       Q201         H        NH.sub.2       Gc                                       Q202         H        NH.sub.2       G.sub.3                                  Q205         H        NH.sub.2       Gc                                       Q209         H        NH.sub.2       Gc                                       Q222         H        NH.sub.2       G.sub.3                                  Q225         H        NH.sub.2       Gc                                       Q229         H        NH.sub.2       Gc                                       Q246         H        NH.sub.2       G.sub.3                                  Q201         H        NHMe           Gc                                       Q205         H        NHMe           Gc                                       Q209         H        NHMe           Gc                                       Q225         H        NHMe           Gc                                       Q229         H        NHMe           G.sub.3                                  Q201         H        NMe.sub.2      Gc                                       Q205         H        NMe.sub.2      Gc                                       Q209         H        NMe.sub.2      Gc                                       Q222         H        NMe.sub.2      G.sub.1                                  Q225         H        NMe.sub.2      Gc                                       Q229         H        NMe.sub.2      Gc                                       Q246         H        NMe.sub.2      G.sub.3                                  Q201         H        NMeEt          Gc                                       Q205         H        NMeEt          Gc                                       Q209         H        NMeEt          G.sub.3                                  Q222         H        NMeEt          Gc                                       Q225         H        NMeEt          Gc                                       Q229         H        NMeEt          G.sub.2                                  Q201         H        NHCOMe         Gc                                       Q202         H        NHCOMe         G.sub.3                                  Q205         H        NHCOMe         Gc                                       Q209         H        NHCOMe         Gc                                       Q222         H        NHCOMe         G.sub.3                                  Q225         H        NHCOMe         Gc                                       Q229         H        NHCOMe         Gc                                       Q246         H        NHCOMe         G.sub.3                                  Q201         H        NHCOEt         Gc                                       Q205         H        NHCOEt         Gc                                       Q209         H        NHCOEt         Gc                                       Q222         H        NHCOEt         G.sub.1                                  Q225         H        NHCOEt         Gc                                       Q229         H        NHCOEt         G.sub.3                                  Q201         H        NHSO.sub.2 Me  Gc                                       Q205         H        NHSO.sub.2 Me  Gc                                       Q209         H        NHSO.sub.2 Me  Gc                                       Q225         H        NHSO.sub.2 Me  G.sub.3                                  Q229         H        NHSO.sub.2 Me  G.sub.3                                  Q201         H        OMe            Gc                                       Q205         H        OMe            Gc                                       Q209         H        OMe            G.sub.3                                  Q222         H        OMe            Gc                                       Q225         H        OMe            Gc                                       Q229         H        OMe            G.sub.2                                  Q246         H        OMe            G.sub.1                                  Q201         H        OEt            Gc                                       Q205         H        OEt            Gc                                       Q209         H        OEt            Gc                                       Q222         H        OEt            G.sub.3                                  Q229         H        OEt            Gc                                       Q201         H        CH.sub.2 OMe   Gc                                       Q205         H        CH.sub.2 OMe   Gc                                       Q209         H        CH.sub.2 OMe   G.sub.3                                  Q222         H        CH.sub.2 OMe   Gc                                       Q201         H        SMe            Gc                                       Q205         H        SMe            Gc                                       Q209         H        SMe            Gc                                       Q222         H        SMe            G.sub.1                                  Q225         H        SMe            Gc                                       Q229         H        SMe            G.sub.3                                  Q201         H        SO.sub.2 Me    Gc                                       CH.sub.2 - Q201                                                                            H        SO.sub.2 Me    G.sub.3                                  Q202         H        SO.sub.2 Me    Gc                                       Q205         H        SO.sub.2 Me    Gc                                       Q209         H        SO.sub.2 Me    Gc                                       Q222         H        SO.sub.2 Me    G.sub.3                                  Q225         H        SO.sub.2 Me    Gc                                       Q229         H        SO.sub.2 Me    Gc                                       Q246         H        SO.sub.2 Me    G.sub.3                                  Q201         H        SO.sub.2 Ph    Gc                                       Q202         H        SO.sub.2 Ph    G.sub.1                                  Q205         H        SO.sub.2 Ph    Gc                                       Q209         H        SO.sub.2 Ph    Gc                                       Q222         H        SO.sub.2 Ph    Gc                                       Q225         H        SO.sub.2 Ph    G.sub.3                                  Q229         H        SO.sub.2 Ph    Gc                                       Q246         H        SO.sub.2 Ph    G.sub.1                                  Q201         H        SO.sub.2 OMe   Gc                                       Q205         H        SO.sub.2 OMe   Gc                                       Q209         H        SO.sub.2 OMe   Gc                                       Q222         H        SO.sub.2 OMe   Gc                                       Q229         H        SO.sub.2 OMe   G.sub.3                                  Q201         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q209         H        SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q225         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q229         H        SO.sub.2 NH.sub.2                                                                            Gc                                       Q246         H        SO.sub.2 NH.sub.2                                                                            G.sub.1                                  Q201         H        SO.sub.2 NHMe  Gc                                       Q205         H        SO.sub.2 NHMe  Gc                                       Q209         H        SO.sub.2 NHMe  G.sub.3                                  Q222         H        SO.sub.2 NHMe  Gc                                       Q225         H        SO.sub.2 NHMe  Gc                                       Q229         H        SO.sub.2 NHMe  Gc                                       Q246         H        SO.sub.2 NHMe  G.sub.2                                  Q201         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q202         H        SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q205         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q209         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q222         H        SO.sub.2 NMe.sub.2                                                                           G.sub.2                                  Q225         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q229         H        SO.sub.2 NMe.sub.2                                                                           Gc                                       Q246         H        SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         Me       COOMe          Gc                                       CH.sub.2 - Q201                                                                            Me       COOMe          G.sub.3                                  Q202         Me       COOMe          G.sub.1                                  Q205         Me       COOMe          Gc                                       Q207         Me       COOMe          G.sub.3                                  Q209         Me       COOMe          Gc                                       Q222         Me       COOMe          Gc                                       Q225         Me       COOMe          G.sub.2                                  Q229         Me       COOMe          Gc                                       Q230         Me       COOMe          Gc                                       Q231         Me       COOMe          G.sub.3                                  Q237         Me       COOMe          Gc                                       Q246         Me       COOMe          Gc                                       Q247         Me       COOMe          G.sub.3                                  Q250         Me       COOMe          Gc                                       Q259         Me       COOMe          G.sub.1                                  Q260         Me       COOMe          Gc                                       Q263         Me       COOMe          G.sub.3                                  Q201         Me       COOEt          Gc                                       CH.sub.2 - Q201                                                                            Me       COOEt          G.sub.2                                  Q222         Me       COOEt          Gc                                       Q205         Me       COOEt          Gc                                       Q207         Me       COOEt          G.sub.3                                  Q209         Me       COOEt          Gc                                       Q222         Me       COOEt          Gc                                       Q225         Me       COOEt          G.sub.3                                  Q229         Me       COOEt          Gc                                       Q230         Me       COOEt          Gc                                       Q231         Me       COOEt          Gc                                       Q237         Me       COOEt          G.sub.1                                  Q246         Me       COOEt          Gc                                       Q247         Me       COOEt          Gc                                       Q250         Me       COOEt          Gc                                       Q259         Me       COOEt          G.sub.3                                  Q260         Me       COOEt          Gc                                       Q263         Me       COOEt          G.sub.3                                  Q201         Me       COOH           G.sub.1                                  Q205         Me       COOH           Gc                                       Q201         Me       COOPri         Gc                                       Q202         Me       COOPri         G.sub.3                                  Q205         Me       COOPri         Gc                                       Q209         Me       COOPri         Gc                                       Q222         Me       COOPri         G.sub.3                                  Q225         Me       COOPri         Gc                                       Q229         Me       COOPri         Gc                                       Q246         Me       COOPri         G.sub.1                                  Q201         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q205         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q222         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q229         Me       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.1                                  Q201         Me       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q205         Me       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q222         Me       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q229         Me       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.1                                  Q201         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q205         Me       COOCH.sub.2 CCH                                                                              G.sub.2                                  Q222         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q229         Me       COOCH.sub.2 CCH                                                                              Gc                                       Q201         Me       CONHMe         Gc                                       Q205         Me       CONHMe         G.sub.3                                  Q222         Me       CONHMe         Gc                                       Q229         Me       CONHMe         Gc                                       Q201         Me       CONMe.sub.2    Gc                                       Q205         Me       CONMe.sub.2    G.sub.3                                  Q222         Me       CONMe.sub.2    Gc                                       Q229         Me       CONMe.sub.2    Gc                                       Q201         Me       COMe           Gc                                       Q202         Me       COMe           G.sub.3                                  Q205         Me       COMe           Gc                                       Q207         Me       COMe           Gc                                       Q222         Me       COMe           G.sub.3                                  Q225         Me       COMe           Gc                                       Q229         Me       COMe           Gc                                       Q230         Me       COMe           G.sub.3                                  Q231         Me       COMe           Gc                                       Q237         Me       COMe           Gc                                       Q246         Me       COMe           Gc                                       Q247         Me       COMe           G.sub.2                                  Q250         Me       COMe           Gc                                       Q259         Me       COMe           Gc                                       Q260         Me       COMe           G.sub.1                                  Q263         Me       COMe           Gc                                       Q201         Me       COEt           Gc                                       Q205         Me       COEt           G.sub.3                                  Q222         Me       COEt           Gc                                       Q229         Me       COEt           Gc                                       Q201         Me       COPri          Gc                                       Q205         Me       COPri          G.sub.3                                  Q222         Me       COPri          Gc                                       Q229         Me       COPri          G.sub.1                                  Q201         Me       COPh           Gc                                       Q205         Me       COPh           Gc                                       Q222         Me       COPh           G.sub.3                                  Q229         Me       COPh           Gc                                       Q201         Me       CN             Gc                                       Q202         Me       CN             G.sub.3                                  Q205         Me       CN             Gc                                       Q209         Me       CN             Gc                                       Q222         Me       CN             G.sub.3                                  Q225         Me       CN             Gc                                       Q229         Me       CN             Gc                                       Q246         Me       CN             G.sub.1                                  Q201         Me       H              Gc                                       Q205         Me       H              Gc                                       Q222         Me       H              G.sub.3                                  Q229         Me       H              Gc                                       Q201         Me       Me             Gc                                       Q202         Me       Me             G.sub.3                                  Q205         Me       Me             Gc                                       Q209         Me       Me             Gc                                       Q222         Me       Me             Gc                                       Q225         Me       Me             Gc                                       Q229         Me       Me             G.sub.3                                  Q246         Me       Me             Gc                                       Q201         Me       Et             Gc                                       Q205         Me       Et             Gc                                       Q222         Me       Et             G.sub.3                                  Q229         Me       Et             Gc                                       Q201         Me       Pri            Gc                                       Q205         Me       Pri            G.sub.2                                  Q201         Me       CHCH.sub.2     Gc                                       Q205         Me       CHCH.sub.2     G.sub.3                                  Q201         Me       CHCHMe         G.sub.3                                  Q205         Me       CHCHMe         Gc                                       Q201         Me       CH.sub.2 CHCH.sub.2                                                                          Gc                                       Q205         Me       CH.sub.2 CHCH.sub.2                                                                          G.sub.3                                  Q201         Me       CH.sub.2 Cl    Gc                                       Q205         Me       CH.sub.2 Cl    G.sub.2                                  Q222         Me       CH.sub.2 Cl    Gc                                       Q229         Me       CH.sub.2 Cl    G.sub.3                                  Q201         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q222         Me       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q229         Me       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Me       CF.sub.3       Gc                                       Q205         Me       CF.sub.3       G.sub.3                                  Q222         Me       CF.sub.3       G.sub.3                                  Q229         Me       CF.sub.3       Gc                                       Q201         Me       CFCFCl         Gc                                       Q205         Me       CFCFCl         G.sub.3                                  Q201         Me       CH.sub.2 Ph    Gc                                       Q205         Me       CH.sub.2 Ph    G.sub.3                                  Q201         Me       Ph             Gc                                       Q202         Me       Ph             Gc                                       Q205         Me       Ph             Gc                                       Q209         Me       Ph             Gc                                       Q222         Me       Ph             G.sub.3                                  Q225         Me       Ph             G.sub.3                                  Q229         Me       Ph             Gc                                       Q246         Me       Ph             G.sub.3                                  Q201         Me       Ph2-Cl         Gc                                       Q205         Me       Ph2-Cl         G.sub.3                                  Q201         Me       Ph2-Me         Gc                                       Q205         Me       Ph2-Me         Gc                                       Q229         Me       Ph2-Me         G.sub.3                                  Q201         Me       Cl             Gc                                       Q202         Me       Cl             G.sub.3                                  Q205         Me       Cl             Gc                                       Q209         Me       Cl             Gc                                       Q222         Me       Cl             G.sub.3                                  Q225         Me       Cl             Gc                                       Q229         Me       Cl             Gc                                       Q246         Me       Cl             G.sub.3                                  Q201         Me       Br             Gc                                       Q205         Me       Br             G.sub.3                                  Q222         Me       Br             Gc                                       Q229         Me       Br             G.sub.1                                  Q201         Me       F              G.sub.1                                  Q205         Me       F              G.sub.1                                  Q201         Me       I              G.sub.1                                  Q205         Me       I              G.sub.1                                  Q201         Me       NO.sub.2       Gc                                       Q202         Me       NO.sub.2       G.sub.3                                  Q205         Me       NO.sub.2       Gc                                       Q209         Me       NO.sub.2       Gc                                       Q222         Me       NO.sub.2       Gc                                       Q225         Me       NO.sub.2       G.sub.3                                  Q229         Me       NO.sub.2       Gc                                       Q246         Me       NO.sub.2       Gc                                       Q201         Me       NH.sub.2       Gc                                       Q205         Me       NH.sub.2       G.sub.3                                  Q222         Me       NH.sub.2       Gc                                       Q229         Me       NH.sub.2       G.sub. 3                                 Q201         Me       NHMe           Gc                                       Q205         Me       NHMe           Gc                                       Q229         Me       NHMe           G.sub.3                                  Q201         Me       NMe.sub.2      Gc                                       Q205         Me       NMe.sub.2      Gc                                       Q229         Me       NMe.sub.2      G.sub.3                                  Q201         Me       NMeEt          Gc                                       Q205         Me       NMeEt          Gc                                       Q201         Me       NHCOMe         Gc                                       Q205         Me       NHCOMe         Gc                                       Q222         Me       NHCOMe         G.sub.3                                  Q229         Me       NHCOMe         Gc                                       Q201         Me       NHCOEt         Gc                                       Q205         Me       NHCOEt         G.sub.3                                  Q201         Me       NHSO.sub.2 Me  Gc                                       Q205         Me       NHSO.sub.2 Me  Gc                                       Q229         Me       NHSO.sub.2 Me  G.sub.2                                  Q201         Me       OMe            Gc                                       Q205         Me       OMe            G.sub.3                                  Q222         Me       OMe            Gc                                       Q229         Me       OMe            G.sub.1                                  Q201         Me       OEt            Gc                                       Q205         Me       OEt            G.sub.3                                  Q201         Me       CH.sub.2 OMe   Gc                                       Q205         Me       CH.sub.2 OMe   Gc                                       Q229         Me       CH.sub.2 OMe   G.sub.3                                  Q201         Me       SMe            Gc                                       Q205         Me       SMe            G.sub.3                                  Q201         Me       SO.sub.2 Me    Gc                                       Q205         Me       SO.sub.2 Me    Gc                                       Q222         Me       SO.sub.2 Me    G.sub.1                                  Q229         Me       SO.sub.2 Me    G.sub.3                                  Q201         Me       SO.sub.2 Ph    Gc                                       Q205         Me       SO.sub.2 Ph    Gc                                       Q222         Me       SO.sub.2 Ph    G.sub.3                                  Q229         Me       SO.sub.2 Ph    Gc                                       Q201         Me       SO.sub.2 OMe   Gc                                       Q205         Me       SO.sub.2 OMe   G.sub.3                                  Q229         Me       SO.sub.2 OMe   Gc                                       Q201         Me       SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         Me       SO.sub.2 NH.sub.2                                                                            Gc                                       Q229         Me       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Me       SO.sub.2 NHMe  Gc                                       Q205         Me       SO.sub.2 NHMe  Gc                                       Q222         Me       SO.sub.2 NHMe  G.sub.1                                  Q229         Me       SO.sub.2 NHMe  Gc                                       Q201         Me       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q205         Me       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q222         Me       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q229         Me       SO.sub.2 NMe.sub.2                                                                           G.sub.1                                  Q201         Et       COOMe          Gc                                       Q205         Et       COOMe          Gc                                       Q229         Et       COOMe          G.sub.3                                  Q246         Et       COOMe          G.sub.3                                  Q201         Et       COOEt          Gc                                       Q202         Et       COOEt          G.sub.2                                  Q209         Et       COOEt          Gc                                       Q222         Et       COOEt          G.sub.3                                  Q225         Et       COOEt          Gc                                       Q201         Et       COOPri         G.sub.3                                  Q205         Et       COOPri         Gc                                       Q201         Et       COOCH.sub.2 CHCl                                                                             Gc                                       Q205         Et       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         Et       COOCH.sub.2 CCH                                                                              Gc                                       Q201         Et       CONHMe         Gc                                       Q201         Et       CONMe.sub.2    Gc                                       Q201         Et       COMe           Gc                                       Q205         Et       COMe           G.sub.3                                  Q229         Et       COMe           Gc                                       Q201         Et       COEt           Gc                                       Q201         Et       COPh           Gc                                       Q201         Et       CN             Gc                                       Q205         Et       CN             G.sub.3                                  Q229         Et       CN             Gc                                       Q201         Et       H              Gc                                       Q205         Et       H              G.sub.3                                  Q201         Et       Me             Gc                                       Q205         Et       Me             G.sub.3                                  Q201         Et       Et             Gc                                       Q205         Et       Pri            Gc                                       Q201         Et       CHCHMe         Gc                                       Q201         Et       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Et       CH.sub.2 Ph    G.sub.3                                  Q201         Et       Ph             Gc                                       Q205         Et       Ph             Gc                                       Q209         Et       Ph             Gc                                       Q229         Et       Ph             G.sub.3                                  Q201         Et       Ph2-Cl         Gc                                       Q205         Et       Ph2-Me         Gc                                       Q201         Et       Cl             Gc                                       Q205         Et       Cl             G.sub.2                                  Q201         Et       Br             Gc                                       Q205         Et       Br             G.sub.1                                  Q201         Et       F              Gc                                       Q201         Et       NO.sub.2       Gc                                       Q205         Et       NO.sub.2       G.sub.3                                  Q209         Et       NO.sub.2       Gc                                       Q201         Et       NH.sub.2       Gc                                       Q201         Et       NHMe           Gc                                       Q201         Et       NMe.sub.2      Gc                                       Q205         Et       NMe.sub.2      G.sub.3                                  Q201         Et       NHCOMe         Gc                                       Q205         Et       NHCOMe         Gc                                       Q201         Et       NHCOEt         Gc                                       Q201         Et       NHSO.sub.2 Me  Gc                                       Q201         Et       OMe            Gc                                       Q205         Et       OEt            G.sub.3                                  Q201         Et       CH.sub.2 OMe   Gc                                       Q201         Et       SMe            Gc                                       Q201         Et       SO.sub.2 Me    Gc                                       Q205         Et       SO.sub.2 Me    G.sub.3                                  Q201         Et       SO.sub.2 Ph    Gc                                       Q205         Et       SO.sub.2 Ph    G.sub.3                                  Q201         Et       SO.sub.2 OMe   Gc                                       Q201         Et       SO.sub.2 NH.sub.2                                                                            Gc                                       Q205         Et       SO.sub.2 NHMe  G.sub.3                                  Q201         Et       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q205         Et       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         Cl       COOMe          Gc                                       Q209         Cl       COOMe          G.sub.3                                  Q229         Cl       COOMe          Gc                                       Q246         Cl       COOMe          G.sub.3                                  Q201         Cl       COOEt          Gc                                       Q205         Cl       COOEt          Gc                                       Q222         Cl       COOEt          G.sub.1                                  Q225         Cl       COOEt          Gc                                       Q246         Cl       COOEt          G.sub.3                                  Q201         Cl       COOPri         Gc                                       Q205         Cl       COOPri         G.sub.3                                  Q205         Cl       COOCH.sub.2 CH.sub.2 Cl                                                                      G.sub.3                                  Q201         Cl       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         Cl       COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         Cl       CONHMe         Gc                                       Q201         Cl       CONMe.sub.2    G.sub.3                                  Q201         Cl       COMe           Gc                                       Q205         Cl       COMe           Gc                                       Q201         Cl       COEt           G.sub.3                                  Q201         Cl       COPri          Gc                                       Q201         Cl       COPh           G.sub.3                                  Q201         Cl       CN             Gc                                       Q205         Cl       CN             Gc                                       Q201         Cl       H              G.sub.3                                  Q201         Cl       Me             Gc                                       Q205         Cl       Me             G.sub.3                                  Q205         Cl       Et             Gc                                       Q201         Cl       Pri            G.sub.3                                  Q201         Cl       CHCHMe         Gc                                       Q201         Cl       CH.sub.2 CH CH.sub.2                                                                         G.sub.1                                  Q205         Cl       CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q201         Cl       Ph             Gc                                       Q205         Cl       Ph             Gc                                       Q209         Cl       Ph             G.sub.3                                  Q201         Cl       Ph2-Cl         Gc                                       Q205         Cl       Ph2-Me         G.sub.3                                  Q201         Cl       Cl             Gc                                       Q205         Cl       Cl             G.sub.3                                  Q201         Cl       Br             Gc                                       Q201         Cl       NO.sub.2       Gc                                       Q205         Cl       NO.sub.2       G.sub.3                                  Q209         Cl       NO.sub.2       Gc                                       Q201         Cl       NH.sub.2       Gc                                       Q201         Cl       NHMe           G.sub.1                                  Q201         Cl       NMe.sub.2      G.sub.3                                  Q201         Cl       NHCOMe         Gc                                       Q205         Cl       NHCOEt         Gc                                       Q201         Cl       NHSO.sub.2 Me  G.sub.3                                  Q201         Cl       OMe            Gc                                       Q201         Cl       CH.sub.2 OMe   G.sub.3                                  Q201         Cl       SO.sub.2 Me    Gc                                       Q201         Cl       SO.sub.2 Ph    Gc                                       Q201         Cl       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Cl       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q205         Cl       SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         Br       COOMe          Gc                                       Q205         Br       COOMe          G.sub.3                                  Q209         Br       COOMe          G.sub.3                                  Q201         Br       COOEt          Gc                                       Q209         Br       COOEt          Gc                                       Q229         Br       COOEt          G.sub.3                                  Q201         Br       COOPri         G.sub.3                                  Q201         Br       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         Br       COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         Br       CONHMe         Gc                                       Q201         Br       CONMe.sub.2    G.sub. 3                                 Q201         Br       COMe           Gc                                       Q205         Br       COMe           G.sub.3                                  Q201         Br       COEt           Gc                                       Q201         Br       COPh           G.sub.3                                  Q201         Br       CN             Gc                                       Q205         Br       CN             Gc                                       Q201         Br       H              G.sub.3                                  Q201         Br       Me             G.sub.2                                  Q201         Br       Et             G.sub.1                                  Q201         Br       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         Br       Ph             Gc                                       Q205         Br       Ph             Gc                                       Q209         Br       Ph             G.sub.3                                  Q201         Br       Ph2-Cl         G.sub.3                                  Q201         Br       Cl             Gc                                       Q201         Br       Br             Gc                                       Q205         Br       Br             G.sub.3                                  Q201         Br       NO.sub.2       Gc                                       Q209         Br       NO.sub.2       Gc                                       Q201         Br       NH.sub.2       Gc                                       Q201         Br       NMe.sub.2      G.sub.3                                  Q201         Br       NHCOMe         Gc                                       Q201         Br       OMe            G.sub.3                                  Q201         Br       CH.sub.2 OMe   Gc                                       Q201         Br       SMe            Gc                                       Q201         Br       SO.sub.2 Me    Gc                                       Q201         Br       SO.sub.2 NH.sub.2                                                                            G.sub.3                                  Q201         Br       SO.sub.2 NHMe  Gc                                       Q201         Br       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  Q201         SMe      COOMe          Gc                                       Q205         SMe      COOMe          Gc                                       Q209         SMe      COOMe          G.sub.3                                  Q201         SMe      COOEt          Gc                                       Q205         SMe      COOEt          Gc                                       Q209         SMe      COOEt          Gc                                       Q229         SMe      COOEt          G.sub.3                                  Q246         SMe      COOEt          Gc                                       Q201         SMe      COOPri         Gc                                       Q205         SMe      COOPri         G.sub.3                                  Q201         SMe      COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         SMe      COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         SMe      CONHMe         Gc                                       Q201         SMe      CONMe.sub.2    G.sub.1                                  Q201         SMe      COMe           Gc                                       Q205         SMe      COMe           Gc                                       Q201         SMe      COEt           G.sub.3                                  Q201         SMe      COPri          Gc                                       Q201         SMe      COPh           G.sub.3                                  Q201         SMe      CN             Gc                                       Q205         SMe      CN             Gc                                       Q229         SMe      CN             G.sub.3                                  Q201         SMe      H              Gc                                       Q201         SMe      Me             Gc                                       Q205         SMe      Me             G.sub.3                                  Q201         SMe      Et             Gc                                       Q205         SMe      Et             Gc                                       Q201         SMe      CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         SMe      Ph             Gc                                       Q205         SMe      Ph             Gc                                       Q209         SMe      Ph             G.sub.3                                  Q201         SMe      Ph2-Cl         Gc                                       Q201         SMe      Cl             Gc                                       Q205         SMe      Cl             G.sub.3                                  Q201         SMe      Br             Gc                                       Q201         SMe      NO.sub.2       Gc                                       Q205         SMe      NO.sub.2       Gc                                       Q209         SMe      NO.sub.2       G.sub.3                                  Q201         SMe      NH.sub.2       Gc                                       Q205         SMe      NH.sub.2       Gc                                       Q201         SMe      NHMe           G.sub.3                                  Q201         SMe      NMe.sub.2      Gc                                       Q205         SMe      NMe.sub.2      Gc                                       Q201         SMe      NHCOMe         Gc                                       Q205         SMe      NHCOMe         G.sub.3                                  Q201         SMe      NHSO.sub.2 Me  Gc                                       Q201         SMe      OMe            Gc                                       Q201         SMe      CH.sub.2 OMe   Gc                                       Q201         SMe      SMe            Gc                                       Q201         SMe      SO.sub.2 Me    Gc                                       Q205         SMe      SO.sub.2 Me    G.sub.3                                  Q201         SMe      SO.sub.2 Ph    Gc                                       Q201         SMe      SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         SMe      SO.sub.2 NHMe  G.sub.3                                  Q201         SMe      SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         SO.sub.2 Me                                                                            COOMe          Gc                                       Q205         SO.sub.2 Me                                                                            COOMe          Gc                                       Q209         SO.sub.2 Me                                                                            COOMe          G.sub.3                                  Q229         SO.sub.2 Me                                                                            COOMe          G.sub.3                                  Q246         SO.sub.2 Me                                                                            COOMe          G.sub.1                                  Q201         SO.sub.2 Me                                                                            COOEt          Gc                                       Q205         SO.sub.2 Me                                                                            COOEt          Gc                                       Q209         SO.sub.2 Me                                                                            COOEt          G.sub.3                                  Q222         SO.sub.2 Me                                                                            COOEt          Gc                                       Q225         SO.sub.2 Me                                                                            COOEt          Gc                                       Q201         SO.sub.2 Me                                                                            COOPri         G.sub.3                                  Q205         SO.sub.2 Me                                                                            COOPri         Gc                                       Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CHCH.sub.2                                                                       G.sub.3                                  Q201         SO.sub.2 Me                                                                            COOCH.sub.2 CCH                                                                              Gc                                       Q201         SO.sub.2 Me                                                                            CONHMe         Gc                                       Q201         SO.sub.2 Me                                                                            CONMe.sub.2    G.sub.2                                  Q201         SO.sub.2 Me                                                                            COMe           Gc                                       Q205         SO.sub.2 Me                                                                            COMe           Gc                                       Q229         SO.sub.2 Me                                                                            COMe           G.sub.3                                  Q201         SO.sub.2 Me                                                                            COEt           Gc                                       Q205         SO.sub.2 Me                                                                            COEt           Gc                                       Q201         SO.sub.2 Me                                                                            COPri          G.sub.3                                  Q201         SO.sub.2 Me                                                                            COPh           Gc                                       Q201         SO.sub.2 Me                                                                            CN             Gc                                       Q205         SO.sub.2 Me                                                                            CN             Gc                                       Q222         SO.sub.2 Me                                                                            CN             Gc                                       Q229         SO.sub.2 Me                                                                            CN             Gc                                       Q201         SO.sub.2 Me                                                                            H              G.sub.2                                  Q201         SO.sub.2 Me                                                                            Me             Gc                                       Q205         SO.sub.2 Me                                                                            Me             Gc                                       Q201         SO.sub.2 Me                                                                            Et             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Pri            Gc                                       Q201         SO.sub.2 Me                                                                            CHCH.sub.2     Gc                                       Q201         SO.sub.2 Me                                                                            CHCHMe         G.sub.1                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         Gc                                       Q205         SO.sub.2 Me                                                                            CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 Ph    G.sub.3                                  Q201         SO.sub.2 Me                                                                            Ph             Gc                                       Q205         SO.sub.2 Me                                                                            Ph             Gc                                       Q209         SO.sub.2 Me                                                                            Ph             Gc                                       Q229         SO.sub.2 Me                                                                            Ph             G.sub.3                                  Q246         SO.sub.2 Me                                                                            Ph             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Ph2-Cl         Gc                                       Q205         SO.sub.2 Me                                                                            Ph2-Me         Gc                                       Q201         SO.sub.2 Me                                                                            Cl             Gc                                       Q205         SO.sub.2 Me                                                                            Cl             Gc                                       Q229         SO.sub.2 Me                                                                            Cl             G.sub.3                                  Q201         SO.sub.2 Me                                                                            Br             G.sub.3                                  Q205         SO.sub.2 Me                                                                            Br             Gc                                       Q201         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q205         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q209         SO.sub.2 Me                                                                            NO.sub.2       Gc                                       Q229         SO.sub.2 Me                                                                            NO.sub.2       G.sub.3                                  Q201         SO.sub.2 Me                                                                            NH.sub.2       Gc                                       Q205         SO.sub.2 Me                                                                            NH.sub.2       G.sub.3                                  Q201         SO.sub.2 Me                                                                            NHMe           Gc                                       Q201         SO.sub.2 Me                                                                            NMe.sub.2      Gc                                       Q205         SO.sub.2 Me                                                                            NMe.sub.2      G.sub.1                                  Q201         SO.sub.2 Me                                                                            NHCOMe         Gc                                       Q205         SO.sub.2 Me                                                                            NHCOMe         Gc                                       Q201         SO.sub.2 Me                                                                            NHCOEt         G.sub.3                                  Q201         SO.sub.2 Me                                                                            NHSO.sub.2 Me  Gc                                       Q201         SO.sub.2 Me                                                                            OMe            G.sub.1                                  Q201         SO.sub.2 Me                                                                            CH.sub.2 OMe   Gc                                       Q205         SO.sub.2 Me                                                                            CH.sub.2 OMe   Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 Me    Gc                                       Q205         SO.sub.2 Me                                                                            SO.sub.2 Me    Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 Ph    G.sub.3                                  Q201         SO.sub.2 Me                                                                            SO.sub.2 OMe   Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         SO.sub.2 Me                                                                            SO.sub.2 NHMe  G.sub.3                                  Q201         SO.sub.2 Me                                                                            SO.sub.2 NMe.sub.2                                                                           Gc                                       Q201         Ph       COOMe          Gc                                       Q205         Ph       COOMe          G.sub.3                                  Q209         Ph       COOMe          Gc                                       Q201         Ph       COOEt          Gc                                       Q205         Ph       COOEt          Gc                                       Q209         Ph       COOEt          G.sub.3                                  Q229         Ph       COOEt          Gc                                       Q201         Ph       COOPri         G.sub.3                                  Q201         Ph       COOCH.sub.2 CH.sub.2 Cl                                                                      Gc                                       Q201         Ph       COOCH.sub.2 CHCH.sub.2                                                                       Gc                                       Q201         Ph       COOCH.sub.2 CCH                                                                              G.sub.3                                  Q201         Ph       CONMe.sub.2    Gc                                       Q201         Ph       COMe           Gc                                       Q205         Ph       COMe           Gc                                       Q201         Ph       COEt           G.sub.3                                  Q201         Ph       CN             Gc                                       Q205         Ph       CN             Gc                                       Q201         Ph       H              G.sub.3                                  Q201         Ph       Me             Gc                                       Q201         Ph       Et             Gc                                       Q201         Ph       CH.sub.2 CH.sub.2 Cl                                                                         G.sub.3                                  Q201         Ph       Ph             Gc                                       Q205         Ph       Ph             Gc                                       Q209         Ph       Ph             G.sub.3                                  Q201         Ph       Cl             Gc                                       Q201         Ph       Br             G.sub.3                                  Q201         Ph       NO.sub.2       Gc                                       Q201         Ph       NH.sub.2       Gc                                       Q201         Ph       NHMe           G.sub.3                                  Q201         Ph       NMe.sub.2      Gc                                       Q201         Ph       NHCOMe         Gc                                       Q201         Ph       NHSO.sub.2 Me  G.sub.1                                  Q201         Ph       CH.sub.2 OMe   Gc                                       Q201         Ph       SO.sub.2 Me    G.sub.3                                  Q201         Ph       SO.sub.2 NH.sub.2                                                                            Gc                                       Q201         Ph       SO.sub.2 NHMe  Gc                                       Q201         Ph       SO.sub.2 NMe.sub.2                                                                           G.sub.3                                  ______________________________________                                    

                  TABLE 4                                                         ______________________________________                                         ##STR26##                                                                    A         B      D      E          W     Gn                                   ______________________________________                                        Q5        H      H      Me         O     Gc                                   CH.sub.2Q5                                                                              H      H      Me         O     Gc                                   Q5        H      H      Et         O     G3                                   Q5        H      H      Prn        O     G3                                   Q5        H      H      CH.sub.2 CHCH.sub.2                                                                      O     G3                                   Q5        H      H      OMe        O     G3                                   Q61       H      H      Me         O     Gc                                   CH.sub.2Q61                                                                             H      H      Me         O     Gc                                   Q61       H      H      Et         O     G3                                   Q61       H      H      Prn        O     G3                                   Q61       H      H      CH.sub.2 CHCH.sub.2                                                                      O     G3                                   Q61       H      H      OMe        O     G3                                   Q26       H      H      Me         O     G3                                   Q26       H      H      Et         O     G3                                   Q26       H      H      OMe        O     G3                                   Q5        H      H      H          S     Gc                                   CH.sub.2Q5                                                                              H      H      H          S     G3                                   Q26       H      H      H          S     Gc                                   Q61       H      H      H          S     Gc                                   CH.sub.2Q61                                                                             H      H      H          S     G3                                   Q5        H      H      H          NH    Gc                                   CH.sub.2Q5                                                                              H      H      H          NH    G3                                   Q26       H      H      H          NH    Gc                                   Q61       H      H      H          NH    Gc                                   CH.sub.2Q61                                                                             H      H      H          NH    G3                                   Q5        H      H      H          NOMe  Gc                                   CH.sub.2Q5                                                                              H      H      H          NOMe  G3                                   Q26       H      H      H          NOMe  Gc                                   Q61       H      H      H          NOMe  Gc                                   CH.sub.2Q61                                                                             H      H      H          NOMe  G3                                   Q201      H      H      Me         O     Gc                                   CH.sub.2Q201                                                                            H      H      Me         O     G.sub.3                              Q201      H      H      Et         O     Gc                                   Q201      H      H      Prn        O     G.sub.3                              Q201      H      H      CH.sub.2 CHCH.sub.2                                                                      O     Gc                                   Q201      H      H      OMe        O     Gc                                   Q205      H      H      Me         O     G.sub.3                              Q205      H      H      Et         O     G.sub.3                              Q205      H      H      OMe        O     G.sub.3                              Q201      H      H      H          S     Gb                                   CH.sub.2Q201                                                                            H      H      H          S     G.sub.3                              Q205      H      H      H          S     Gc                                   Q222      H      H      H          S     G.sub.2                              Q229      H      H      H          S     G.sub.3                              Q201      H      H      H          NH    Gb                                   CH.sub.2Q201                                                                            H      H      H          NH    G.sub.3                              Q205      H      H      H          NH    Gc                                   Q222      H      H      H          NH    G.sub.3                              Q229      H      H      H          NH    G.sub.3                              Q201      H      H      H          NOMe  Gb                                   CH.sub.2Q201                                                                            H      H      H          NOMe  G.sub.3                              Q205      H      H      H          NOMe  Gc                                   Q222      H      H      H          NOMe  Gc                                   Q229      H      H      H          NOMe  G.sub.3                              ______________________________________                                    

                  TABLE 5                                                         ______________________________________                                         ##STR27##                                                                    A           B      D       W2    R22    Gn                                    ______________________________________                                        Q5          H      H       O     Me     Gc                                    CH.sub.2Q5  H      H       O     Me     G3                                    Q5          H      H       O     Et     Gc                                    Q5          H      H       O     Prn    G3                                    Q26         H      H       O     Me     Gc                                    Q26         H      H       O     Et     G3                                    Q61         H      H       O     Me     Gc                                    CH.sub.2Q61 H      H       O     Me     Gc                                    Q61         H      H       O     Et     Gc                                    Q61         H      H       O     Prn    G3                                    Q158        H      H       O     Et     G3                                    Q158        H      H       O     Me     G3                                    Q5          H      H       S     Me     Gc                                    CH.sub.2Q5  H      H       S     Me     G3                                    Q5          H      H       S     Et     Gc                                    Q5          H      H       S     Prn    G3                                    Q26         H      H       S     Me     Gc                                    Q26         H      H       S     Et     G3                                    Q61         H      H       S     Me     Gc                                    CH.sub.2Q61 H      H       S     Me     Gc                                    Q61         H      H       S     Et     Gc                                    Q61         H      H       S     Prn    G3                                    Q158        H      H       S     Et     G3                                    Q158        H      H       S     Me     G3                                    Q201        H      H       O     Me     Gc                                    CH.sub.2Q201                                                                              H      H       O     Me     G.sub.3                               Q201        H      H       O     Et     Gc                                    Q201        H      H       O     Prn    Gc                                    Q205        H      H       O     Me     G.sub.3                               Q205        H      H       O     Et     Gc                                    Q222        H      H       O     Me     Gc                                    Q222        H      H       O     Et     G.sub.3                               Q229        H      H       O     Me     Gc                                    Q229        H      H       O     Et     G.sub.3                               Q201        H      H       S     Me     Gc                                    CH.sub.2Q201                                                                              H      H       S     Me     G.sub.3                               Q201        H      H       S     Et     Gc                                    Q201        H      H       S     Prn    Gc                                    Q205        H      H       S     Me     Gc                                    Q205        H      H       S     Et     Gc                                    Q222        H      H       S     Me     G.sub.3                               Q222        H      H       S     Et     Gc                                    Q229        H      H       S     Me     Gc                                    Q229        H      H       S     Et     G.sub.3                               ______________________________________                                    

                  TABLE 6                                                         ______________________________________                                         ##STR28##                                                                    A            B      D      Az         Gn                                      ______________________________________                                        Q5           H      H      Imidazol-1-yl                                                                            Gc                                      Q5           H      H      Pyrazol-1-yl                                                                             Gc                                      CH.sub.2Q5   H      H      Imidazol-1-yl                                                                            G3                                      CH.sub.2Q5   H      H      Pyrazol-1-yl                                                                             G3                                      Q26          H      H      Imidazol-1-yl                                                                            Gc                                      Q26          H      H      Pyrazol-1-yl                                                                             Gc                                      Q61          H      H      Imidazol-1-yl                                                                            Gc                                      Q61          H      H      Pyrazol-1-yl                                                                             Gc                                      CH.sub.2Q61  H      H      Imidazol-1-yl                                                                            G3                                      CH.sub.2Q61  H      H      Pyrazol-1-yl                                                                             G3                                      Q158         H      H      Imidazol-1-yl                                                                            G3                                      Q158         H      H      Pyrazol-1-yl                                                                             G3                                      Q201         H      H      Imidazol-1-yl                                                                            Gc                                      Q201         H      H      Pyrazol-1-yl                                                                             Gc                                      CH.sub.2Q201 H      H      Imidazol-1-yl                                                                            G.sub.3                                 CH.sub.2Q201 H      H      Pyrazol-1-yl                                                                             G.sub.3                                 Q205         H      H      Imidazol-1-yl                                                                            Gc                                      Q205         H      H      Pyrazol-1-yl                                                                             Gc                                      Q222         H      H      Imidazol-1-yl                                                                            G.sub.3                                 Q222         H      H      Pyrazol-1-yl                                                                             G.sub.3                                 Q229         H      H      Imidazol-1-yl                                                                            Gc                                      Q229         H      H      Pyrazol-1-yl                                                                             Gc                                      ______________________________________                                    

                  TABLE 7                                                         ______________________________________                                         ##STR29##                                                                    A         B       D       J      R23    Gn                                    ______________________________________                                        Q5        H       H       Me     H      Gc                                    Q5        H       H       Me     Me     G3                                    Q5        H       H       Me     OMe    Gc                                    Q5        H       H       Et     H      G3                                    Q5        H       H       Et     Me     G3                                    Q5        H       H       Et     OMe    Gc                                    Q5        H       H       J1     H      G3                                    Q5        H       H       J1     Me     G1                                    Q5        H       H       J1     OMe    G3                                    Q201      H       H       Me     H      Gc                                    Q201      H       H       Me     Me     G.sub.3                               Q201      H       H       Me     OMe    Gc                                    Q201      H       H       Et     H      G.sub.3                               Q201      H       H       Et     Me     G.sub.3                               Q201      H       H       Et     OMe    Gc                                    Q201      H       H       J10    H      G.sub.3                               Q201      H       H       J10    Me     G.sub.1                               Q201      H       H       J10    OMe    G.sub.3                               ______________________________________                                    

                  TABLE 8                                                         ______________________________________                                         ##STR30##                                                                    A        B      D        E         W     Gn                                   ______________________________________                                        Q5       H      COOMe    Me        O     Gc                                   CH.sub.2Q5                                                                             H      COOMe    Me        O     G3                                   Q5       H      COOMe    Et        O     Gc                                   Q5       H      COOMe    Prn       O     Gc                                   Q5       H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q5       H      COOMe    OMe       O     Gc                                   Q26      H      COOMe    Me        O     G3                                   Q26      H      COOMe    Et        O     Gc                                   Q26      H      COOMe    OMe       O     Gc                                   Q61      H      COOMe    Me        O     Gc                                   CH.sub.2Q61                                                                            H      COOMe    Me        O     G3                                   Q61      H      COOMe    Et        O     Gc                                   Q61      H      COOMe    Prn       O     Gc                                   Q61      H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q61      H      COOMe    OMe       O     Gc                                   Q5       H      COOMe    H         S     Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         S     G3                                   Q26      H      COOMe    H         S     Gc                                   Q61      H      COOMe    H         S     Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         S     G3                                   Q5       H      COOMe    H         NH    Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         NH    G3                                   Q26      H      COOMe    H         NH    Gc                                   Q61      H      COOMe    H         NH    Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         NH    G3                                   Q5       H      COOMe    H         NOMe  Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         NOMe  G3                                   Q26      H      COOMe    H         NOMe  Gc                                   Q61      H      COOMe    H         NOMe  Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         NOMe  G3                                   Q5       H      COOEt    Me        O     Gc                                   CH.sub.2Q5                                                                             H      COOEt    Me        O     G3                                   Q5       H      COOEt    Et        O     Gc                                   Q5       H      COOEt    Prn       O     Gc                                   Q5       H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q5       H      COOEt    OMe       O     Gc                                   Q26      H      COOEt    Me        O     G3                                   Q26      H      COOEt    Et        O     Gc                                   Q26      H      COOEt    OMe       O     Gc                                   Q61      H      COOEt    Me        O     Gc                                   CH.sub.2Q61                                                                            H      COOEt    Me        O     G3                                   Q61      H      COOEt    Et        O     Gc                                   Q61      H      COOEt    Prn       O     Gc                                   Q61      H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q61      H      COOEt    OMe       O     Gc                                   Q5       H      COOEt    H         S     Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         S     G3                                   Q26      H      COOEt    H         S     Gc                                   Q61      H      COOEt    H         S     Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         S     G3                                   Q5       H      COOEt    H         NH    Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         NH    G3                                   Q26      H      COOEt    H         NH    Gc                                   Q61      H      COOEt    H         NH    Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         NH    G3                                   Q5       H      COOEt    H         NOMe  Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         NOMe  G3                                   Q26      H      COOEt    H         NOMe  Gc                                   Q61      H      COOEt    H         NOMe  Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         NOMe  G3                                   Q201     H      COOMe    Me        O     Gc                                   CH.sub.2Q201                                                                           H      COOMe    Me        O     G.sub.3                              Q201     H      COOMe    Et        O     Gc                                   Q201     H      COOMe    Prn       O     Gc                                   Q201     H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G.sub.3                              Q201     H      COOMe    OMe       O     Gc                                   Q205     H      COOMe    Me        O     G.sub.3                              Q205     H      COOMe    Et        O     Gc                                   Q205     H      COOMe    OMe       O     Gc                                   Q201     H      COOMe    H         S     Gb                                   CH.sub.2Q201                                                                           H      COOMe    H         S     G.sub.3                              Q205     H      COOMe    H         S     Gc                                   Q222     H      COOMe    H         S     G.sub.3                              Q229     H      COOMe    H         S     G.sub.1                              Q201     H      COOMe    H         NH    Gb                                   CH.sub.2Q201                                                                           H      COOMe    H         NH    G.sub.3                              Q205     H      COOMe    H         NH    Gc                                   Q222     H      COOMe    H         NH    Gc                                   Q229     H      COOMe    H         NH    G.sub.3                              Q201     H      COOMe    H         NOMe  Gb                                   CH.sub.2Q201                                                                           H      COOMe    H         NOMe  G.sub.3                              Q205     H      COOMe    H         NOMe  Gc                                   Q222     H      COOMe    H         NOMe  Gc                                   Q229     H      COOMe    H         NOMe  G.sub.3                              Q201     H      COOEt    Me        O     Gc                                   CH.sub.2Q201                                                                           H      COOEt    Me        O     G.sub.3                              Q201     H      COOEt    Et        O     Gc                                   Q201     H      COOEt    Prn       O     Gc                                   Q201     H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     Gc                                   Q201     H      COOEt    OMe       O     Gc                                   Q205     H      COOEt    Me        O     G.sub.3                              Q205     H      COOEt    Et        O     G.sub.3                              Q205     H      COOEt    OMe       O     Gc                                   Q201     H      COOEt    H         S     Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         S     G.sub.3                              Q205     H      COOEt    H         S     Gc                                   Q222     H      COOEt    H         S     Gc                                   Q229     H      COOEt    H         S     Gc                                   Q201     H      COOEt    H         NH    Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         NH    G.sub.3                              Q205     H      COOEt    H         NH    Gc                                   Q222     H      COOEt    H         NH    Gc                                   Q229     H      COOEt    H         NH    Gc                                   Q201     H      COOEt    H         NOMe  Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         NOMe  G.sub.3                              Q205     H      COOEt    H         NOMe  Gc                                   Q222     H      COOEt    H         NOMe  Gc                                   Q229     H      COOEt    H         NOMe  G.sub. 3                             ______________________________________                                    

                  TABLE 9                                                         ______________________________________                                         ##STR31##                                                                    A         B       D         W2    R22    Gn                                   ______________________________________                                        Q5        H       COOMe     O     Me     Gc                                   CH.sub.2Q5                                                                              H       COOMe     O     Me     G3                                   Q5        H       COOMe     O     Et     Gc                                   Q5        H       COOMe     O     Prn    G3                                   Q26       H       COOMe     O     Me     Gc                                   Q26       H       COOMe     O     Et     G3                                   Q61       H       COOMe     O     Me     Gc                                   CH.sub.2Q61                                                                             H       COOMe     O     Me     G3                                   Q61       H       COOMe     O     Et     Gc                                   Q61       H       COOMe     O     Prn    G3                                   Q158      H       COOMe     O     Me     Gc                                   Q158      H       COOMe     O     Et     G3                                   Q5        H       COOMe     S     Me     Gc                                   CH.sub.2Q5                                                                              H       COOMe     S     Me     G3                                   Q5        H       COOMe     S     Et     Gc                                   Q5        H       COOMe     S     Prn    G3                                   Q26       H       COOMe     S     Me     Gc                                   Q26       H       COOMe     S     Et     G3                                   Q61       H       COOMe     S     Me     Gc                                   CH.sub.2Q61                                                                             H       COOMe     S     Me     G3                                   Q61       H       COOMe     S     Et     Gc                                   Q61       H       COOMe     S     Prn    G3                                   Q158      H       COOMe     S     Me     Gc                                   Q158      H       COOMe     S     Et     G3                                   Q5        H       COOEt     O     Me     Gc                                   CH.sub.2Q5                                                                              H       COOEt     O     Me     G3                                   Q5        H       COOEt     O     Et     Gc                                   Q5        H       COOEt     O     Prn    G3                                   Q26       H       COOEt     O     Me     Gc                                   Q26       H       COOEt     O     Et     G3                                   Q61       H       COOEt     O     Me     Gc                                   CH.sub.2Q61                                                                             H       COOEt     O     Me     G3                                   Q61       H       COOEt     O     Et     Gc                                   Q61       H       COOEt     O     Prn    G3                                   Q158      H       COOEt     O     Me     Gc                                   Q158      H       COOEt     O     Et     G3                                   Q5        H       COOEt     S     Me     Gc                                   CH.sub.2Q5                                                                              H       COOEt     S     Me     G3                                   Q5        H       COOEt     S     Et     Gc                                   Q5        H       COOEt     S     Prn    G3                                   Q26       H       COOEt     S     Me     Gc                                   Q26       H       COOEt     S     Et     G3                                   Q61       H       COOEt     S     Me     Gc                                   CH.sub.2Q61                                                                             H       COOEt     S     Me     G3                                   Q61       H       COOEt     S     Et     Gc                                   Q61       H       COOEt     S     Prn    G3                                   Q158      H       COOEt     S     Me     Gc                                   Q158      H       COOEt     S     Et     G3                                   Q201      H       COOMe     O     Me     Gc                                   CH.sub.2Q201                                                                            H       COOMe     O     Me     G3                                   Q201      H       COOMe     O     Et     Gc                                   Q201      H       COOMe     O     Prn    Gc                                   Q205      H       COOMe     O     Me     Gc                                   Q205      H       COOMe     O     Et     Gc                                   Q222      H       COOMe     O     Me     Gc                                   Q222      H       COOMe     O     Et     G3                                   Q229      H       COOMe     O     Me     G3                                   Q229      H       COOMe     O     Et     Gc                                   Q201      H       COOMe     S     Me     Gc                                   CH.sub.2Q201                                                                            H       COOMe     S     Me     G3                                   Q201      H       COOMe     S     Et     Gc                                   Q201      H       COOMe     S     Prn    Gc                                   Q205      H       COOMe     S     Me     Gc                                   Q205      H       COOMe     S     Et     Gc                                   Q222      H       COOMe     S     Me     Gc                                   Q222      H       COOMe     S     Et     G3                                   Q229      H       COOMe     S     Me     Gc                                   Q229      H       COOMe     S     Et     G3                                   Q201      H       COOEt     O     Me     Gc                                   CH.sub.2Q201                                                                            H       COOEt     O     Me     G3                                   Q201      H       COOEt     O     Et     Gc                                   Q201      H       COOEt     O     Prn    Gc                                   Q205      H       COOEt     O     Me     Gc                                   Q205      H       COOEt     O     Et     Gc                                   Q222      H       COOEt     O     Me     Gc                                   Q222      H       COOEt     O     Et     G3                                   Q229      H       COOEt     O     Me     Gc                                   Q229      H       COOEt     O     Et     G3                                   Q201      H       COOEt     S     Me     Gc                                   CH.sub.2Q201                                                                            H       COOEt     S     Me     G3                                   Q201      H       COOEt     S     Et     Gc                                   Q201      H       COOEt     S     Prn    Gc                                   Q205      H       COOEt     S     Me     Gc                                   Q205      H       COOEt     S     Et     G3                                   Q222      H       COOEt     S     Me     Gc                                   Q222      H       COOEt     S     Et     Gc                                   Q229      H       COOEt     S     Me     G1                                   Q229      H       COOEt     S     Et     G1                                   ______________________________________                                    

                  TABLE 10                                                        ______________________________________                                         ##STR32##                                                                    A           B      D         Az        Gn                                     ______________________________________                                        Q5          H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q5          H      COOMe     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q5  H      COOMe     Imidazol-1-yl                                                                           G1                                     CH.sub.2Q5  H      COOMe     Pyrazol-1-yl                                                                            G1                                     Q26         H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q26         H      COOMe     Pyrazol-1-yl                                                                            Gc                                     Q61         H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q61         H      COOMe     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q61 H      COOMe     Imidazol-1-yl                                                                           G3                                     CH.sub.2Q61 H      COOMe     Pyrazol-1-yl                                                                            G3                                     Q5          H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q5          H      COOEt     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q5  H      COOEt     Imidazol-1-yl                                                                           G3                                     CH.sub.2Q5  H      COOEt     Pyrazol-1-yl                                                                            G3                                     Q26         H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q26         H      COOEt     Pyrazol-1-yl                                                                            Gc                                     Q61         H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q61         H      COOEt     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q61 H      COOEt     Imidazol-1-yl                                                                           G3                                     CH.sub.2Q61 H      COOEt     Pyrazol-1-yl                                                                            G3                                     Q201        H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q201        H      COOMe     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q201                                                                              H      COOMe     Imidazol-1-yl                                                                           G1                                     CH.sub.2Q201                                                                              H      COOMe     Pyrazol-1-yl                                                                            G1                                     Q205        H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q205        H      COOMe     Pyrazol-1-yl                                                                            Gc                                     Q222        H      COOMe     Imidazol-1-yl                                                                           Gc                                     Q222        H      COOMe     Pyrazol-1-yl                                                                            Gc                                     Q229        H      COOMe     Imidazol-1-yl                                                                           G3                                     Q229        H      COOMe     Pyrazol-1-yl                                                                            G3                                     Q201        H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q201        H      COOEt     Pyrazol-1-yl                                                                            Gc                                     CH.sub.2Q201                                                                              H      COOEt     Imidazol-1-yl                                                                           G3                                     CH.sub.2Q201                                                                              H      COOEt     Pyrazol-1-yl                                                                            G3                                     Q205        H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q205        H      COOEt     Pyrazol-1-yl                                                                            Gc                                     Q222        H      COOEt     Imidazol-1-yl                                                                           Gc                                     Q222        H      COOEt     Pyrazol-1-yl                                                                            Gc                                     Q229        H      COOEt     Imidazol-1-yl                                                                           G3                                     Q229        H      COOEt     Pyrazol-1-yl                                                                            G3                                     ______________________________________                                    

                  TABLE 11                                                        ______________________________________                                         ##STR33##                                                                    A           B      D         J     R23   Gn                                   ______________________________________                                        Q5          H      COOMe     Me    H     G3                                   Q5          H      COOMe     Me    Me    Gc                                   Q5          H      COOMe     Me    OMe   Gc                                   Q5          H      COOMe     Et    H     Gc                                   Q5          H      COOMe     Et    Me    Gc                                   Q5          H      COOMe     Et    OMe   G3                                   Q5          H      COOMe     J2    H     Gc                                   Q5          H      COOMe     J2    Me    Gc                                   Q5          H      COOMe     J2    OMe   G3                                   Q5          H      COOEt     Me    H     Gc                                   Q5          H      COOEt     Me    Me    G3                                   Q5          H      COOEt     Me    OMe   Gc                                   Q5          H      COOEt     Et    H     Gc                                   Q5          H      COOEt     Et    Me    G3                                   Q5          H      COOEt     Et    OMe   Gc                                   Q5          H      COOEt     J3    H     Gc                                   Q5          H      COOEt     J3    Me    Gc                                   Q5          H      COOEt     J3    OMe   Gc                                   CH.sub.2Q5  H      COOMe     Me    H     G3                                   CH.sub.2Q5  H      COOEt     Me    OMe   Gc                                   Q26         H      COOMe     Me    H     Gc                                   Q26         H      COOEt     Me    OMe   Gc                                   Q61         H      COOMe     Me    H     G3                                   Q61         H      COOMe     Me    Me    Gc                                   Q61         H      COOMe     Me    OMe   Gc                                   Q61         H      COOMe     Et    H     Gc                                   Q61         H      COOMe     Et    Me    Gc                                   Q61         H      COOMe     Et    OMe   G3                                   Q61         H      COOMe     J4    H     Gc                                   Q61         H      COOMe     J4    Me    Gc                                   Q61         H      COOMe     J4    OMe   G3                                   Q61         H      COOEt     Me    H     Gc                                   Q61         H      COOEt     Me    Me    G3                                   Q61         H      COOEt     Me    OMe   Gc                                   Q61         H      COOEt     Et    H     Gc                                   Q61         H      COOEt     Et    Me    G3                                   Q61         H      COOEt     Et    OMe   Gc                                   Q61         H      COOEt     J5    H     Gc                                   Q61         H      COOEt     J5    Me    Gc                                   Q61         H      COOEt     J5    OMe   Gc                                   CH.sub.2Q61 H      COOMe     Me    H     G3                                   CH.sub.2Q61 H      COOEt     Me    OMe   Gc                                   Q201        H      COOMe     Me    H     G3                                   Q201        H      COOMe     Me    Me    Gc                                   Q201        H      COOMe     Me    OMe   Gc                                   Q201        H      COOMe     Et    H     Gc                                   Q201        H      COOMe     Et    Me    Gc                                   Q201        H      COOMe     Et    OMe   G3                                   Q201        H      COOMe     J11   H     Gc                                   Q201        H      COOMe     J11   Me    Gc                                   Q201        H      COOMe     J11   OMe   G3                                   Q201        H      COOEt     Me    H     Gc                                   Q201        H      COOEt     Me    Me    G3                                   Q201        H      COOEt     Me    OMe   Gc                                   Q201        H      COOEt     Et    H     Gc                                   Q201        H      COOEt     Et    Me    G3                                   Q201        H      COOEt     Et    OMe   Gc                                   Q201        H      COOEt     J12   H     Gc                                   Q201        H      COOEt     J12   Me    Gc                                   Q201        H      COOEt     J12   OMe   Gc                                   CH.sub.2Q201                                                                              H      COOMe     Me    H     G3                                   CH.sub.2Q201                                                                              H      COOEt     Me    OMe   Gc                                   Q205        H      COOMe     Me    H     Gc                                   Q205        H      COOEt     Me    OMe   Gc                                   Q229        H      COOMe     Me    H     Gc                                   Q229        H      COOEt     Me    OMe   G3                                   ______________________________________                                    

                  TABLE 12                                                        ______________________________________                                         ##STR34##                                                                    A        B      D        E         W     Gn                                   ______________________________________                                        Q5       H      COOMe    Me        O     Gc                                   CH.sub.2Q5                                                                             H      COOMe    Me        O     G3                                   Q5       H      COOMe    Et        O     Gc                                   Q5       H      COOMe    Prn       O     Gc                                   Q5       H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q5       H      COOMe    OMe       O     Gc                                   Q26      H      COOMe    Me        O     G3                                   Q26      H      COOMe    Et        O     Gc                                   Q26      H      COOMe    OMe       O     Gc                                   Q61      H      COOMe    Me        O     Gc                                   CH.sub.2Q61                                                                            H      COOMe    Me        O     G3                                   Q61      H      COOMe    Et        O     Gc                                   Q61      H      COOMe    Prn       O     Gc                                   Q61      H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q61      H      COOMe    OMe       O     Gc                                   Q5       H      COOMe    H         S     Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         S     G3                                   Q26      H      COOMe    H         S     Gc                                   Q61      H      COOMe    H         S     Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         S     G3                                   Q5       H      COOMe    H         NH    Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         NH    G3                                   Q26      H      COOMe    H         NH    Gc                                   Q61      H      COOMe    H         NH    Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         NH    G3                                   Q5       H      COOMe    H         NOMe  Gb                                   CH.sub.2Q5                                                                             H      COOMe    H         NOMe  G3                                   Q26      H      COOMe    H         NOMe  Gc                                   Q61      H      COOMe    H         NOMe  Gc                                   CH.sub.2Q61                                                                            H      COOMe    H         NOMe  G3                                   Q5       H      COOEt    Me        O     Gc                                   CH.sub.2Q5                                                                             H      COOEt    Me        O     G3                                   Q5       H      COOEt    Et        O     Gc                                   Q5       H      COOEt    Prn       O     Gc                                   Q5       H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q5       H      COOEt    OMe       O     Gc                                   Q26      H      COOEt    Me        O     G3                                   Q26      H      COOEt    Et        O     Gc                                   Q26      H      COOEt    OMe       O     Gc                                   Q61      H      COOEt    Me        O     Gc                                   CH.sub.2Q61                                                                            H      COOEt    Me        O     G3                                   Q61      H      COOEt    Et        O     Gc                                   Q61      H      COOEt    Prn       O     Gc                                   Q61      H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q61      H      COOEt    OMe       O     Gc                                   Q5       H      COOEt    H         S     Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         S     G3                                   Q26      H      COOEt    H         S     Gc                                   Q61      H      COOEt    H         S     Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         S     G3                                   Q5       H      COOEt    H         NH    Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         NH    G3                                   Q26      H      COOEt    H         NH    Gc                                   Q61      H      COOEt    H         NH    Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         NH    G3                                   Q5       H      COOEt    H         NOMe  Gb                                   CH.sub.2Q5                                                                             H      COOEt    H         NOMe  G3                                   Q26      H      COOEt    H         NOMe  Gc                                   Q61      H      COOEt    H         NOMe  Gc                                   CH.sub.2Q61                                                                            H      COOEt    H         NOMe  G3                                   Q201     H      COOMe    Me        O     Gc                                   CH.sub.2Q201                                                                           H      COOMe    Me        O     G3                                   Q201     H      COOMe    Et        O     Gc                                   Q201     H      COOMe    Prn       O     Gc                                   Q201     H      COOMe    CH.sub.2 CHCH.sub.2                                                                     O     G3                                   Q201     H      COOMe    OMe       O     Gc                                   Q205     H      COOMe    Me        O     G3                                   Q205     H      COOMe    Et        O     Gc                                   Q205     H      COOMe    OMe       O     Gc                                   Q201     H      COOMe    H         S     Gb                                   CH.sub.2Q201                                                                           H      COOMe    H         S     G3                                   Q205     H      COOMe    H         S     Gc                                   Q222     H      COOMe    H         S     G3                                   Q229     H      COOMe    H         S     G1                                   Q201     H      COOMe    H         NH    Gb                                   CH.sub.2Q201                                                                           COOMe  H        NH        G3                                         Q205     H      COOMe    H         NH    Gc                                   Q222     H      COOMe    H         NH    Gc                                   Q229     H      COOMe    H         NH    G3                                   Q201     H      COOMe    H         NOMe  Gb                                   CH.sub.2 Q201                                                                          H      COOMe    H         NOMe  G3                                   Q205     H      COOMe    H         NOMe  Gc                                   Q222     H      COOMe    H         NOMe  Gc                                   Q229     H      COOMe    H         NOMe  G3                                   Q201     H      COOEt    Me        O     Gc                                   CH.sub.2Q201                                                                           H      COOEt    Me        O     G3                                   Q201     H      COOEt    Et        O     Gc                                   Q201     H      COOEt    Prn       O     Gc                                   Q201     H      COOEt    CH.sub.2 CHCH.sub.2                                                                     O     Gc                                   Q201     H      COOEt    OMe       O     Gc                                   Q205     H      COOEt    Me        O     G3                                   Q205     H      COOEt    Et        O     G3                                   Q205     H      COOEt    OMe       O     Gc                                   Q201     H      COOEt    H         S     Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         S     G3                                   Q205     H      COOEt    H         S     Gc                                   Q222     H      COOEt    H         S     Gc                                   Q229     H      COOEt    H         S     Gc                                   Q201     H      COOEt    H         NH    Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         NH    G3                                   Q205     H      COOEt    H         NH    Gc                                   Q222     H      COOEt    H         NH    Gc                                   Q229     H      COOEt    H         NH    Gc                                   Q201     H      COOEt    H         NOMe  Gb                                   CH.sub.2Q201                                                                           H      COOEt    H         NOMe  G3                                   Q205     H      COOEt    H         NOMe  Gc                                   Q222     H      COOEt    H         NOMe  Gc                                   Q229     H      COOEt    H         NOMe  G3                                   ______________________________________                                    

                  TABLE 13                                                        ______________________________________                                         ##STR35##                                                                    A         B         D      W2     R22   Gn                                    ______________________________________                                        Q5        H         COOMe  O      Me    Gc                                    CH.sub.2 - Q5                                                                           H         COOMe  O      Me    G3                                    Q5        H         COOMe  O      Et    Gc                                    Q5        H         COOMe  O      Prn   G3                                    Q26       H         COOMe  O      Me    Gc                                    Q26       H         COOMe  O      Et    G3                                    Q61       H         COOMe  O      Me    Gc                                    CH.sub.2 - Q61                                                                          H         COOMe  O      Me    G3                                    Q61       H         COOMe  O      Et    Gc                                    Q61       H         COOMe  O      Prn   G3                                    Q158      H         COOMe  O      Me    Gc                                    Q158      H         COOMe  O      Et    G3                                    Q5        H         COOMe  S      Me    Gc                                    CH.sub.2 - Q5                                                                           H         COOMe  S      Me    G3                                    Q5        H         COOMe  S      Et    Gc                                    Q5        H         COOMe  S      Prn   G3                                    Q26       H         COOMe  S      Me    Gc                                    Q26       H         COOMe  S      Et    G3                                    Q61       H         COOMe  S      Me    Gc                                    CH.sub.2 - Q61                                                                          H         COOMe  S      Me    G3                                    Q61       H         COOMe  S      Et    Gc                                    Q61       H         COOMe  S      Prn   G3                                    Q158      H         COOMe  S      Me    Gc                                    Q158      H         COOMe  S      Et    G3                                    Q5        H         COOEt  O      Me    Gc                                    CH.sub.2 - Q5                                                                           H         COOEt  O      Me    G3                                    Q5        H         COOEt  O      Et    Gc                                    Q5        H         COOEt  O      Prn   G3                                    Q26       H         COOEt  O      Me    Gc                                    Q26       H         COOEt  O      Et    G3                                    Q61       H         COOEt  O      Me    Gc                                    CH.sub.2 - Q61                                                                          H         COOEt  O      Me    G3                                    Q61       H         COOEt  O      Et    Gc                                    Q61       H         COOEt  O      Prn   G3                                    Q158      H         COOEt  O      Me    Gc                                    Q158      H         COOEt  O      Et    G3                                    Q5        H         COOEt  S      Me    Gc                                    CH.sub.2 - Q5                                                                           H         COOEt  S      Me    G3                                    Q5        H         COOEt  S      Et    Gc                                    Q5        H         COOEt  S      Prn   G3                                    Q26       H         COOEt  S      Me    Gc                                    Q26       H         COOEt  S      Et    G3                                    Q61       H         COOEt  S      Me    Gc                                    CH.sub.2 - Q61                                                                          H         COOEt  S      Me    G3                                    Q61       H         COOEt  S      Et    Gc                                    Q61       H         COOEt  S      Prn   G3                                    Q158      H         COOEt  S      Me    Gc                                    Q158      H         COOEt  S      Et    G3                                    Q201      H         COOMe  O      Me    Gc                                    CH.sub.2 - Q201                                                                         H         COOMe  O      Me    G.sub.3                               Q201      H         COOMe  O      Et    Gc                                    Q201      H         COOMe  O      Prn   Gc                                    Q205      H         COOMe  O      Me    Gc                                    Q205      H         COOMe  O      Et    Gc                                    Q222      H         COOMe  O      Me    Gc                                    Q222      H         COOMe  O      Et    G.sub.3                               Q229      H         COOMe  O      Me    G.sub.3                               Q229      H         COOMe  O      Et    Gc                                    Q201      H         COOMe  S      Me    Gc                                    CH.sub.2 - Q201                                                                         H         COOMe  S      Me    G.sub.3                               Q201      H         COOMe  S      Et    Gc                                    Q201      H         COOMe  S      Prn   Gc                                    Q205      H         COOMe  S      Me    Gc                                    Q205      H         COOMe  S      Et    Gc                                    Q222      H         COOMe  S      Me    Gc                                    Q222      H         COOMe  S      Et    G.sub.3                               Q229      H         COOMe  S      Me    Gc                                    Q229      H         COOMe  S      Et    G.sub.3                               Q201      H         COOEt  O      Me    Gc                                    CH.sub.2 - Q201                                                                         H         COOEt  O      Me    G.sub.3                               Q201      H         COOEt  O      Et    Gc                                    Q201      H         COOEt  O      Prn   Gc                                    Q205      H         COOEt  O      Me    Gc                                    Q205      H         COOEt  O      Et    Gc                                    Q222      H         COOEt  O      Me    Gc                                    Q222      H         COOEt  O      Et    G.sub.3                               Q229      H         COOEt  O      Me    Gc                                    Q229      H         COOEt  O      Et    G.sub..sub.3                          Q201      H         COOEt  S      Me    Gc                                    CH.sub.2 - Q201                                                                         H         COOEt  S      Me    G.sub.3                               Q201      H         COOEt  S      Et    Gc                                    Q201      H         COOEt  S      Prn   Gc                                    Q205      H         COOEt  S      Me    Gc                                    Q205      H         COOEt  S      Et    G.sub.3                               Q222      H         COOEt  S      Me    Gc                                    Q222      H         COOEt  S      Et    Gc                                    Q229      H         COOEt  S      Me    G.sub.1                               Q229      H         COOEt  S      Et    G.sub.1                               ______________________________________                                    

                  TABLE 14                                                        ______________________________________                                         ##STR36##                                                                    A         B       D         Az       Gn                                       ______________________________________                                        Q5        H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q5        H       COOMe     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q5                                                                           H       COOMe     Imidazol-1-yl                                                                          G.sub.1                                  CH.sub.2 - Q5                                                                           H       COOMe     Pyrazol-1-yl                                                                           G.sub.1                                  Q26       H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q26       H       COOMe     Pyrazol-1-yl                                                                           Gc                                       Q61       H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q61       H       COOMe     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q61                                                                          H       COOMe     Imidazol-1-yl                                                                          G.sub.3                                  CH.sub.2 - Q61                                                                          H       COOMe     Pyrazol-1-yl                                                                           G.sub.3                                  Q5        H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q5        H       COOEt     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q5                                                                           H       COOEt     Imidazol-1-yl                                                                          G.sub.3                                  CH.sub.2 - Q5                                                                           H       COOEt     Pyrazol-1-yl                                                                           G.sub.3                                  Q26       H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q26       H       COOEt     Pyrazol-1-yl                                                                           Gc                                       Q61       H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q61       H       COOEt     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q61                                                                          H       COOEt     Imidazol-1-yl                                                                          G.sub.3                                  CH.sub.2 - Q61                                                                          H       COOEt     Pyrazol-1-yl                                                                           G.sub.3                                  Q201      H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q201      H       COOMe     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q201                                                                         H       COOMe     Imidazol-1-yl                                                                          G.sub.1                                  CH.sub.2 - Q201                                                                         H       COOMe     Pyrazol-1-yl                                                                           G.sub.1                                  Q205      H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q205      H       COOMe     Pyrazol-1-yl                                                                           Gc                                       Q222      H       COOMe     Imidazol-1-yl                                                                          Gc                                       Q222      H       COOMe     Pyrazol-1-yl                                                                           Gc                                       Q229      H       COOMe     Imidazol-1-yl                                                                          G.sub.3                                  Q229      H       COOMe     Pyrazol-1-yl                                                                           G.sub.3                                  Q201      H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q201      H       COOEt     Pyrazol-1-yl                                                                           Gc                                       CH.sub.2 - Q201                                                                         H       COOEt     Imidazol-1-yl                                                                          G.sub.3                                  CH.sub.2 - Q201                                                                         H       COOEt     Pyrazol-1-yl                                                                           G.sub.3                                  Q205      H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q205      H       COOEt     Pyrazol-1-yl                                                                           Gc                                       Q222      H       COOEt     Imidazol-1-yl                                                                          Gc                                       Q222      H       COOEt     Pyrazol-1-yl                                                                           Gc                                       Q229      H       COOEt     Imidazol-1-yl                                                                          G.sub.3                                  Q229      H       COOEt     Pyrazol-1-yl                                                                           G.sub.3                                  ______________________________________                                    

                  TABLE 15                                                        ______________________________________                                         ##STR37##                                                                    A         B       D        J      R.sup.23                                                                           Gn                                     ______________________________________                                        Q5        H       COOMe    Me     H    G3                                     Q5        H       COOMe    Me     Me   Gc                                     Q5        H       COOMe    Me     OMe  Gc                                     Q5        H       COOMe    Et     H    Gc                                     Q5        H       COOMe    Et     Me   Gc                                     Q5        H       COOMe    Et     OMe  G3                                     Q5        H       COOMe    J6     H    Gc                                     Q5        H       COOMe    J6     Me   Gc                                     Q5        H       COOMe    J6     OMe  G3                                     Q5        H       COOEt    Me     H    Gc                                     Q5        H       COOEt    Me     Me   G3                                     Q5        H       COOEt    Me     OMe  Gc                                     Q5        H       COOEt    Et     H    Gc                                     Q5        H       COOEt    Et     Me   G3                                     Q5        H       COOEt    Et     OMe  Gc                                     Q5        H       COOEt    J7     H    Gc                                     Q5        H       COOEt    J7     Me   Gc                                     Q5        H       COOEt    J7     OMe  Gc                                     CH.sub.2 - Q5                                                                           H       COOMe    Me     H    G3                                     CH.sub.2 - Q5                                                                           H       COOEt    Me     OMe  Gc                                     Q26       H       COOMe    Me     H    Gc                                     Q26       H       COOEt    Me     OMe  Gc                                     Q61       H       COOMe    Me     H    G3                                     Q61       H       COOMe    Me     Me   Gc                                     Q61       H       COOMe    Me     OMe  Gc                                     Q61       H       COOMe    Et     H    Gc                                     Q61       H       COOMe    Et     Me   Gc                                     Q61       H       COOMe    Et     OMe  G3                                     Q61       H       COOMe    J8     H    Gc                                     Q61       H       COOMe    J8     Me   Gc                                     Q61       H       COOMe    J8     OMe  G3                                     Q61       H       COOEt    Me     H    Gc                                     Q61       H       COOEt    Me     Me   G3                                     Q61       H       COOEt    Me     OMe  Gc                                     Q61       H       COOEt    Et     H    Gc                                     Q61       H       COOEt    Et     Me   G3                                     Q61       H       COOEt    Et     OMe  Gc                                     Q61       H       COOEt    J9     H    Gc                                     Q61       H       COOEt    J9     Me   Gc                                     Q61       H       COOEt    J9     OMe  Gc                                     CH.sub.2 - Q61                                                                          H       COOMe    Me     H    G3                                     CH.sub.2 - Q61                                                                          H       COOEt    Me     OMe  Gc                                     Q201      H       COOMe    Me     H    G.sub.3                                Q201      H       COOMe    Me     Me   Gc                                     Q201      H       COOMe    Me     OMe  Gc                                     Q201      H       COOMe    Et     H    Gc                                     Q201      H       COOMe    Et     Me   Gc                                     Q201      H       COOMe    Et     OMe  G.sub.3                                Q201      H       COOMe    J13    H    Gc                                     Q201      H       COOMe    J13    Me   Gc                                     Q201      H       COOMe    J13    OMe  G.sub.3                                Q201      H       COOEt    Me     H    Gc                                     Q201      H       COOEt    Me     Me   G.sub.3                                Q201      H       COOEt    Me     OMe  Gc                                     Q201      H       COOEt    Et     H    Gc                                     Q201      H       COOEt    Et     Me   G.sub.3                                Q201      H       COOEt    Et     OMe  Gc                                     Q201      H       COOEt    J14    H    Gc                                     Q201      H       COOEt    J14    Me   Gc                                     Q201      H       COOEt    J14    OMe  Gc                                     CH.sub.2 - Q201                                                                         H       COOMe    Me     H    G.sub.3                                CH.sub.2 - Q201                                                                         H       COOEt    Me     OMe  Gc                                     Q205      H       COOMe    Me     H    Gc                                     Q205      H       COOEt    Me     OMe  Gc                                     Q229      H       COOMe    Me     H    Gc                                     Q229      H       COOEt    Me     OMe  G.sub.3                                ______________________________________                                    

In application of the compounds of this invention as herbicides, theycan be applied by mixing with suitable carriers such as solid carriers,including for example clay, talc, bentonite, diatomaceous earth andothers, or liquid carriers, including for example water, alcohols(methanol, ethanol and the like), aromatic hydrocarbons (benzene,toluene, xylene and the like), chlorinated hydrocarbons, ethers,ketones, esters (ethyl acetate etc.), acid amides (dimethylformamideetc.) and others. They can be provided for practical use with additionof any desired additive selected from an emulsifier, a dispersing agent,a suspending agent, a penetrating agent, a spreader and a stabilizer andin any desired form such as a soluble concentrate, an emulsifiableconcentrate, a wettable powder, a dust, a granule, a flowable, etc.

In the following, there are shown examples of formulations of herbicidescontaining the compounds of this invention as active ingredients, butthey are not limitative of this invention. In the exemplary formulationsshown below, "parts" means "parts by weight".

    ______________________________________                                        Exemplary Formulation 1: Wettable powder                                      ______________________________________                                        Compound No. 11 of this invention                                                                         20 parts                                          Zeeklite A                  76 parts                                          (kaolin type clay; trade name; produced by Zeeklite                           Kogyo Co., Ltd.)                                                              Solpol 5039                  2 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          Carplex (anticaking agent)   2 parts                                          (white carbon; trade name, produced by Shionogi                               Seiyaku Co., Ltd.)                                                            ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare awettable powder.

    ______________________________________                                        Exemplary Formulation 2: Wettable powder                                      ______________________________________                                        Compound No. 6 of this invention                                                                          40 parts                                          Zeeklite A                  54 parts                                          (kaolin type clay; trade name; produced by Zeeklite                           Kogyo Co., Ltd.)                                                              Solpol 5039                  2 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          Carplex (anticaking agent)   4 parts                                          (white carbon; trade name, produced by Shionogi                               Seiyaku Co., Ltd.)                                                            ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare awettable powder.

    ______________________________________                                        Exemplary Formulation 3: Emulsifiable concentrate                             ______________________________________                                        Compound No. 3 of this invention                                                                           5 parts                                          Xylene                      75 parts                                          Dimethylformamide           15 parts                                          Solpol 2680                  5 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiableconcentrate. In use, the above emulsifiable concentrate is diluted 10 to10,000 times and sprayed in an amount of 0.005 to 10 kg per hectare interms of the active ingredient.

    ______________________________________                                        Exemplary Formulation 4: Flowable                                             ______________________________________                                        Compound No. 11 of this invention                                                                        25     parts                                       Agrisol S-710              10     parts                                       (nonionic surfactant; trade name; produced by Kao                             Co., Ltd.)                                                                    Runox 1000C                0.5    part                                        (anionic surfactant; trade name; produced by Toho                             Kagaku Co., Ltd.)                                                             1% Rhodopol water          20     parts                                       (thickener; trade name, produced by Rhone-Poulenc                             Co., Ltd.)                                                                    Water                      44.5   parts                                       ______________________________________                                    

The above components are mixed homogeneously to provide a flowableagent.

    ______________________________________                                        Exemplary Formulation 5: Flowable                                             ______________________________________                                        Compound No. 9 of this invention                                                                         40     parts                                       Agrisol S-710              10     parts                                       (nonionic surfactant; trade name; produced by Kao                             Co., Ltd.)                                                                    Runox 1000C                0.5    part                                        (anionic surfactant; trade name; produced by Toho                             Kagaku Co., Ltd.)                                                             1% Rhodopol water          20     parts                                       (thickener; trade name, produced by Rhone-Poulenc                             Co., Ltd.)                                                                    Water                      29.5   parts                                       ______________________________________                                    

The above components are mixed homogeneously to provide a flowableagent.

    ______________________________________                                        Exemplary Formulation 6: Granule                                              ______________________________________                                        Compound No. 8 of this invention                                                                    1        part                                           Bentonite             55       parts                                          Talc                  44       parts                                          ______________________________________                                    

The above components are mixed and pulverized homogeneously, then asmall amount of water is added and the whole is stirred, kneaded andgranulated by excluding granulator, then dried to prepare a granule.

    ______________________________________                                        Exemplary Formulation 7: Wettable powder                                      ______________________________________                                        Compound No. 24 of this invention                                                                         20 parts                                          Zeeklite A                  76 parts                                          (kaolin type clay; trade name; produced by Zeeklite                           Kogyo Co., Ltd.)                                                              Solpol 5039                  2 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          Carplex (anticaking agent)   2 parts                                          (white carbon; trade name, produced by Shionogi                               Seiyaku Co., Ltd.)                                                            ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare awettable powder.

    ______________________________________                                        Exemplary Formulation 8: Wettable powder                                      ______________________________________                                        Compound No. 21 of this invention                                                                         40 parts                                          Zeeklite A                  54 parts                                          (kaolin type clay; trade name; produced by Zeeklite                           Kogyo Co., Ltd.)                                                              Solpol 5039                  2 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          Carplex (anticaking agent)   4 parts                                          (white carbon; trade name, produced by Shionogi                               Seiyaku Co., Ltd.)                                                            ______________________________________                                    

The above components are mixed and pulverized homogeneously to prepare awettable powder.

    ______________________________________                                        Exemplary Formulation 9: Emulsifiable concentrate                             ______________________________________                                        Compound No. 22 of this invention                                                                          5 parts                                          Xylene                      75 parts                                          Dimethylformamide           15 parts                                          Solpol 2680                  5 parts                                          (mixture of nonionic surfactant and anionic surfac-                           tant; trade name; produced by Toho Kagaku Co., Ltd.)                          ______________________________________                                    

The above components are homogeneously mixed to prepare an emulsifiableconcentrate. In use, the above emulsifiable concentrate is diluted 10 to10,000 times and sprayed in an amount of 0.005 to 10 kg per hectare interms of the active ingredient.

    ______________________________________                                        Exemplary Formulation 10: Flowable                                            ______________________________________                                        Compound No. 24 of this invention                                                                        25     parts                                       Agrisol S-710              10     parts                                       (nonionic surfactant; trade name; produced by Kao                             Co., Ltd.)                                                                    Runox 1000C                0.5    part                                        (anionic surfactant; trade name; produced by Toho                             Kagaku Co., Ltd.)                                                             1% Rhodopol water          20     parts                                       (thickener; trade name, produced by Rhone-Poulenc                             Co., Ltd.)                                                                    Water                      44.5   parts                                       ______________________________________                                    

The above components are mixed homogeneously to provide a flowableagent.

    ______________________________________                                        Exemplary Formulation 11: Flowable                                            ______________________________________                                        Compound No. 21 of this invention                                                                        40     parts                                       Agrisol S-710              10     parts                                       (nonionic surfactant; trade name; produced by Kao                             Co., Ltd.)                                                                    Runox 1000C                0.5    part                                        (anionic surfactant; trade name; produced by Toho                             Kagaku Co., Ltd.)                                                             1% Rhodopol water          20     parts                                       (thickener; trade name, produced by Rhone-Poulenc                             Co., Ltd.)                                                                    Water                      29.5   parts                                       ______________________________________                                    

The above components are mixed homogeneously to provide a flowableagent.

    ______________________________________                                        Exemplary Formulation 12: Granule                                             ______________________________________                                        Compound No. 23 of this invention                                                                   1        part                                           Bentonite             55       parts                                          Talc                  44       parts                                          ______________________________________                                    

The above components are mixed and pulverized homogeneously, then asmall amount of water is added and the whole is stirred, kneaded andgranulated by excluding granulator, then dried to prepare a granule.

If desired, the compound of this invention may be applied as a mixturewith other kinds of herbicides, various insecticides, sterilizers oradjuvants during preparation or before spraying.

Such other kinds of herbicides as mentioned above include compounds asdescribed in Farm Chemicals Handbook (1986).

The compounds of this invention can also be applied not only to theagricultural and horticultural fields such as farm fields, paddy fields,fruit gardens and the like, but to the non-agricultural fields such asathletic grounds, vacant lands, belts along railroads and others inorder to prevent and eliminate various weeds. The amounts of theherbicide to be applied, which may differ depending on the scenes to beapplied, the time of application, the application method, the kinds ofthe objective grasses and the crops harvested, may generally rangesuitably from about 0.005 to 10 kg per hectare in terms of the activeingredient.

The following test examples are set forth for illustrating specificallythe effectiveness of the compounds of this invention as herbicides.

TEST EXAMPLE 1 Herbicidal effect test by soil treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there wasplaced a sterilized deluvium soil, and seeds of (A) barnyardgrass(Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C)annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrumL.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress(Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I)wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton(Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown mixedly.After covering the seeds with soil to about 1.5 cm, herbicides weresprayed evenly on the soil surface respectively such that apredetermined proportion of the active ingredient may be applied.

In spraying, the wettable powder as shown in the foregoing exemplaryformulations was diluted with water and sprayed over the entire surfaceby means of a small sprayer. Four weeks after spraying, the herbicidaleffect on crops and each of the weeds were examined according to thejudgment criteria shown below. Provided that, in the following Table, amark "-" was shown in the column of activity when beet was omitted fromthe crops to be tested.

The results are shown in Table 16.

Some of the compounds of this invention show the selectivity on certaincrops.

    ______________________________________                                        Judgment criteria:                                                            ______________________________________                                        5 . . .  Growth control rates of more than 90%                                         (almost completely withered)                                         4 . . .  Growth control rates of 70 to 90%                                    3 . . .  Growth control rates of 40 to 70%                                    2 . . .  Growth control rates of 20 to 40%                                    1 . . .  Growth control rates of 5 to 20%                                     0 . . .  Growth control rates of less than 5%                                          (substantially no effect)                                            ______________________________________                                    

The above growth control rates are determined by measuring the top freshweights of the treated plants and those of the non-treated plants, andcalculated from the following formula: ##EQU1##

                                      TABLE 16                                    __________________________________________________________________________          Amount of ac-                                                                 tive ingredi-                                                           Compound                                                                            ent applied                                                             No.   kg/ha   (A)                                                                              (B)                                                                              (C)                                                                              (D)                                                                              (E)                                                                              (F)                                                                              (G)                                                                              (H)                                                                              (I)                                                                              (J)                                                                              (K)                                                                              (L)                            __________________________________________________________________________     3    0.32    5  4  5  4  4  5  5  5  5  5  0  --                              6    0.32    5  5  5  5  5  5  5  5  5  5  0  --                              9    0.16    5  5  5  5  5  5  5  5  5  5  0  --                                   0.32    5  5  5  5  5  5  5  5  5  5  0  --                             11    0.08    5  5  5  5  5  5  5  5  5  5  5  0                                    0.16    5  5  5  5  5  5  5  5  5  5  5  0                              13    0.16    5  5  5  5  5  5  5  5  5  5  5  0                              16    0.08    5  3  5  5  5  5  5  5  3  3  0  0                                    0.16    5  4  5  5  5  5  5  5  4  4  1  0                              19    0.04    4  3  5  5  5  5  5  5  5  5  5  --                                   0.08    5  4  5  5  5  5  5  5  5  5  5  --                                   0.16    5  5  5  5  5  5  5  5  5  5  5  --                             21    0.04    4  4  4  4  5  5  5  4  0  4  0  --                                   0.08    5  5  5  5  5  5  5  5  1  5  0  --                                   0.16    5  5  5  5  5  5  5  5  2  5  1  --                             24    0.02    5  4  5  5  5  5  5  5  5  5  0  --                                   0.04    5  5  5  5  5  5  5  5  5  5  0  --                                   0.08    5  5  5  5  5  5  5  5  5  5  0  --                             __________________________________________________________________________     (A) barnyardgrass (Echinochloa crusgalli),                                    (B) large crabgrass (Digitaria adscendens),                                   (C) annual sedge (Cyperus microiria),                                         (D) black nightshade (Solanum nigrum L.),                                     (E) hairly galinosoga (Galinosoga ciliata),                                   (F) yellows cress (Rorippa atrovirens),                                       (G) rice (Oryza sativa),                                                      (H) corn (Zea mays),                                                           (I) wheat (Triticum vulgare),                                                (J) soybean (Glysine max),                                                    (K) cotton (Gossypium spp),                                                   (L) sugar beet (Beta vulgaris).                                          

TEST EXAMPLE 2 Herbicidal effect test by foliage treatment

In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there wasplaced a sterilized deluvium soil, and seeds of (A) barnyardgrass(Echinochloa crusgalli), (B) large crabgrass (Digitaria adscendens), (C)annual sedge (Cyperus microiria), (D) black nightshade (Solanum nigrumL.), (E) hairly galinosoga (Galinosoga ciliata), (F) yellows cress(Rorippa atrovirens), (G) rice (Oryza sativa), (H) corn (Zea mays), (I)wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton(Gossypium spp) and (L) sugar beet (Beta vulgaris) were sown in spots.After covering the seeds with soil to about 1.5 cm, herbicides weresprayed evenly on the soil surface such that a predetermined proportionof the active ingredient may be applied.

In spraying, the wettable powder as shown in the foregoing exemplaryformulations was diluted with water and sprayed over the entire surfaceof the foliage portions of each crop and weed by means of a smallsprayer. Four weeks after spraying, the herbicidal effect on crops etc.and each of the weeds were examined according to the judgment criteriashown in Test Example 1.

The results are shown in Table 17.

                                      TABLE 17                                    __________________________________________________________________________          Amount of ac-                                                                 tive ingredi-                                                           Compound                                                                            ent applied                                                             No.   kg/ha   (A)                                                                              (B)                                                                              (C)                                                                              (D)                                                                              (E)                                                                              (F)                                                                              (G)                                                                              (H)                                                                              (I)                                                                              (J)                                                                              (K)                                                                              (L)                            __________________________________________________________________________     3    0.08    5  2  5  5  5  5  5  5  5  5  0  5                                    0.16    5  3  5  5  5  5  5  5  5  5  1  5                               5    0.32    5  5  5  5  5  5  5  5  5  5  5  --                              6    0.04    5  1  4  5  5  5  5  5  0  5  5  5                                    0.08    5  2  5  5  5  5  5  5  1  5  5  5                                    0.16    5  3  5  5  5  5  5  5  2  5  5  5                               8    0.08    4  1  5  5  5  5  5  4  0  5  4  5                                    0.16    5  2  5  5  5  5  5  5  0  5  5  5                               9    0.04    5  3  4  5  5  5  5  5  4  5  5  5                                    0.08    5  4  5  5  5  5  5  5  5  5  5  5                                    0.16    5  5  5  5  5  5  5  5  5  5  5  5                              11    0.04    5  4  5  5  5  5  5  5  5  5  5  0                                    0.08    5  5  5  5  5  5  5  5  5  5  5  0                                    0.16    5  5  5  5  5  5  5  5  5  5  5  0                              13    0.16    5  5  5  5  5  5  5  5  5  5  5  0                              16    0.08    5  4  5  5  5  5  5  5  5  5  5  0                                    0.16    5  5  5  5  5  5  5  5  5  5  5  0                              19    0.04    5  4  5  5  5  5  5  5  5  5  5  5                                    0.08    5  5  5  5  5  5  5  5  5  5  5  5                                    0.16    5  5  5  5  5  5  5  5  5  5  5  5                              21    0.02    3  2  5  5  5  5  5  5  4  5  4  5                                    0.04    4  3  5  5  5  5  5  5  5  5  5  5                                    0.08    5  4  5  5  5  5  5  5  5  5  5  5                              24    0.01    5  4  5  5  5  5  5  5  4  5  4  5                                    0.02    5  5  5  5  5  5  5  5  5  5  5  5                                    0.04    5  5  5  5  5  5  5  5  5  5  5  5                              __________________________________________________________________________     (A) barnyardgrass (Echinochloa crusgalli),                                    (B) large crabgrass (Digitaria adscendens),                                   (C) annual sedge (Cyperus microiria),                                         (D) black nightshade (Solanum nigrum L.),                                     (E) hairly galinosoga (Galinosoga ciliata),                                   (F) yellows cress (Rorippa atrovirens),                                       (G) rice (Oryza sativa),                                                      (H) corn (Zea mays),                                                          (I) wheat (Triticum vulgare),                                                 (J) soybean (Glysine max),                                                    (K) cotton (Gossypium spp),                                                   (L) sugar beet (Beta vulgaris).                                          

We claim:
 1. An imidazolesulfonamide derivative represented by theformula (I): ##STR38## wherein Q represents a group of: ##STR39##wherein R¹, R² and R³ each independently represent a hydrogen atom, ahalogen atom, a nitro group, a lower alkyl group, a halogenated loweralkyl group, a cyano group, a group of COOR¹⁰, a group of S(O)_(n) R¹¹,a group of NR¹² R¹³, a lower alkoxy group, a group of SO₂ NR⁸ R⁹, agroup of SO₂ OR¹¹ or a phenyl group which may be substituted by ahalogen atom, a nitro group, a group of COOR¹⁰, a lower alkoxy group ora lower alkyl group;R⁴ and R⁵ each independently represent a hydrogenatom, a halogen atom, a lower alkyl group, a halogenated lower alkylgroup, a nitro group, a cyano group, a group of COOR¹⁰, a group ofS(O)_(n) R¹¹, a lower alkoxy group or a phenyl group which may besubstituted by a halogen atom, a group of COOR¹⁰, a nitro group, a loweralkoxy group or a lower alkyl group; R⁶ and R⁷ each independentlyrepresent a hydrogen atom, a halogen atom, a lower alkyl group, a loweralkoxy group, a nitro group or a group of COOR¹⁰ ; R⁸ and R⁹ eachindependently represent a hydrogen atom, a lower alkyl group or a phenylgroup; W¹ represents an oxygen atom, a sulfur atom or a group of N--R¹⁰; R¹⁰ represents a hydrogen atom or a lower alkyl group; R¹¹ representsa lower alkyl group and n represents an integer of 0, 1 or 2; and R¹²and R¹³ each independently represent a hydrogen atom or a lower alkylgroup; m represents an integer of 0, 1 or 2; R represents a hydrogenatom or a lower alkyl group; B and D each independently represent ahydrogen atom, a halogen atom, a nitro group, a lower alkyl group, alower aralkyl group, a lower alkoxy group, a halogenated lower alkylgroup, a halogenated lower alkenyl group, a lower alkoxyalkyl group, analkylcarbonyl group, a group of COOR¹⁴, a group of CONR¹⁵ R¹⁶, a groupof S(O)_(n) R¹⁷, a cyano group, a group of NR¹⁸ R¹⁹, a group of SO₂ NR²⁰R²¹, a group of OH, a benzoyl group which may be substituted by ahalogen atom or a lower alkyl group or a phenyl group which maysubstituted by is selected from a halogen atom, a nitro group, a groupof COOR¹⁰, a lower alkoxy group or a lower alkyl group; R¹⁴ represents ahydrogen atom, a lower alkyl group which may be substituted by a groupof OR¹⁰, a halogen atom, a halogenated lower alkoxy group, a cyanogroup, a phenoxy group, a lower alkoxycarbonyl group, a group of NR¹⁰R¹¹, a lower cycloalkyl group, a lower alkylthio group or a loweralkylcarbonyl group, a lower alkenyl group, a halogenated lower alkenylgroup, a lower alkynyl group, a halogenated lower alkynyl group, a lowercycloalkyl group or a benzyl group; R¹⁵ represents a hydrogen atom, alower alkyl group or a phenyl group; and R¹⁶ represents a hydrogen atom,a lower alkyl group or a lower alkoxy group; R¹⁷ represents a loweralkyl group, a lower alkoxy group, a phenyl group, a halogenated alkylgroup, a lower alkenyloxy group or a lower alkynyloxy group; and nrepresents an integer of 0, 1 or 2; R¹⁸ and R¹⁹ each independentlyrepresent a hydrogen atom, a lower alkyl group, a lower alkylcarbonylgroup or a lower alkylsulfonyl group; R²⁰ and R²¹ each independentlyrepresent a hydrogen atom, a lower alkyl group, a lower alkenyl group ora lower alkynyl group; T represents a group of ##STR40## E represents ahydrogen atom, a lower alkyl group, a lower alkenyl group, a loweralkynyl group or a lower alkoxy group; G represents a group of;##STR41## wherein X and Y each independently represent a hydrogen atom,a halogen atom, a lower alkyl group, a lower alkoxy group, a loweralkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxygroup, a group of NR²⁴ R²⁵, a group of OCH(R¹⁰)--COOR¹⁰, a group ofCOOR¹⁰, a cyclopropyl group, a group of CH(OR²⁶)₂, a lower alkylthiogroup or a halogenated lower alkylthio group;R²⁴ and R²⁵ eachindependently represent a hydrogen atom, a lower alkyl group or a loweralkoxy group; R²⁶ represents a lower alkyl group; X¹ and Y¹ eachindependently represent a hydrogen atom, a halogen atom, a lower alkylgroup, a halogenated alkyl group or a lower alkoxy group; Z represents agroup of C--R²⁷ ; H²⁷ represents a hydrogen atom, a lower alkyl group, ahalogenated lower alkyl group, a halogen atom, a lower alkoxy group or a5-membered ring structure containing an oxygen atom together with Y orY¹ ; W represents an oxygen atom, a sulfur atom or a group of N--R²⁸where R²⁸ represents a hydrogen atom or a lower alkoxy group; W²represents an oxygen atom or a sulfur atom; R²² represents a lower alkylgroup; Az represents a halogen atom, a nitro group, or an imidazolylgroup, an imidazolynyl group, a pyrazolyl group, a triazolyl group or abenzimidazolyl group each of which may be mono-, di- or tri-substitutedby a lower alkyl group; J represents a lower alkyl group or a group of;##STR42## wherein Q, R, m, B and D have the same meanings as definedabove; R²³ represents a hydrogen atom, a lower alkyl group or a loweralkoxy group.
 2. The compound of claim 1, which is represented by theformula: ##STR43## wherein R₁ represents a hydrogen atom, a methyl groupor a halogen atom; R represents a methyl group or an ethyl group; Q isselected from the group of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50,Q54, Q61, Q68, Q88, Q127, Q138, Q142, Q188, Q189, Q201, Q202, Q204,Q205, Q209, Q222, Q225, Q229, Q230, Q246 and Q250 as shown below:##STR44## X and Y are each independently a halogen atom, a methyl group,a methoxy group; and Z is --CH═.
 3. The compound of claim 2, which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-thiazolyl)imidazole-5-sulfonamide.4. The compound of claim 2, which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-thiazolyl)imidazole-5-sulfonamide.5. The compound of claim 2, which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide.6. The compound of claim 2, which isN-[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyridyl)imidazole-5-sulfonamide.7. The compound of claim 2, which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-methoxycarbonyl-1-(2-pyrimidyl)imidazole-5-sulfonamide.8. The compound of claim 1, which is represented by the formula:##STR45## wherein R₁ represents a hydrogen atom or a methyl group; Rrepresents a methyl group or an ethyl group; Q is selected from thegroup of Q5, Q6, Q7, Q9, Q15, Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68,Q88, Q127, Q138, Q142, Q188, Q189, Q201, Q202, Q204, Q205, Q209, Q222,Q225, Q229, Q230, Q246 and Q250 as shown below: ##STR46## X and Y areeach independently a halogen atom, a methyl group, a methoxy group; andZ is --CH═.
 9. The compound of claim 1, which is represented by theformula: ##STR47## wherein R₁ represents a hydrogen atom, a methylgroup, a halogen atom or a nitro group; R represents a methyl group oran ethyl group; Q is selected from the group of Q5, Q6, Q7, Q9, Q15,Q21, Q26, Q29, Q32, Q50, Q54, Q61, Q68, Q88, Q127, Q138, Q142, Q188,Q189, Q201, Q202, Q204, Q205, Q209, Q222, Q225, Q229, Q230, Q246 andQ250 as shown below: ##STR48## X and Y are each independently a halogenatom, a methyl group, a methoxy group; and Z is --CH═.
 10. The compoundof claim 2, which isN-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyridyl)imidazole-5-sulfonamide.11. The compound of claim 2, which is the compound where R is an ethylgroup, R₁ is a hydrogen atom and Q is Q204.
 12. The compound of claim11, wherein X and Y are each independently selected from methyl andmethoxy.
 13. The compound of claim 12, wherein X and Y are each methoxy.14. The compound of claim 2, which is the compound where R is an ethylgroup, R₁ is a hydrogen atom and Q is Q222.
 15. The compound of claim14, wherein X and Y are each independently selected from methyl andmethoxy.
 16. The compound of claim 15, wherein X and Y are each methoxy.17. The compound of claim 1, wherein G is ##STR49##
 18. A method forinhibiting growth of undesirable plants by using the compoundrepresented by the formula (I): ##STR50## wherein Q represents a groupof: ##STR51## wherein R¹, R² and R³ each independently represent ahydrogen atom, a halogen atom, a nitro group, a lower alkyl group, ahalogenated lower alkyl group,a cyano group, a group of COOR¹⁰, a groupof S(O)_(n) R¹¹, a group of NR¹² R¹³, a lower alkoxy group, a group ofSO₂ NR⁸ R⁹, a group of SO₂ OR¹¹ or a phenyl group which may besubstituted by a halogen atom, a nitro group, a group of COOR¹⁰, a loweralkoxy group or a lower alkyl group; R⁴ and R⁵ each independentlyrepresent a hydrogen atom, a halogen atom, a lower alkyl group, ahalogenated lower alkyl group, a nitro group, a cyano group, a group ofCOOR¹⁰, a group of S(O)_(n) R¹¹, a lower alkoxy group or a phenyl groupwhich may be substituted by a halogen atom, a group of COOR¹⁰, a nitrogroup, a lower alkoxy group or a lower alkyl group; R⁶ and R⁷ eachindependently represent a hydrogen atom, a halogen atom, a lower alkylgroup, a lower alkoxy group, a nitro group or a group of COOR¹⁰ ; R⁸ andR⁹ each independently represent a hydrogen atom, a lower alkyl group ora phenyl group; W¹ represents an oxygen atom, a sulfur atom or a groupof N--R¹⁰ ; R¹⁰ represents a hydrogen atom or a lower alkyl group; R¹¹represents a lower alkyl group and n represents an integer of 0, 1 or 2;and R¹² and R¹³ each independently represent a hydrogen atom or a loweralkyl group;m represents an integer of 0, 1 or 2; R represents ahydrogen atom or a lower alkyl group; B and D each independentlyrepresent a hydrogen atom, a halogen atom, a nitro group, a lower alkylgroup, a lower aralkyl group, a lower alkoxy group, a halogenated loweralkyl group, a halogenated lower alkenyl group, a lower alkoxyalkylgroup, an alkylcarbonyl group, a group of COOR¹⁴, a group of CONR¹⁵ R¹⁶,a group of S(O)_(n) R¹⁷, a cyano group, a group of NR¹⁸ R¹⁹, a group ofSO₂ NR²⁰ R²¹, a group of OH, a benzoyl group which may be substituted bya halogen atom or a lower alkyl group or a phenyl group which maysubstituted by is selected from a halogen atom, a nitro group, a groupof COOR¹⁰, a lower alkoxy group or a lower alkyl group; R¹⁴ represents ahydrogen atom, a lower alkyl group which may be substituted by a groupof OR¹⁰, a halogen atom, a halogenated lower alkoxy group, a cyanogroup, a phenoxy group, a lower alkoxycarbonyl group, a group of NR¹⁰R¹¹, a lower cycloalkyl group, a lower alkylthio group or a loweralkylcarbonyl group, a lower alkenyl group, a halogenated lower alkenylgroup, a lower alkynyl group, a halogenated lower alkynyl group, a lowercycloalkyl group or a benzyl group; R¹⁵ represents a hydrogen atom, alower alkyl group or a phenyl group; and R¹⁶ represents a hydrogen atom,a lower alkyl group or a lower alkoxy group; R¹⁷ represents a loweralkyl group, a lower alkoxy group, a phenyl group, a halogenated alkylgroup, a lower alkenyloxy group or a lower alkynyloxy group; and nrepresents an integer of 0, 1 or 2; R¹⁸ and R¹⁹ each independentlyrepresent a hydrogen atom, a lower alkyl group, a lower alkylcarbonylgroup or a lower alkylsulfonyl group; R²⁰ and R²¹ each independentlyrepresent a hydrogen atom, a lower alkyl group, a lower alkenyl group ora lower alkynyl group; T represents a group of ##STR52## E represents ahydrogen atom, a lower alkyl group, a lower alkenyl group, a loweralkynyl group or a lower alkoxy group; G represents a group of:##STR53## wherein X and Y each independently represent a hydrogen atom,a halogen atom, a lower alkyl group, a lower alkoxy group, a loweralkoxyalkyl group, a halogenated alkyl group, a halogenated lower alkoxygroup, a group of NR²⁴ R²⁵, a group of OCH(R¹⁰)--COOR¹⁰, a group ofCOOR¹⁰, a cyclopropyl group, a group of CH(OR²⁶)₂, a lower alkylthiogroup or a halogenated lower alkylthio group;R²⁴ and R²⁵ eachindependently represent a hydrogen atom, a lower alkyl group or a loweralkoxy group; R²⁶ represents a lower alkyl group; X¹ and Y¹ eachindependently represent a hydrogen atom, a halogen atom, a lower alkylgroup; a halogenated alkyl group or a lower alkoxy group; Z represents agroup of C--R²⁷ ; R²⁷ represents a hydrogen atom, a lower alkyl group, ahalogenated lower alkyl group, a halogen atom, a lower alkoxy group or a5-membered ring structure containing an oxygen atom together with Y orY¹ ; W represents an oxygen atom, a sulfur atom or a group of N--R²⁸where R²⁸ represents a hydrogen atom or a lower alkoxy group; W²represents an oxygen atom or a sulfur atom; R²² represents a lower alkylgroup; Az represents a halogen atom, a nitro group, or an imidazolylgroup, an imidazolynyl group, a pyrazolyl group, a triazolyl group or abenzimidazolyl group each of which may be mono-, di- or tri-substitutedby a lower alkyl group; J represents a lower alkyl group or a group of;##STR54## wherein Q, R, m, B and D have the same meanings as definedabove; R²³ represents a hydrogen atom, a lower alkyl group or a loweralkoxy group.
 19. The method of claim 18, wherein G is ##STR55##
 20. Aherbicide which comprises a herbicidal carrier and as an effectiveingredient, a compound represented by the formula (I): ##STR56## whereinQ represents a group of; ##STR57## wherein R¹, R² and R³ eachindependently represent a hydrogen atom, a halogen atom, a nitro group,a lower alkyl group, a halogenated lower alkyl group, a cyano group, agroup of COOR¹⁰, a group of S(O)_(n) R¹¹, a group of NR¹² R¹³, a loweralkoxy group, a group of SO₂ NR⁸ R⁹, a group of SO₂ OR¹¹ or a phenylgroup which may be substituted by a halogen atom, a nitro group, a groupof COOR¹⁰, a lower alkoxy group or a lower alkyl group;R⁴ and R⁵ eachindependently represent a hydrogen atom, a halogen atom, a lower alkylgroup, a halogenated lower alkyl group, a nitro group, a cyano group, agroup of COOR¹⁰, a group of S(O)_(n) R¹¹, a lower alkoxy group or aphenyl group which may be substituted by a halogen atom, a group ofCOOR¹⁰, a nitro group, a lower alkoxy group or a lower alkyl group; R⁶and R⁷ each independently represent a hydrogen atom, a halogen atom, alower alkyl group, a lower alkoxy group, a nitro group or a group ofCOOR¹⁰ ; R⁸ and R⁹ each independently represent a hydrogen atom, a loweralkyl group or a phenyl group; W¹ represents an oxygen atom, a sulfuratom or a group of N--R¹⁰ ; R¹⁰ represents a hydrogen atom or a loweralkyl group; R¹¹ represents a lower alkyl group and n represents aninteger of 0, 1 or 2; and R¹² and R¹³ each independently represent ahydrogen atom or a lower alkyl group; m represents an integer of 0, 1 or2; R represents a hydrogen atom or a lower alkyl group; B and D eachindependently represent a hydrogen atom, a halogen atom, a nitro group,a lower alkyl group, a lower aralkyl group, a lower alkoxy group, ahalogenated lower alkyl group, a halogenated lower alkenyl group, alower alkoxyalkyl group, an alkylcarbonyl group, a group of COOR¹⁴, agroup of CONR¹⁵ R¹⁶, a group of S(O)_(n) R¹⁷, a cyano group, a group ofNR¹⁸ R¹⁹, a group of SO₂ NR²⁰ R²¹, a group of OH, a benzoyl group whichmay be substituted by a halogen atom or a lower alkyl group or a phenylgroup which may substituted by is selected from a halogen atom, a nitrogroup, a group of COOR¹⁰, a lower alkoxy group or a lower alkyl group;R¹⁴ represents a hydrogen atom, a lower alkyl group which may besubstituted by a group of OR¹⁰, a halogen atom, a halogenated loweralkoxy group, a cyano group, a phenoxy group, a lower alkoxycarbonylgroup, a group of NR¹⁰ R¹¹, a lower cycloalkyl group, a lower alkylthiogroup or a lower alkylcarbonyl group, a lower alkenyl group, ahalogenated lower alkenyl group, a lower alkynyl group, a halogenatedlower alkynyl group, a lower cycloalkyl group or a benzyl group; R¹⁵represents a hydrogen atom, a lower alkyl group or a phenyl group; andR¹⁶ represents a hydrogen atom, a lower alkyl group or a lower alkoxygroup; R¹⁷ represents a lower alkyl group, a lower alkoxy group, aphenyl group, a halogenated alkyl group, a lower alkenyloxy group or alower alkynyloxy group; and n represents an integer of 0, 1 or 2; R¹⁸and R¹⁹ each independently represent a hydrogen atom, a lower alkylgroup, a lower alkylcarbonyl group or a lower alkylsulfonyl group; R²⁰and R²¹ each independently represent a hydrogen atom, a lower alkylgroup, a lower alkenyl group or a lower alkynyl group; T represents agroup of ##STR58## E represents a hydrogen atom, a lower alkyl group, alower alkenyl group, a lower alkynyl group or a lower alkoxy group; Grepresents a group of; ##STR59## wherein X and Y each independentlyrepresent a hydrogen atom, a halogen atom, a lower alkyl group, a loweralkoxy group, a lower alkoxyalkyl group, a halogenated alkyl group, ahalogenated lower alkoxy group, a group of NR²⁴ R²⁵, a group ofOCH(R¹⁰)--COOR¹⁰, a group of COOR¹⁰, a cyclopropyl group, a group ofCH(OR²⁶)₂, a lower alkylthio group or a halogenated lower alkylthiogroup;R²⁴ and R²⁵ each independently represent a hydrogen atom, a loweralkyl group or a lower alkoxy group; R²⁶ represents a lower alkyl group;X¹ and Y¹ each independently represent a hydrogen atom, a halogen atom,a lower alkyl group, a halogenated alkyl group or a lower alkoxy group;Z represents a group of C--R²⁷ ; R²⁷ represents a hydrogen atom, a loweralkyl group, a halogenated lower alkyl group, a halogen atom, a loweralkoxy group or a 5-membered ring structure containing an oxygen atomtogether with Y or Y¹ ; W represents an oxygen atom, a sulfur atom or agroup of N--R²⁸ where R²⁸ represents a hydrogen atom or a lower alkoxygroup; W² represents an oxygen atom or a sulfur atom;R²² represents alower alkyl group; Az represents a halogen atom, a nitro group, or animidazolyl group, an imidazolynyl group, a pyrazolyl group, a triazolylgroup or a benzimidazolyl group each of which may be mono-, di- ortri-substituted by a lower alkyl group; J represents a lower alkyl groupor a group of; ##STR60## wherein Q, R, m, B and D have the same meaningsas defined above; R²³ represents a hydrogen atom, a lower alkyl group ora lower alkoxy group.
 21. The herbicide of claim 20, wherein G is##STR61##